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2-Oxoglutarate-dependent dioxygenases in cancer

Nature reviews. Cancer, 2020-12, Vol.20 (12), p.710-726

2020

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Higher hemoglobin levels are an independent risk factor for adverse metabolism and higher mortality in a 20-year follow-up

Scientific reports, 2021-10, Vol.11 (1), p.19936-19936, Article 19936

2021

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Higher hemoglobin levels are an independent risk factor for gestational diabetes

Scientific reports, 2022-01, Vol.12 (1), p.1686-1686, Article 1686

2022

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Hypoxia-inducible factor prolyl 4-hydroxylases: common and specific roles

Biological chemistry, 2013-04, Vol.394 (4), p.435-448

2013

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Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

Science (American Association for the Advancement of Science), 2019-03, Vol.363 (6432), p.1217-1222

2019

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(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

Science (American Association for the Advancement of Science), 2013-03, Vol.339 (6127), p.1621-1625

2013

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PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

Nature communications, 2020-01, Vol.11 (1), p.174-174, Article 174

2020

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Transformation by the (R)―enantiomer of 2-hydroxyglutarate linked to EGLN activation

Nature (London), 2012-03, Vol.483 (7390), p.484-488

2012

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Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

Cell, 2016-06, Vol.166 (1), p.126-139

2016

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A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue

eLife, 2024-09, Vol.12

2024

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Hemoglobin levels are associated with retinal vascular caliber in a middle-aged birth cohort

Scientific reports, 2024-04, Vol.14 (1), p.9092-9092, Article 9092

2024

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Structural basis of homo- and heterotrimerization of collagen I

Nature communications, 2017-03, Vol.8 (1), p.14671-10, Article 14671

2017

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Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis

Arteriosclerosis, thrombosis, and vascular biology, 2016-04, Vol.36 (4), p.608-617

2016

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Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice

PloS one, 2020-05, Vol.15 (5), p.e0233261-e0233261

2020

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HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction

Diabetes (New York, N.Y.), 2014-10, Vol.63 (10), p.3324-3333

2014

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Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism

Scientific reports, 2018-09, Vol.8 (1), p.13583-13583, Article 13583

2018

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HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD

Journal of molecular medicine (Berlin, Germany), 2020-05, Vol.98 (5), p.719-731

2020

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Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor

The Journal of biological chemistry, 2003-08, Vol.278 (33), p.30772-30780

2003

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The TET enzymes

Cellular and molecular life sciences : CMLS, 2018-04, Vol.75 (8), p.1339-1348

2018

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Author Correction: Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism

Scientific reports, 2020-03, Vol.10 (1), p.4260-4260, Article 4260

2020

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Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen

Cell reports (Cambridge), 2015-12, Vol.13 (10), p.2048-2055

2015

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Expression and Roles of Individual HIF Prolyl 4-Hydroxylase Isoenzymes in the Regulation of the Hypoxia Response Pathway along the Murine Gastrointestinal Epithelium

International journal of molecular sciences, 2021-04, Vol.22 (8), p.4038

2021

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Characterization of genetic variants in the EGLN1/PHD2 gene identified in a European collection of patients with erythrocytosis

Haematologica (Roma), 2023-11, Vol.108 (11), p.3068-3085

2023

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Catalytic Properties of the Asparaginyl Hydroxylase (FIH) in the Oxygen Sensing Pathway Are Distinct from Those of Its Prolyl 4-Hydroxylases

The Journal of biological chemistry, 2004-03, Vol.279 (11), p.9899-9904

2004

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USP28 Deficiency Promotes Breast and Liver Carcinogenesis as well as Tumor Angiogenesis in a HIF-independent Manner

Molecular cancer research, 2018-06, Vol.16 (6), p.1000-1012

2018

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2-Oxoglutarate-dependent dioxygenases in cancer

Higher hemoglobin levels are an independent risk factor for adverse metabolism and higher mortality in a 20-year follow-up

Higher hemoglobin levels are an independent risk factor for gestational diabetes

Hypoxia-inducible factor prolyl 4-hydroxylases: common and specific roles

Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate

(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible

PHD1 controls muscle mTORC1 in a hydroxylation-independent manner by stabilizing leucyl tRNA synthetase

Transformation by the (R)―enantiomer of 2-hydroxyglutarate linked to EGLN activation

Paracrine Induction of HIF by Glutamate in Breast Cancer: EglN1 Senses Cysteine

A 2-hydroxybutyrate-mediated feedback loop regulates muscular fatigue

Hemoglobin levels are associated with retinal vascular caliber in a middle-aged birth cohort

Structural basis of homo- and heterotrimerization of collagen I

Hypoxia-Inducible Factor Prolyl 4-Hydroxylase-2 Inhibition Protects Against Development of Atherosclerosis

Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice

HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction

Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism

HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD

Characterization of the Human Prolyl 4-Hydroxylases That Modify the Hypoxia-inducible Factor

The TET enzymes

Author Correction: Hypoxia causes reductions in birth weight by altering maternal glucose and lipid metabolism

Ferritin-Mediated Iron Sequestration Stabilizes Hypoxia-Inducible Factor-1α upon LPS Activation in the Presence of Ample Oxygen

Expression and Roles of Individual HIF Prolyl 4-Hydroxylase Isoenzymes in the Regulation of the Hypoxia Response Pathway along the Murine Gastrointestinal Epithelium

Characterization of genetic variants in the EGLN1/PHD2 gene identified in a European collection of patients with erythrocytosis

Catalytic Properties of the Asparaginyl Hydroxylase (FIH) in the Oxygen Sensing Pathway Are Distinct from Those of Its Prolyl 4-Hydroxylases

USP28 Deficiency Promotes Breast and Liver Carcinogenesis as well as Tumor Angiogenesis in a HIF-independent Manner

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