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Medication effects on developmental sterol biosynthesis

Molecular psychiatry, 2022-01, Vol.27 (1), p.490-501

2022

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Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain

Journal of lipid research, 2022-08, Vol.63 (8), p.100249, Article 100249

2022

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Oxysterols from Free Radical Chain Oxidation of 7-Dehydrocholesterol: Product and Mechanistic Studies

Journal of the American Chemical Society, 2010-02, Vol.132 (7), p.2222-2232

2010

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Maternal cariprazine exposure inhibits embryonic and postnatal brain cholesterol biosynthesis

Molecular psychiatry, 2020-11, Vol.25 (11), p.2685-2694

2020

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Identification and characterization of prescription drugs that change levels of 7-dehydrocholesterol and desmosterol

Journal of lipid research, 2018-10, Vol.59 (10), p.1916-1926

2018

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Vulnerability of DHCR7+/− mutation carriers to aripiprazole and trazodone exposure

Journal of lipid research, 2017-11, Vol.58 (11), p.2139-2146

2017

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Maternal aripiprazole exposure interacts with 7-dehydrocholesterol reductase mutations and alters embryonic neurodevelopment

Molecular psychiatry, 2019-04, Vol.24 (4), p.491-500

2019

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Trazodone effects on developing brain

Translational psychiatry, 2021-02, Vol.11 (1), p.85-9, Article 85

2021

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Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome[S]

Journal of lipid research, 2010-11, Vol.51 (11), p.3259-3269

2010

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Chemical Inhibition of Sterol Biosynthesis

Biomolecules (Basel, Switzerland), 2024-04, Vol.14 (4), p.410

2024

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Enhancing 7-dehydrocholesterol suppresses brain ferroptosis and tissue injury after neonatal hypoxia–ischemia

Scientific reports, 2024-04, Vol.14 (1), p.7924-7924, Article 7924

2024

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The Effect of Small Molecules on Sterol Homeostasis: Measuring 7‑Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts

Journal of medicinal chemistry, 2016-02, Vol.59 (3), p.1102-1115

2016

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Dichlorophenyl piperazines, including a recently-approved atypical antipsychotic, are potent inhibitors of DHCR7, the last enzyme in cholesterol biosynthesis

Toxicology and applied pharmacology, 2018-06, Vol.349, p.21-28

2018

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Plasma Retinol Concentrations and Dietary Intakes of Mother-Infant Sets in Singleton versus Twin Pregnancy

Nutrients, 2023-05, Vol.15 (11), p.2553

2023

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A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome[S]

Journal of lipid research, 2014-02, Vol.55 (2), p.329-337

2014

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Engineering Neurotoxin-Functionalized Exosomes for Targeted Delivery to the Peripheral Nervous System

Pharmaceutics, 2024-01, Vol.16 (1), p.102

2024

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DHCEO accumulation is a critical mediator of pathophysiology in a Smith–Lemli–Opitz syndrome model

Neurobiology of disease, 2012-03, Vol.45 (3), p.923-929

2012

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Effects of Psychotropic Medication on Somatic Sterol Biosynthesis of Adult Mice

Biomolecules (Basel, Switzerland), 2022-10, Vol.12 (10), p.1535

2022

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Retinol and Pro-Vitamin A Carotenoid Nutritional Status during Pregnancy Is Associated with Newborn Hearing Screen Results

Nutrients, 2023-02, Vol.15 (4), p.800

2023

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Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells[S]

Journal of lipid research, 2013-04, Vol.54 (4), p.1135-1143

2013

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An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome[S]

Journal of lipid research, 2011-06, Vol.52 (6), p.1222-1233

2011

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An altered peripheral IL6 response in major depressive disorder

Neurobiology of disease, 2016-05, Vol.89, p.46-54

2016

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Chronic Aripiprazole and Trazodone Polypharmacy Effects on Systemic and Brain Cholesterol Biosynthesis

Biomolecules (Basel, Switzerland), 2023-08, Vol.13 (9), p.1321

2023

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CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression

Biomolecules (Basel, Switzerland), 2024-07, Vol.14 (8), p.914

2024

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Neonatal Hypoxic-Ischemic Brain Injury Alters Brain Acylcarnitine Levels in a Mouse Model

Metabolites, 2022-05, Vol.12 (5), p.467

2022

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Medication effects on developmental sterol biosynthesis

Individual and simultaneous treatment with antipsychotic aripiprazole and antidepressant trazodone inhibit sterol biosynthesis in the adult brain

Oxysterols from Free Radical Chain Oxidation of 7-Dehydrocholesterol: Product and Mechanistic Studies

Maternal cariprazine exposure inhibits embryonic and postnatal brain cholesterol biosynthesis

Identification and characterization of prescription drugs that change levels of 7-dehydrocholesterol and desmosterol

Vulnerability of DHCR7+/− mutation carriers to aripiprazole and trazodone exposure

Maternal aripiprazole exposure interacts with 7-dehydrocholesterol reductase mutations and alters embryonic neurodevelopment

Trazodone effects on developing brain

Biological activities of 7-dehydrocholesterol-derived oxysterols: implications for Smith-Lemli-Opitz syndrome[S]

Chemical Inhibition of Sterol Biosynthesis

Enhancing 7-dehydrocholesterol suppresses brain ferroptosis and tissue injury after neonatal hypoxia–ischemia

The Effect of Small Molecules on Sterol Homeostasis: Measuring 7‑Dehydrocholesterol in Dhcr7-Deficient Neuro2a Cells and Human Fibroblasts

Dichlorophenyl piperazines, including a recently-approved atypical antipsychotic, are potent inhibitors of DHCR7, the last enzyme in cholesterol biosynthesis

Plasma Retinol Concentrations and Dietary Intakes of Mother-Infant Sets in Singleton versus Twin Pregnancy

A highly sensitive method for analysis of 7-dehydrocholesterol for the study of Smith-Lemli-Opitz syndrome[S]

Engineering Neurotoxin-Functionalized Exosomes for Targeted Delivery to the Peripheral Nervous System

DHCEO accumulation is a critical mediator of pathophysiology in a Smith–Lemli–Opitz syndrome model

Effects of Psychotropic Medication on Somatic Sterol Biosynthesis of Adult Mice

Retinol and Pro-Vitamin A Carotenoid Nutritional Status during Pregnancy Is Associated with Newborn Hearing Screen Results

Metabolism of oxysterols derived from nonenzymatic oxidation of 7-dehydrocholesterol in cells[S]

An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome[S]

An altered peripheral IL6 response in major depressive disorder

Chronic Aripiprazole and Trazodone Polypharmacy Effects on Systemic and Brain Cholesterol Biosynthesis

CPT2 Deficiency Modeled in Zebrafish: Abnormal Neural Development, Electrical Activity, Behavior, and Schizophrenia-Related Gene Expression

Neonatal Hypoxic-Ischemic Brain Injury Alters Brain Acylcarnitine Levels in a Mouse Model

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