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Down‐regulation of the Notch pathway mediated by a γ‐secretase inhibitor induces anti‐tumour effects in mouse models of T‐cell leukaemia

British journal of pharmacology, 2009-11, Vol.158 (5), p.1183-1195

2009

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Active Human Immunodeficiency Virus Protease is Required for Viral Infectivity

Proceedings of the National Academy of Sciences - PNAS, 1988-07, Vol.85 (13), p.4686-4690

1988

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Selective Inhibition of ras-Dependent Transformation by a Farnesyltransferase Inhibitor

Science (American Association for the Advancement of Science), 1993-06, Vol.260 (5116), p.1934-1937

1993

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Protein Farnesyltransferase Inhibitors Block the Growth of ras-Dependent Tumors in Nude Mice

Proceedings of the National Academy of Sciences - PNAS, 1994-09, Vol.91 (19), p.9141-9145

1994

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Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice

Cancer research (Chicago, Ill.), 1998-03, Vol.58 (6), p.1253-1259

1998

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Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo

The Journal of biological chemistry, 1993-04, Vol.268 (11), p.7617-7620

1993

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In vitro and In vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells

Blood, 1999-10, Vol.94 (7), p.2469-2476

1999

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Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

Molecular and Cellular Biology, 1994-06, Vol.14 (6), p.4193-4202

1994

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cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I

The Journal of biological chemistry, 1994-02, Vol.269 (5), p.3175-3180

1994

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Evaluation of farnesyl:Protein transferase and geranylgeranyl:Protein transferase inhibitor combinations in preclinical models

Cancer research (Chicago, Ill.), 2001-12, Vol.61 (24), p.8758-8768

2001

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Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

Cell, 1994-04, Vol.77 (2), p.175-178

1994

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Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase

Bioorganic & medicinal chemistry letters, 1999-12, Vol.9 (23), p.3301-3306

1999

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Treatment with Farnesyl-Protein Transferase Inhibitor Induces Regression of Mammary Tumors in Transforming Growth Factor (TGF) α and TGFα/neu Transgenic Mice by Inhibition of Mitogenic Activity and Induction of Apoptosis

Clinical cancer research, 1999-01, Vol.5 (1), p.35-42

1999

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Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

Cell, 1994-04, Vol.77 (2), p.175-178

1994

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Characterization of recombinant human farnesyl-protein transferase: Cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases

Biochemistry (Easton), 1993-05, Vol.32 (19), p.5167-5176

1993

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Design and in Vivo Analysis of Potent Non-Thiol Inhibitors of Farnesyl Protein Transferase

Journal of medicinal chemistry, 1999-08, Vol.42 (17), p.3356-3368

1999

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Farnesyl Transferase Inhibitors Cause Enhanced Mitotic Sensitivity to Taxol and Epothilones

Proceedings of the National Academy of Sciences - PNAS, 1998-02, Vol.95 (4), p.1369-1374

1998

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Structural homology among mammalian and Saccharomyces cerevisiae isoprenyl-protein transferases

The Journal of biological chemistry, 1991-10, Vol.266 (28), p.18884-18888

1991

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cDNA cloning and expression of bovine aspartyl (asparaginyl) beta-hydroxylase

The Journal of biological chemistry, 1992-07, Vol.267 (20), p.14322-14327

1992

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Differential expression of myc family genes during murine development

Nature (London), 1986-02, Vol.319 (6056), p.780-783

1986

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Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

Nature medicine, 1995-08, Vol.1 (8), p.792-797

1995

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N-myc Can Cooperate with ras to Transform Normal Cells in Culture

Proceedings of the National Academy of Sciences - PNAS, 1985-08, Vol.82 (16), p.5455-5459

1985

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Structure and Expression of the Murine N-myc Gene

Proceedings of the National Academy of Sciences - PNAS, 1986-03, Vol.83 (6), p.1827-1831

1986

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Transposition and amplification of oncogene-related sequences in human neuroblastomas

Cell, 1983-12, Vol.35 (2), p.359-367

1983

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NVL-330 is a selective, brain-penetrant inhibitor of oncogenic HER2 exon 20 insertion mutations in preclinical models

European journal of cancer (1990), 2022-10, Vol.174, p.S76-S77

2022

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Down‐regulation of the Notch pathway mediated by a γ‐secretase inhibitor induces anti‐tumour effects in mouse models of T‐cell leukaemia

Active Human Immunodeficiency Virus Protease is Required for Viral Infectivity

Selective Inhibition of ras-Dependent Transformation by a Farnesyltransferase Inhibitor

Protein Farnesyltransferase Inhibitors Block the Growth of ras-Dependent Tumors in Nude Mice

Antitumor effect of a farnesyl protein transferase inhibitor in mammary and lymphoid tumors overexpressing N-ras in transgenic mice

Selective inhibition of farnesyl-protein transferase blocks ras processing in vivo

In vitro and In vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells

Farnesyltransferase inhibition causes morphological reversion of ras-transformed cells by a complex mechanism that involves regulation of the actin cytoskeleton

cDNA cloning and expression of rat and human protein geranylgeranyltransferase type-I

Evaluation of farnesyl:Protein transferase and geranylgeranyl:Protein transferase inhibitor combinations in preclinical models

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

Imidazole-containing diarylether and diarylsulfone inhibitors of farnesyl-protein transferase

Treatment with Farnesyl-Protein Transferase Inhibitor Induces Regression of Mammary Tumors in Transforming Growth Factor (TGF) α and TGFα/neu Transgenic Mice by Inhibition of Mitogenic Activity and Induction of Apoptosis

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

Characterization of recombinant human farnesyl-protein transferase: Cloning, expression, farnesyl diphosphate binding, and functional homology with yeast prenyl-protein transferases

Design and in Vivo Analysis of Potent Non-Thiol Inhibitors of Farnesyl Protein Transferase

Farnesyl Transferase Inhibitors Cause Enhanced Mitotic Sensitivity to Taxol and Epothilones

Structural homology among mammalian and Saccharomyces cerevisiae isoprenyl-protein transferases

cDNA cloning and expression of bovine aspartyl (asparaginyl) beta-hydroxylase

Differential expression of myc family genes during murine development

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

N-myc Can Cooperate with ras to Transform Normal Cells in Culture

Structure and Expression of the Murine N-myc Gene

Transposition and amplification of oncogene-related sequences in human neuroblastomas

NVL-330 is a selective, brain-penetrant inhibitor of oncogenic HER2 exon 20 insertion mutations in preclinical models

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