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Human Mitochondrial Topoisomerase I

Proceedings of the National Academy of Sciences - PNAS, 2001-09, Vol.98 (19), p.10608-10613

2001

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ABCG2 mediates differential resistance to SN-38 (7-ethyl-10-hydroxycamptothecin) and homocamptothecins

The Journal of pharmacology and experimental therapeutics, 2004-08, Vol.310 (2), p.836

2004

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Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison

Molecular pharmacology, 2005-02, Vol.67 (2), p.523-530

2005

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Synthesis of New Dihydroindeno[1,2-c]isoquinoline and Indenoisoquinolinium Chloride Topoisomerase I Inhibitors Having High in Vivo Anticancer Activity in the Hollow Fiber Animal Model

Journal of medicinal chemistry, 2002-01, Vol.45 (1), p.242-249

2002

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Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors

Bioorganic & medicinal chemistry, 2004-10, Vol.12 (19), p.5147-5160

2004

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Apoptotic Topoisomerase I-DNA Complexes Induced by Staurosporine-mediated Oxygen Radicals

The Journal of biological chemistry, 2004-11, Vol.279 (48), p.50499-50504

2004

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Protein-Linked DNA Strand Breaks Induced by NSC 314622, a Novel Noncamptothecin Topoisomerase I Poison

Molecular pharmacology, 1998-07, Vol.54 (1), p.50-58

1998

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DNA Sequence- and Structure-Selective Alkylation of Guanine N2 in the DNA Minor Groove by Ecteinascidin 743, a Potent Antitumor Compound from the Caribbean Tunicate Ecteinascidia turbinata

Biochemistry (Easton), 1996-10, Vol.35 (41), p.13303-13309

1996

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The Novel Silatecan 7-tert-Butyldimethylsilyl-10-hydroxycamptothecin Displays High Lipophilicity, Improved Human Blood Stability, and Potent Anticancer Activity

Journal of medicinal chemistry, 2000-10, Vol.43 (21), p.3970-3980

2000

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Gemcitabine (2′,2′-Difluoro-2′-Deoxycytidine), an Antimetabolite That Poisons Topoisomerase I

Clinical cancer research, 2002-08, Vol.8 (8), p.2499-2504

2002

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Induction of Topoisomerase I Cleavage Complexes by 1-β -D-Arabinofuranosylcytosine (ara-C) in vitro and in Ara-C-Treated Cells

Proceedings of the National Academy of Sciences - PNAS, 2000-02, Vol.97 (4), p.1885-1890

2000

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Effects of Uracil Incorporation, DNA Mismatches, and Abasic Sites on Cleavage and Religation Activities of Mammalian Topoisomerase I

The Journal of biological chemistry, 1997-03, Vol.272 (12), p.7792-7796

1997

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Poisoning of Human DNA Topoisomerase I by Ecteinascidin 743, an Anticancer Drug That Selectively Alkylates DNA in the Minor Groove

Proceedings of the National Academy of Sciences - PNAS, 1999-06, Vol.96 (13), p.7196-7201

1999

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Topoisomerase I-DNA Complexes Contribute to Arsenic Trioxide-induced Apoptosis

The Journal of biological chemistry, 2004-08, Vol.279 (32), p.33968-33975

2004

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Ecteinascidin 743 Induces Protein-linked DNA Breaks in Human Colon Carcinoma HCT116 Cells and Is Cytotoxic Independently of Topoisomerase I Expression

Clinical cancer research, 2001-01, Vol.7 (1), p.185-191

2001

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Benzo[a]pyrene Diol Epoxide Adducts in DNA Are Potent Suppressors of a Normal Topoisomerase I Cleavage Site and Powerful Inducers of other Topoisomerase I Cleavages

Proceedings of the National Academy of Sciences - PNAS, 2000-02, Vol.97 (5), p.2040-2045

2000

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Phosphorylation of DNA Topoisomerase I by the c-Abl Tyrosine Kinase Confers Camptothecin Sensitivity

The Journal of biological chemistry, 2004-12, Vol.279 (50), p.51851-51861

2004

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Position-Specific Trapping of Topoisomerase II by Benzo[a]pyrene Diol Epoxide Adducts: Implications for Interactions with Intercalating Anticancer Agents

Proceedings of the National Academy of Sciences - PNAS, 2003-10, Vol.100 (21), p.12498-12503

2003

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Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA

Cancer research (Chicago, Ill.), 2003-11, Vol.63 (21), p.7291-7300

2003

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Position-Specific Trapping of Topoisomerase I-DNA Cleavage Complexes by Intercalated Benzo[a]-Pyrene Diol Epoxide Adducts at the 6-Amino Group of Adenine

Proceedings of the National Academy of Sciences - PNAS, 2000-09, Vol.97 (20), p.10739-10744

2000

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Different Effects on Human Topoisomerase I by Minor Groove and Intercalated Deoxyguanosine Adducts Derived from Two Polycyclic Aromatic Hydrocarbon Diol Epoxides at or Near a Normal Cleavage Site

The Journal of biological chemistry, 2002-04, Vol.277 (16), p.13666-13672

2002

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Topoisomerase Poisoning Activity of Novel Disaccharide Anthracyclines

Molecular pharmacology, 1999-07, Vol.56 (1), p.77-84

1999

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In vitro evaluation of dimethane sulfonate analogues with potential alkylating activity and selective renal cell carcinoma cytotoxicity

Molecular cancer therapeutics, 2004-07, Vol.3 (7), p.849-860

2004

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DNA Protein Cross-Links Produced by NSC 652287, a Novel Thiophene Derivative Active Against Human Renal Cancer Cells

Molecular pharmacology, 1999-09, Vol.56 (3), p.478-484

1999

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Cellular Determinants of Sensitivity and Resistance to DNA Topoisomerase Inhibitors

Cancer investigation, 1994, Vol.12 (5), p.530-542

1994

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Human Mitochondrial Topoisomerase I

ABCG2 mediates differential resistance to SN-38 (7-ethyl-10-hydroxycamptothecin) and homocamptothecins

Cellular Topoisomerase I Inhibition and Antiproliferative Activity by MJ-III-65 (NSC 706744), an Indenoisoquinoline Topoisomerase I Poison

Synthesis of New Dihydroindeno[1,2-c]isoquinoline and Indenoisoquinolinium Chloride Topoisomerase I Inhibitors Having High in Vivo Anticancer Activity in the Hollow Fiber Animal Model

Design, synthesis, and biological evaluation of cytotoxic 11-aminoalkenylindenoisoquinoline and 11-diaminoalkenylindenoisoquinoline topoisomerase I inhibitors

Apoptotic Topoisomerase I-DNA Complexes Induced by Staurosporine-mediated Oxygen Radicals

Protein-Linked DNA Strand Breaks Induced by NSC 314622, a Novel Noncamptothecin Topoisomerase I Poison

DNA Sequence- and Structure-Selective Alkylation of Guanine N2 in the DNA Minor Groove by Ecteinascidin 743, a Potent Antitumor Compound from the Caribbean Tunicate Ecteinascidia turbinata

The Novel Silatecan 7-tert-Butyldimethylsilyl-10-hydroxycamptothecin Displays High Lipophilicity, Improved Human Blood Stability, and Potent Anticancer Activity

Gemcitabine (2′,2′-Difluoro-2′-Deoxycytidine), an Antimetabolite That Poisons Topoisomerase I

Induction of Topoisomerase I Cleavage Complexes by 1-β -D-Arabinofuranosylcytosine (ara-C) in vitro and in Ara-C-Treated Cells

Effects of Uracil Incorporation, DNA Mismatches, and Abasic Sites on Cleavage and Religation Activities of Mammalian Topoisomerase I

Poisoning of Human DNA Topoisomerase I by Ecteinascidin 743, an Anticancer Drug That Selectively Alkylates DNA in the Minor Groove

Topoisomerase I-DNA Complexes Contribute to Arsenic Trioxide-induced Apoptosis

Ecteinascidin 743 Induces Protein-linked DNA Breaks in Human Colon Carcinoma HCT116 Cells and Is Cytotoxic Independently of Topoisomerase I Expression

Benzo[a]pyrene Diol Epoxide Adducts in DNA Are Potent Suppressors of a Normal Topoisomerase I Cleavage Site and Powerful Inducers of other Topoisomerase I Cleavages

Phosphorylation of DNA Topoisomerase I by the c-Abl Tyrosine Kinase Confers Camptothecin Sensitivity

Position-Specific Trapping of Topoisomerase II by Benzo[a]pyrene Diol Epoxide Adducts: Implications for Interactions with Intercalating Anticancer Agents

Inhibition of histone deacetylase increases cytotoxicity to anticancer drugs targeting DNA

Position-Specific Trapping of Topoisomerase I-DNA Cleavage Complexes by Intercalated Benzo[a]-Pyrene Diol Epoxide Adducts at the 6-Amino Group of Adenine

Different Effects on Human Topoisomerase I by Minor Groove and Intercalated Deoxyguanosine Adducts Derived from Two Polycyclic Aromatic Hydrocarbon Diol Epoxides at or Near a Normal Cleavage Site

Topoisomerase Poisoning Activity of Novel Disaccharide Anthracyclines

In vitro evaluation of dimethane sulfonate analogues with potential alkylating activity and selective renal cell carcinoma cytotoxicity

DNA Protein Cross-Links Produced by NSC 652287, a Novel Thiophene Derivative Active Against Human Renal Cancer Cells

Cellular Determinants of Sensitivity and Resistance to DNA Topoisomerase Inhibitors

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