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inhibitors of apoptosis (IAPs) as cancer targets

Apoptosis (London), 2007-09, Vol.12 (9), p.1543-1568

2007

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Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

Nature communications, 2017-02, Vol.8 (1), p.1-15, Article 14278

2017

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Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2

Immunity (Cambridge, Mass.), 2009-06, Vol.30 (6), p.789-801

2009

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Searching for IRES

RNA (Cambridge), 2006-10, Vol.12 (10), p.1755-1785

2006

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Smac mimetics and innate immune stimuli synergize to promote tumor death

Nature biotechnology, 2014-02, Vol.32 (2), p.182-190

2014

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LCL161 enhances expansion and survival of engineered anti-tumor T cells but is restricted by death signaling

Frontiers in immunology, 2023-04, Vol.14, p.1179827-1179827

2023

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XIAP: apoptotic brake and promising therapeutic target

Apoptosis (London), 2001-08, Vol.6 (4), p.253-261

2001

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Degradation of Survivin by the X-linked Inhibitor of Apoptosis (XIAP)-XAF1 Complex

The Journal of biological chemistry, 2007-09, Vol.282 (36), p.26202-26209

2007

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Inhibitor of Apoptosis Protein cIAP2 Is Essential for Lipopolysaccharide-Induced Macrophage Survival

Molecular and Cellular Biology, 2006-01, Vol.26 (2), p.699-708

2006

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Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy

Skeletal muscle, 2019-05, Vol.9 (1), p.13-13, Article 13

2019

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Down-regulation of c-FLIP Enhances Death of Cancer Cells by Smac Mimetic Compound

Cancer research (Chicago, Ill.), 2009-10, Vol.69 (19), p.7729-7738

2009

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Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death

Oncogene, 2000-08, Vol.19 (36), p.4174-4177

2000

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Identification of XAF1 as an antagonist of XIAP anti-Caspase activity

Nature cell biology, 2001-02, Vol.3 (2), p.128-133

2001

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Antisense Oligonucleotides Targeting XIAP Induce Apoptosis and Enhance Chemotherapeutic Activity against Human Lung Cancer Cells in Vitro and in Vivo

Clinical cancer research, 2003-07, Vol.9 (7), p.2826-2836

2003

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XIAP protection of photoreceptors in animal models of retinitis pigmentosa

PloS one, 2007-03, Vol.2 (3), p.e314-e314

2007

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The Internal Ribosome Entry Site-Mediated Translation of Antiapoptotic Protein XIAP Is Modulated by the Heterogeneous Nuclear Ribonucleoproteins C1 and C2

Molecular and Cellular Biology, 2003-01, Vol.23 (1), p.280-288

2003

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Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells

Molecular & cellular oncology, 2019-07, Vol.6 (4), p.1607456-1607456

2019

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A new internal-ribosome-entry-site motif potentiates XIAP- mediated cytoprotection

Nature cell biology, 1999-07, Vol.1 (3), p.190-192

1999

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Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

Nature (London), 1996-01, Vol.379 (6563), p.349-353

1996

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Expression and Genetic Analysis of XIAP-Associated Factor 1 (XAF1) in Cancer Cell Lines

Genomics (San Diego, Calif.), 2000-11, Vol.70 (1), p.113-122

2000

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Combination of IAP Antagonists and TNF-α-Armed Oncolytic Viruses Induce Tumor Vascular Shutdown and Tumor Regression

Molecular therapy. Oncolytics, 2018-09, Vol.10, p.28-39

2018

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Distinct Regulation of Internal Ribosome Entry Site-mediated Translation following Cellular Stress Is Mediated by Apoptotic Fragments of eIF4G Translation Initiation Factor Family Members eIF4GI and p97/DAP5/NAT1

The Journal of biological chemistry, 2003-02, Vol.278 (6), p.3572-3579

2003

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Modulation of immune signalling by inhibitors of apoptosis

Trends in immunology, 2012-11, Vol.33 (11), p.535-545

2012

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XIAP Overexpression in Human Islets Prevents Early Posttransplant Apoptosis and Reduces the Islet Mass Needed to Treat Diabetes

Diabetes (New York, N.Y.), 2005-09, Vol.54 (9), p.2541-2548

2005

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Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

Nature immunology, 2008-12, Vol.9 (12), p.1371-1378

2008

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inhibitors of apoptosis (IAPs) as cancer targets

Smac mimetics synergize with immune checkpoint inhibitors to promote tumour immunity against glioblastoma

Cellular Inhibitors of Apoptosis cIAP1 and cIAP2 Are Required for Innate Immunity Signaling by the Pattern Recognition Receptors NOD1 and NOD2

Searching for IRES

Smac mimetics and innate immune stimuli synergize to promote tumor death

LCL161 enhances expansion and survival of engineered anti-tumor T cells but is restricted by death signaling

XIAP: apoptotic brake and promising therapeutic target

Degradation of Survivin by the X-linked Inhibitor of Apoptosis (XIAP)-XAF1 Complex

Inhibitor of Apoptosis Protein cIAP2 Is Essential for Lipopolysaccharide-Induced Macrophage Survival

Targeted ablation of the cellular inhibitor of apoptosis 1 (cIAP1) attenuates denervation-induced skeletal muscle atrophy

Down-regulation of c-FLIP Enhances Death of Cancer Cells by Smac Mimetic Compound

Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death

Identification of XAF1 as an antagonist of XIAP anti-Caspase activity

Antisense Oligonucleotides Targeting XIAP Induce Apoptosis and Enhance Chemotherapeutic Activity against Human Lung Cancer Cells in Vitro and in Vivo

XIAP protection of photoreceptors in animal models of retinitis pigmentosa

The Internal Ribosome Entry Site-Mediated Translation of Antiapoptotic Protein XIAP Is Modulated by the Heterogeneous Nuclear Ribonucleoproteins C1 and C2

Sp3-cificity of TNF-α expression promotes the Smac mimetic-mediated killing of cancer cells

A new internal-ribosome-entry-site motif potentiates XIAP- mediated cytoprotection

Suppression of apoptosis in mammalian cells by NAIP and a related family of IAP genes

Expression and Genetic Analysis of XIAP-Associated Factor 1 (XAF1) in Cancer Cell Lines

Combination of IAP Antagonists and TNF-α-Armed Oncolytic Viruses Induce Tumor Vascular Shutdown and Tumor Regression

Distinct Regulation of Internal Ribosome Entry Site-mediated Translation following Cellular Stress Is Mediated by Apoptotic Fragments of eIF4G Translation Initiation Factor Family Members eIF4GI and p97/DAP5/NAT1

Modulation of immune signalling by inhibitors of apoptosis

XIAP Overexpression in Human Islets Prevents Early Posttransplant Apoptosis and Reduces the Islet Mass Needed to Treat Diabetes

Noncanonical NF-κB activation requires coordinated assembly of a regulatory complex of the adaptors cIAP1, cIAP2, TRAF2 and TRAF3 and the kinase NIK

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