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Assembly of allosteric macromolecular switches: lessons from PKA

Nature reviews. Molecular cell biology, 2012-10, Vol.13 (10), p.646-658

2012

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Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers

Cell, 2013-08, Vol.154 (5), p.1036-1046

2013

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Dynamic architecture of a protein kinase

Proceedings of the National Academy of Sciences - PNAS, 2014-10, Vol.111 (43), p.E4623-E4631

2014

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Deciphering the structural basis of eukaryotic protein kinase regulation

PLoS biology, 2013-10, Vol.11 (10), p.e1001680

2013

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Defining the conserved internal architecture of a protein kinase

Biochimica et biophysica acta, 2010-03, Vol.1804 (3), p.440-444

2010

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Evolution of the eukaryotic protein kinases as dynamic molecular switches

Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2012-09, Vol.367 (1602), p.2517-2528

2012

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The “violin model”: Looking at community networks for dynamic allostery

The Journal of Chemical Physics, 2023-02, Vol.158 (8), p.081001-081001

2023

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helix scaffold for the assembly of active protein kinases

Proceedings of the National Academy of Sciences - PNAS, 2008-09, Vol.105 (38), p.14377-14382

2008

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Dynamic allostery-based molecular workings of kinase: peptide complexes

Proceedings of the National Academy of Sciences - PNAS, 2019-07, Vol.116 (30), p.15052-15061

2019

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Surface Comparison of Active and Inactive Protein Kinases Identifies a Conserved Activation Mechanism

Proceedings of the National Academy of Sciences - PNAS, 2006-11, Vol.103 (47), p.17783-17788

2006

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A dynamic hydrophobic core orchestrates allostery in protein kinases

Science advances, 2017-04, Vol.3 (4), p.e1600663-e1600663

2017

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Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII

Cell reports (Cambridge), 2015-08, Vol.12 (8), p.1252-1260

2015

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Dynamics-Driven Allostery in Protein Kinases

Trends in biochemical sciences (Amsterdam. Regular ed.), 2015-11, Vol.40 (11), p.628-647

2015

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Protein kinases: evolution of dynamic regulatory proteins

Trends in biochemical sciences (Amsterdam. Regular ed.), 2011-02, Vol.36 (2), p.65-77

2011

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Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF

Proceedings of the National Academy of Sciences - PNAS, 2011-04, Vol.108 (15), p.6067-6072

2011

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Self-organization, entropy and allostery

Biochemical Society transactions, 2018-06, Vol.46 (3), p.587-597

Kornev, Alexandr P

2018

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An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes

Structure (London), 2015-09, Vol.23 (9), p.1563-1572

2015

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Crystal Structure of cGMP-Dependent Protein Kinase Reveals Novel Site of Interchain Communication

Structure (London), 2011-09, Vol.19 (9), p.1317-1327

2011

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Localization and quaternary structure of the PKA RIβ holoenzyme

Proceedings of the National Academy of Sciences - PNAS, 2012-07, Vol.109 (31), p.12443-12448

2012

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PKA RIα Homodimer Structure Reveals an Intermolecular Interface with Implications for Cooperative cAMP Binding and Carney Complex Disease

Structure (London), 2014-01, Vol.22 (1), p.59-69

2014

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Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase

Proceedings of the National Academy of Sciences - PNAS, 2012-05, Vol.109 (20), p.E1221-E1229

2012

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Calculation of centralities in protein kinase A

Proceedings of the National Academy of Sciences - PNAS, 2022-11, Vol.119 (47), p.e2215420119-e2215420119

2022

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Tuning the “violin” of protein kinases: The role of dynamics‐based allostery

IUBMB life, 2019-06, Vol.71 (6), p.685-696

2019

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PKA: Lessons learned after twenty years

Biochimica et biophysica acta, 2013-07, Vol.1834 (7), p.1271-1278

2013

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Kinases and Pseudokinases: Lessons from RAF

Molecular and cellular biology, 2014-05, Vol.34 (9), p.1538-1546

2014

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Assembly of allosteric macromolecular switches: lessons from PKA

Allosteric Activation of Functionally Asymmetric RAF Kinase Dimers

Dynamic architecture of a protein kinase

Deciphering the structural basis of eukaryotic protein kinase regulation

Defining the conserved internal architecture of a protein kinase

Evolution of the eukaryotic protein kinases as dynamic molecular switches

The “violin model”: Looking at community networks for dynamic allostery

helix scaffold for the assembly of active protein kinases

Dynamic allostery-based molecular workings of kinase: peptide complexes

Surface Comparison of Active and Inactive Protein Kinases Identifies a Conserved Activation Mechanism

A dynamic hydrophobic core orchestrates allostery in protein kinases

Intramolecular C2 Domain-Mediated Autoinhibition of Protein Kinase C βII

Dynamics-Driven Allostery in Protein Kinases

Protein kinases: evolution of dynamic regulatory proteins

Mutation that blocks ATP binding creates a pseudokinase stabilizing the scaffolding function of kinase suppressor of Ras, CRAF and BRAF

Self-organization, entropy and allostery

An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes

Crystal Structure of cGMP-Dependent Protein Kinase Reveals Novel Site of Interchain Communication

Localization and quaternary structure of the PKA RIβ holoenzyme

PKA RIα Homodimer Structure Reveals an Intermolecular Interface with Implications for Cooperative cAMP Binding and Carney Complex Disease

Cotranslational cis-phosphorylation of the COOH-terminal tail is a key priming step in the maturation of cAMP-dependent protein kinase

Calculation of centralities in protein kinase A

Tuning the “violin” of protein kinases: The role of dynamics‐based allostery

PKA: Lessons learned after twenty years

Kinases and Pseudokinases: Lessons from RAF

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