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New concept of the glucagon‐like peptide‐1 signaling pathway on pancreatic insulin secretion

Journal of diabetes investigation, 2020-03, Vol.11 (2), p.265-267

Kaku, Kohei

2020

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Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History

International journal of molecular sciences, 2021-03, Vol.22 (5), p.2596

2021

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New prospects for incretin‐related drugs in the treatment of type 2 diabetes

Journal of diabetes investigation, 2021-07, Vol.12 (7), p.1141-1143

2021

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Benefit-Risk Assessment of Alogliptin for the Treatment of Type 2 Diabetes Mellitus

Drug safety, 2019-11, Vol.42 (11), p.1311-1327

2019

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Clinical relevance of dual agonist of glucagon and glucagon‐like peptide‐1 receptors to achieve functional restoration of first‐ and second‐phase insulin secretion

Journal of diabetes investigation, 2022-08, Vol.13 (8), p.1300-1302

2022

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Dulaglutide exerts beneficial anti atherosclerotic effects in ApoE knockout mice with diabetes: the earlier, the better

Scientific reports, 2021-01, Vol.11 (1), p.1425-12, Article 1425

2021

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Comparison of the effects of three kinds of glucose‐lowering drugs on non‐alcoholic fatty liver disease in patients with type 2 diabetes: A randomized, open‐label, three‐arm, active control study

Journal of diabetes investigation, 2020-11, Vol.11 (6), p.1612-1622

2020

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GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

The Journal of clinical investigation, 2015-12, Vol.125 (12), p.4714-4728

2015

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Early combination therapy of empagliflozin and linagliptin exerts beneficial effects on pancreatic β cells in diabetic db/db mice

Scientific reports, 2021-08, Vol.11 (1), p.16120-16120, Article 16120

2021

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Voglibose for prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese individuals with impaired glucose tolerance

The Lancet (British edition), 2009-05, Vol.373 (9675), p.1607-1614

2009

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Imeglimin exerts favorable effects on pancreatic β-cells by improving morphology in mitochondria and increasing the number of insulin granules

Scientific reports, 2022-08, Vol.12 (1), p.13220-13220, Article 13220

2022

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Unexpected Pleiotropic Effects of SGLT2 Inhibitors: Pearls and Pitfalls of This Novel Antidiabetic Class

International journal of molecular sciences, 2021-03, Vol.22 (6), p.3062

2021

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Factors contributing to the clinical effectiveness of imeglimin monotherapy in Japanese patients with type 2 diabetes mellitus

Journal of diabetes investigation, 2024-09, Vol.15 (9), p.1239-1247

2024

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Efficacy and safety of once‐weekly semaglutide in Japanese individuals with type 2 diabetes by baseline age and body mass index

Journal of diabetes investigation, 2022-07, Vol.13 (7), p.1161-1174

2022

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Efficacy, safety and tolerability of imeglimin in patients with type 2 diabetes mellitus: A meta‐analysis of randomized controlled trials

Journal of diabetes investigation, 2023-11, Vol.14 (11), p.1246-1261

2023

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Effect of patient characteristics on the efficacy and safety of imeglimin monotherapy in Japanese patients with type 2 diabetes mellitus: A post‐hoc analysis of two randomized, placebo‐controlled trials

Journal of diabetes investigation, 2023-09, Vol.14 (9), p.1101-1109

2023

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Favorable Effects of GLP-1 Receptor Agonist against Pancreatic β-Cell Glucose Toxicity and the Development of Arteriosclerosis: “The Earlier, the Better” in Therapy with Incretin-Based Medicine

International journal of molecular sciences, 2021-08, Vol.22 (15), p.7917

2021

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Case Report: Markedly Long-Term Preservation of Pancreatic β-Cell Function in a Subject With Elderly Onset of Type 1 Diabetes Mellitus Showing High-Titer Autoimmune Antibodies for Over 4 Years

Frontiers in immunology, 2021-11, Vol.12, p.752423

2021

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Long‐term (52‐week) efficacy and safety of ipragliflozin add‐on therapy to insulin in Japanese patients with type 1 diabetes mellitus: An uncontrolled, open‐label extension of a phase III study

Journal of diabetes investigation, 2020-05, Vol.11 (3), p.662-671

2020

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Influence of Nutritional Guidance/Consulting on Glycemic Control during the Coronavirus Disease 2019 Pandemic in Patients with Type 2 Diabetes Mellitus

Internal Medicine, 2023/03/15, Vol.62(6), pp.833-838

2023

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Pancreatic alpha cells in diabetic rats express active GLP-1 receptor: Endosomal co-localization of GLP-1/GLP-1R complex functioning through intra-islet paracrine mechanism

Scientific reports, 2018-02, Vol.8 (1), p.3725-14, Article 3725

2018

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Clinical findings of acute necrotizing esophagitis complicated by diabetic ketoacidosis

Endocrine Journal, 2024, Vol.71(5), pp.481-488

2024

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Renal effects of a sodium‐glucose cotransporter 2 inhibitor, tofogliflozin, in relation to sodium intake and glycaemic status

Diabetes, obesity & metabolism, 2019-07, Vol.21 (7), p.1715-1724

2019

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Once-weekly trelagliptin versus daily alogliptin in Japanese patients with type 2 diabetes: a randomised, double-blind, phase 3, non-inferiority study

The lancet. Diabetes & endocrinology, 2015-03, Vol.3 (3), p.191-197

2015

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Genome-wide association study identifies three novel loci for type 2 diabetes

Human molecular genetics, 2014-01, Vol.23 (1), p.239-246

2014

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New concept of the glucagon‐like peptide‐1 signaling pathway on pancreatic insulin secretion

Multifaceted Mechanisms of Action of Metformin Which Have Been Unraveled One after Another in the Long History

New prospects for incretin‐related drugs in the treatment of type 2 diabetes

Benefit-Risk Assessment of Alogliptin for the Treatment of Type 2 Diabetes Mellitus

Clinical relevance of dual agonist of glucagon and glucagon‐like peptide‐1 receptors to achieve functional restoration of first‐ and second‐phase insulin secretion

Dulaglutide exerts beneficial anti atherosclerotic effects in ApoE knockout mice with diabetes: the earlier, the better

Comparison of the effects of three kinds of glucose‐lowering drugs on non‐alcoholic fatty liver disease in patients with type 2 diabetes: A randomized, open‐label, three‐arm, active control study

GLP-1 stimulates insulin secretion by PKC-dependent TRPM4 and TRPM5 activation

Early combination therapy of empagliflozin and linagliptin exerts beneficial effects on pancreatic β cells in diabetic db/db mice

Voglibose for prevention of type 2 diabetes mellitus: a randomised, double-blind trial in Japanese individuals with impaired glucose tolerance

Imeglimin exerts favorable effects on pancreatic β-cells by improving morphology in mitochondria and increasing the number of insulin granules

Unexpected Pleiotropic Effects of SGLT2 Inhibitors: Pearls and Pitfalls of This Novel Antidiabetic Class

Factors contributing to the clinical effectiveness of imeglimin monotherapy in Japanese patients with type 2 diabetes mellitus

Efficacy and safety of once‐weekly semaglutide in Japanese individuals with type 2 diabetes by baseline age and body mass index

Efficacy, safety and tolerability of imeglimin in patients with type 2 diabetes mellitus: A meta‐analysis of randomized controlled trials

Effect of patient characteristics on the efficacy and safety of imeglimin monotherapy in Japanese patients with type 2 diabetes mellitus: A post‐hoc analysis of two randomized, placebo‐controlled trials

Favorable Effects of GLP-1 Receptor Agonist against Pancreatic β-Cell Glucose Toxicity and the Development of Arteriosclerosis: “The Earlier, the Better” in Therapy with Incretin-Based Medicine

Case Report: Markedly Long-Term Preservation of Pancreatic β-Cell Function in a Subject With Elderly Onset of Type 1 Diabetes Mellitus Showing High-Titer Autoimmune Antibodies for Over 4 Years

Long‐term (52‐week) efficacy and safety of ipragliflozin add‐on therapy to insulin in Japanese patients with type 1 diabetes mellitus: An uncontrolled, open‐label extension of a phase III study

Influence of Nutritional Guidance/Consulting on Glycemic Control during the Coronavirus Disease 2019 Pandemic in Patients with Type 2 Diabetes Mellitus

Pancreatic alpha cells in diabetic rats express active GLP-1 receptor: Endosomal co-localization of GLP-1/GLP-1R complex functioning through intra-islet paracrine mechanism

Clinical findings of acute necrotizing esophagitis complicated by diabetic ketoacidosis

Renal effects of a sodium‐glucose cotransporter 2 inhibitor, tofogliflozin, in relation to sodium intake and glycaemic status

Once-weekly trelagliptin versus daily alogliptin in Japanese patients with type 2 diabetes: a randomised, double-blind, phase 3, non-inferiority study

Genome-wide association study identifies three novel loci for type 2 diabetes

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