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REV-ERB and ROR nuclear receptors as drug targets

Nature reviews. Drug discovery, 2014-03, Vol.13 (3), p.197-216

2014

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Structural mechanism underlying ligand binding and activation of PPARγ

Structure (London), 2021-09, Vol.29 (9), p.940-950.e4

2021

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Go big and go home: A bulky extension makes promiscuous ligands settle down

Structure (London), 2023-12, Vol.31 (12), p.1520-1522

2023

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Small molecule modulation of nuclear receptor conformational dynamics: implications for function and drug discovery

Molecular pharmacology, 2013-01, Vol.83 (1), p.1-8

2013

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Molecular basis of ligand-dependent Nurr1-RXRα activation

eLife, 2023-04, Vol.12

2023

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Activity-Based Profiling Reveals a Regulatory Link between Oxidative Stress and Protein Arginine Phosphorylation

Cell chemical biology, 2016-08, Vol.23 (8), p.967-977

2016

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A molecular switch regulating transcriptional repression and activation of PPARγ

Nature communications, 2020-02, Vol.11 (1), p.956-956, Article 956

2020

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Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements

Nature communications, 2018-04, Vol.9 (1), p.1337-13, Article 1337

2018

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Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

Nature (London), 2012-05, Vol.485 (7396), p.62-68

2012

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Nuclear receptors and their selective pharmacologic modulators

Pharmacological reviews, 2013-04, Vol.65 (2), p.710-778

2013

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Regulation of p53 stability and apoptosis by a ROR agonist

PloS one, 2012-04, Vol.7 (4), p.e34921

2012

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Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1

Journal of medicinal chemistry, 2020-12, Vol.63 (24), p.15639-15654

2020

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Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication

Antimicrobial agents and chemotherapy, 2016-04, Vol.60 (4), p.2195-2208

2016

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Structural mechanism for signal transduction in RXR nuclear receptor heterodimers

Nature communications, 2015-08, Vol.6 (1), p.8013-8013, Article 8013

2015

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Quantitative structural assessment of graded receptor agonism

Proceedings of the National Academy of Sciences - PNAS, 2019-10, Vol.116 (44), p.22179-22188

2019

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CAR directs T cell adaptation to bile acids in the small intestine

Nature (London), 2021-05, Vol.593 (7857), p.147-151

2021

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Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ

eLife, 2018-12, Vol.7 (12, 2018)

2018

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Conserved sequence-specific lincRNA–steroid receptor interactions drive transcriptional repression and direct cell fate

Nature communications, 2014-11, Vol.5 (1), p.5395-5395, Article 5395

2014

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A structural mechanism for directing corepressor-selective inverse agonism of PPARγ

Nature communications, 2018-11, Vol.9 (1), p.4687-14, Article 4687

2018

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Ligand and Receptor Dynamics Contribute to the Mechanism of Graded PPARγ Agonism

Structure (London), 2012-01, Vol.20 (1), p.139-150

2012

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Defining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1

Structure (London), 2019-01, Vol.27 (1), p.66-77.e5

2019

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Phosphatidylserine orchestrates Myomerger membrane insertions to drive myoblast fusion

Proceedings of the National Academy of Sciences - PNAS, 2022-09, Vol.119 (38), p.e2202490119

2022

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DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex

Nature structural & molecular biology, 2011-05, Vol.18 (5), p.556-563

2011

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An alternate binding site for PPARγ ligands

Nature communications, 2014-04, Vol.5 (1), p.3571-3571, Article 3571

2014

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Structure-Activity Relationship and Biological Investigation of a REV-ERBα-Selective Agonist SR-29065 ( 34 ) for Autoimmune Disorders

Journal of medicinal chemistry, 2023-11, Vol.66 (21), p.14815-14823

2023

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REV-ERB and ROR nuclear receptors as drug targets

Structural mechanism underlying ligand binding and activation of PPARγ

Go big and go home: A bulky extension makes promiscuous ligands settle down

Small molecule modulation of nuclear receptor conformational dynamics: implications for function and drug discovery

Molecular basis of ligand-dependent Nurr1-RXRα activation

Activity-Based Profiling Reveals a Regulatory Link between Oxidative Stress and Protein Arginine Phosphorylation

A molecular switch regulating transcriptional repression and activation of PPARγ

Cryptic glucocorticoid receptor-binding sites pervade genomic NF-κB response elements

Regulation of circadian behaviour and metabolism by synthetic REV-ERB agonists

Nuclear receptors and their selective pharmacologic modulators

Regulation of p53 stability and apoptosis by a ROR agonist

Assessment of NR4A Ligands That Directly Bind and Modulate the Orphan Nuclear Receptor Nurr1

Ebselen, a Small-Molecule Capsid Inhibitor of HIV-1 Replication

Structural mechanism for signal transduction in RXR nuclear receptor heterodimers

Quantitative structural assessment of graded receptor agonism

CAR directs T cell adaptation to bile acids in the small intestine

Cooperative cobinding of synthetic and natural ligands to the nuclear receptor PPARγ

Conserved sequence-specific lincRNA–steroid receptor interactions drive transcriptional repression and direct cell fate

A structural mechanism for directing corepressor-selective inverse agonism of PPARγ

Ligand and Receptor Dynamics Contribute to the Mechanism of Graded PPARγ Agonism

Defining a Canonical Ligand-Binding Pocket in the Orphan Nuclear Receptor Nurr1

Phosphatidylserine orchestrates Myomerger membrane insertions to drive myoblast fusion

DNA binding alters coactivator interaction surfaces of the intact VDR-RXR complex

An alternate binding site for PPARγ ligands

Structure-Activity Relationship and Biological Investigation of a REV-ERBα-Selective Agonist SR-29065 ( 34 ) for Autoimmune Disorders

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