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Structure–Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions

Journal of medicinal chemistry, 2021-04, Vol.64 (7), p.3997-4019

2021

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In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier

Molecules (Basel, Switzerland), 2019-04, Vol.24 (7), p.1340

2019

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Effects of Novel Tacrine Derivatives on Mitochondrial Energy Metabolism and Monoamine Oxidase Activity—In Vitro Study

Molecular neurobiology, 2021-03, Vol.58 (3), p.1102-1113

2021

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Aromatic Esters of the Crinane Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Butyrylcholinesterase

Journal of natural products (Washington, D.C.), 2020-05, Vol.83 (5), p.1359-1367

2020

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Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids

Molecules (Basel, Switzerland), 2021-02, Vol.26 (5), p.1279

2021

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Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer's Disease

Molecules (Basel, Switzerland), 2019-04, Vol.24 (7), p.1307

2019

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Amaryllidaceae Alkaloids of Belladine-Type from Narcissus pseudonarcissus cv. Carlton as New Selective Inhibitors of Butyrylcholinesterase

Biomolecules (Basel, Switzerland), 2020-05, Vol.10 (5), p.800

2020

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Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease

Phytochemistry (Oxford), 2022-02, Vol.194, p.113017-113017, Article 113017

2022

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Dose Dependent Prophylactic Efficacy of 6-Chlorotacrine in Soman-Poisoned Mice

Acta medica Lékarskí fakulty Univerzity Karlovy v Hradci Králove, 2017-01, Vol.60 (4), p.140-145

2017

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Alkaloids of Dicranostigma franchetianum (Papaveraceae) and Berberine Derivatives as a New Class of Antimycobacterial Agents

Biomolecules (Basel, Switzerland), 2022-06, Vol.12 (6), p.844

2022

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Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease

European journal of medicinal chemistry, 2016-01, Vol.108, p.687-700

2016

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A Perspective on Multi-target Drugs for Alzheimer’s Disease

Trends in pharmacological sciences (Regular ed.), 2020-07, Vol.41 (7), p.434-445

2020

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Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer's disease: Synthesis, biological activity and in silico study

Bioorganic & medicinal chemistry letters, 2021-11, Vol.51, p.128374, Article 128374

2021

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Amiridine-piperazine hybrids as cholinesterase inhibitors and potential multitarget agents for Alzheimer's disease treatment

Bioorganic chemistry, 2021-07, Vol.112, p.104974, Article 104974

2021

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Alkaloids of Zephyranthes citrina (Amaryllidaceae) and their implication to Alzheimer's disease: Isolation, structural elucidation and biological activity

Bioorganic chemistry, 2021-02, Vol.107, p.104567, Article 104567

2021

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The Evaluation of Benefit of Newly Prepared Reversible Inhibitors of Acetylcholinesterase and Commonly Used Pyridostigmine as Pharmacological Pretreatment of Soman-Poisoned Mice

Acta medica Lékarskí fakulty Univerzity Karlovy v Hradci Králove, 2017-01, Vol.60 (1), p.37-43

2017

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Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties

RSC medicinal chemistry, 2021-07, Vol.12 (7), p.1154-1163

2021

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Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy

Pharmacology & therapeutics (Oxford), 2020-06, Vol.210, p.107518, Article 107518

2020

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Adamantane - A Lead Structure for Drugs in Clinical Practice

Current medicinal chemistry, 2016-08, Vol.23 (29), p.3245

2016

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Clinical Candidates Targeting the ATR-CHK1-WEE1 Axis in Cancer

Cancers, 2021-02, Vol.13 (4), p.795

2021

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Newly Developed Drugs for Alzheimer’s Disease in Relation to Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission

Neuroscience, 2018-02, Vol.370, p.191-206

2018

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Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies

International journal of molecular sciences, 2021-08, Vol.22 (15), p.8308

2021

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Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease

European journal of medicinal chemistry, 2017-02, Vol.127, p.250-262

2017

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Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease

Phytochemistry (Oxford), 2019-09, Vol.165, p.112055-112055, Article 112055

2019

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Structure–Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions

In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier

Effects of Novel Tacrine Derivatives on Mitochondrial Energy Metabolism and Monoamine Oxidase Activity—In Vitro Study

Aromatic Esters of the Crinane Amaryllidaceae Alkaloid Ambelline as Selective Inhibitors of Butyrylcholinesterase

Structure Elucidation and Cholinesterase Inhibition Activity of Two New Minor Amaryllidaceae Alkaloids

Derivatives of the β-Crinane Amaryllidaceae Alkaloid Haemanthamine as Multi-Target Directed Ligands for Alzheimer's Disease

Amaryllidaceae Alkaloids of Belladine-Type from Narcissus pseudonarcissus cv. Carlton as New Selective Inhibitors of Butyrylcholinesterase

Monoterpene indole alkaloids from Vinca minor L. (Apocynaceae): Identification of new structural scaffold for treatment of Alzheimer's disease

Dose Dependent Prophylactic Efficacy of 6-Chlorotacrine in Soman-Poisoned Mice

Alkaloids of Dicranostigma franchetianum (Papaveraceae) and Berberine Derivatives as a New Class of Antimycobacterial Agents

Cardanol-derived AChE inhibitors: Towards the development of dual binding derivatives for Alzheimer's disease

A Perspective on Multi-target Drugs for Alzheimer’s Disease

Derivatives of montanine-type alkaloids and their implication for the treatment of Alzheimer's disease: Synthesis, biological activity and in silico study

Amiridine-piperazine hybrids as cholinesterase inhibitors and potential multitarget agents for Alzheimer's disease treatment

Alkaloids of Zephyranthes citrina (Amaryllidaceae) and their implication to Alzheimer's disease: Isolation, structural elucidation and biological activity

The Evaluation of Benefit of Newly Prepared Reversible Inhibitors of Acetylcholinesterase and Commonly Used Pyridostigmine as Pharmacological Pretreatment of Soman-Poisoned Mice

Discovery of sustainable drugs for Alzheimer's disease: cardanol-derived cholinesterase inhibitors with antioxidant and anti-amyloid properties

Discovery of ATR kinase inhibitor berzosertib (VX-970, M6620): Clinical candidate for cancer therapy

Development of 3,5-Dinitrophenyl-Containing 1,2,4-Triazoles and Their Trifluoromethyl Analogues as Highly Efficient Antitubercular Agents Inhibiting Decaprenylphosphoryl-β‑d‑ribofuranose 2′-Oxidase

Adamantane - A Lead Structure for Drugs in Clinical Practice

Clinical Candidates Targeting the ATR-CHK1-WEE1 Axis in Cancer

Newly Developed Drugs for Alzheimer’s Disease in Relation to Energy Metabolism, Cholinergic and Monoaminergic Neurotransmission

Amaryllidaceae Alkaloids of Norbelladine-Type as Inspiration for Development of Highly Selective Butyrylcholinesterase Inhibitors: Synthesis, Biological Activity Evaluation, and Docking Studies

Tacrine-resveratrol fused hybrids as multi-target-directed ligands against Alzheimer's disease

Amaryllidaceae alkaloids from Narcissus pseudonarcissus L. cv. Dutch Master as potential drugs in treatment of Alzheimer's disease

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