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Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species

Psychopharmacologia, 2005-10, Vol.182 (1), p.132-143

2005

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Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice

Cancer research (Chicago, Ill.), 1998-11, Vol.58 (21), p.4947-4956

1998

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Systematic LC/MS metabolite identification in drug discovery

Analytical chemistry (Washington), 2001-08, Vol.73 (15), p.430A-439A

2001

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Chiral liquid chromatography-tandem mass spectrometric methods for stereoisomeric pharmaceutical determinations

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2005-06, Vol.820 (1), p.1-8

2005

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Direct simultaneous analysis of plasma samples for a drug discovery compound and its hydroxyl metabolite using mixed-function column liquid chromatography-tandem mass spectrometry

Analyst (London), 2001-12, Vol.126 (12), p.2139-2143

2001

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Microsample Determination of Lovastatin and its Hydroxy Acid Metabolite in Mouse and Rat Plasma by Liquid Chromatography/Ionspray Tandem Mass Spectrometry

Journal of mass spectrometry., 1997-04, Vol.32 (4), p.379-387

1997

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Quantitative screening and matrix effect studies of drug discovery compounds in monkey plasma using fast-gradient liquid chromatography/tandem mass spectrometry

Rapid communications in mass spectrometry, 2001-12, Vol.15 (24), p.2481-2487

2001

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Cassette-accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery

Rapid communications in mass spectrometry, 2001-01, Vol.15 (5), p.335-340

2001

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Pharmacokinetic screening for the selection of new drug discovery candidates is greatly enhanced through the use of liquid chromatography–atmospheric pressure ionization tandem mass spectrometry

Journal of Chromatography A, 1997-08, Vol.777 (1), p.61-66

1997

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Principles and applications of LC-MS in new drug discovery

Drug discovery today, 2005-10, Vol.10 (20), p.1357-1367

Korfmacher, Walter A

2005

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Effects of SCH 59228, an orally bioavailable farnesyl protein transferase inhibitor, on the growth of oncogene-transformed fibroblasts and a human colon carcinoma xenograft in nude mice

Cancer chemotherapy and pharmacology, 1999, Vol.43 (1), p.50-58

1999

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HPLC-API/MS/MS: a powerful tool for integrating drug metabolism into the drug discovery process

Drug discovery today, 1997-12, Vol.2 (12), p.532-537

1997

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Novel in vivo procedure for rapid pharmacokinetic screening of discovery compounds in rats

Drug Discovery Today, 1999-05, Vol.4 (5), p.232-237

1999

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Fungal transformations of antihistamines: metabolism of brompheniramine, chlorpheniramine, and pheniramine to N-oxide and N-demethylated metabolites by the fungus Cunninghamella elegans

Xenobiotica, 1995, Vol.25 (10), p.1081-1092

1995

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Utility of solution electrochemistry mass spectrometry for investigating the formation and detection of biologically important conjugates of acetaminophen

Journal of chromatography, 1989-07, Vol.474 (1), p.245-256

1989

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DNA adduct formation in target tissues of Sprague-Dawley rats, CD-1 mice and A/J mice following tumorigenic doses of 1-nitropyrene

Carcinogenesis (New York), 1990-10, Vol.11 (10), p.1705-1710

1990

Volltextzugriff (PDF)

High-performance liquid chromatography—thermospray mass spectrometry of ten sulfonamide antibiotics: Analysis in milk at the ppb level

Journal of Chromatography A, 1993-01, Vol.629 (2), p.267-276

1993

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Direct analysis of plasma samples for drug discovery compounds using mixed-function column liquid chromatography tandem mass spectrometry

Rapid communications in mass spectrometry, 2000-08, Vol.14 (15), p.1384-1390

2000

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Fungal transformations of antihistamines: metabolism of cyproheptadine hydrochloride by Cunninghamella elegans

Xenobiotica, 1997-03, Vol.27 (3), p.301-315

1997

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Resistance to photochemical decomposition of polycyclic aromatic hydrocarbons vapor-adsorbed on coal fly ash

Environmental science & technology, 1980-09, Vol.14 (9), p.1094-1099

1980

Volltextzugriff (PDF)

Plasma elimination and urinary excretion of methapyrilene in the rat

Drug metabolism and disposition, 1990-11, Vol.18 (6), p.1018

1990

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Microbial transformation of the antihistamine pyrilamine maleate. Formation of potential mammalian metabolites

Drug metabolism and disposition, 1987-01, Vol.15 (1), p.97

1987

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Application of HPLC-Thermospray Ionization Mass Spectrometry for the Analysis of Triprolidine and Its Metabolite Hydroxymethyltriprolidine in Biological Samples

Journal of analytical toxicology, 1989-05, Vol.13 (3), p.185-187

1989

Volltextzugriff (PDF)

Molecular determinants of the platelet aggregation inhibitory activity of carbamoylpiperidines

Journal of medicinal chemistry, 1992-08, Vol.35 (16), p.2952-2958

1992

Volltextzugriff (PDF)

Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometry

Journal of mass spectrometry., 2003-10, Vol.38 (10), p.1081-1092

2003

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Characterization of the nociceptin receptor (ORL-1) agonist, Ro64-6198, in tests of anxiety across multiple species

Antitumor activity of SCH 66336, an orally bioavailable tricyclic inhibitor of farnesyl protein transferase, in human tumor xenograft models and Wap-ras transgenic mice

Systematic LC/MS metabolite identification in drug discovery

Chiral liquid chromatography-tandem mass spectrometric methods for stereoisomeric pharmaceutical determinations

Direct simultaneous analysis of plasma samples for a drug discovery compound and its hydroxyl metabolite using mixed-function column liquid chromatography-tandem mass spectrometry

Microsample Determination of Lovastatin and its Hydroxy Acid Metabolite in Mouse and Rat Plasma by Liquid Chromatography/Ionspray Tandem Mass Spectrometry

Quantitative screening and matrix effect studies of drug discovery compounds in monkey plasma using fast-gradient liquid chromatography/tandem mass spectrometry

Cassette-accelerated rapid rat screen: a systematic procedure for the dosing and liquid chromatography/atmospheric pressure ionization tandem mass spectrometric analysis of new chemical entities as part of new drug discovery

Pharmacokinetic screening for the selection of new drug discovery candidates is greatly enhanced through the use of liquid chromatography–atmospheric pressure ionization tandem mass spectrometry

Principles and applications of LC-MS in new drug discovery

Effects of SCH 59228, an orally bioavailable farnesyl protein transferase inhibitor, on the growth of oncogene-transformed fibroblasts and a human colon carcinoma xenograft in nude mice

HPLC-API/MS/MS: a powerful tool for integrating drug metabolism into the drug discovery process

Novel in vivo procedure for rapid pharmacokinetic screening of discovery compounds in rats

Fungal transformations of antihistamines: metabolism of brompheniramine, chlorpheniramine, and pheniramine to N-oxide and N-demethylated metabolites by the fungus Cunninghamella elegans

Utility of solution electrochemistry mass spectrometry for investigating the formation and detection of biologically important conjugates of acetaminophen

DNA adduct formation in target tissues of Sprague-Dawley rats, CD-1 mice and A/J mice following tumorigenic doses of 1-nitropyrene

High-performance liquid chromatography—thermospray mass spectrometry of ten sulfonamide antibiotics: Analysis in milk at the ppb level

Direct analysis of plasma samples for drug discovery compounds using mixed-function column liquid chromatography tandem mass spectrometry

Fungal transformations of antihistamines: metabolism of cyproheptadine hydrochloride by Cunninghamella elegans

Resistance to photochemical decomposition of polycyclic aromatic hydrocarbons vapor-adsorbed on coal fly ash

Plasma elimination and urinary excretion of methapyrilene in the rat

Microbial transformation of the antihistamine pyrilamine maleate. Formation of potential mammalian metabolites

Application of HPLC-Thermospray Ionization Mass Spectrometry for the Analysis of Triprolidine and Its Metabolite Hydroxymethyltriprolidine in Biological Samples

Molecular determinants of the platelet aggregation inhibitory activity of carbamoylpiperidines

Direct analysis of drug candidates in tissue by matrix-assisted laser desorption/ionization mass spectrometry

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