UB Paderborn / Katalog / Suche / in CDI

BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition

Cancer discovery, 2021-01, Vol.11 (1), p.142-157

2021

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A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo

Nature communications, 2022-10, Vol.13 (1), p.5969-5969, Article 5969

2022

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Synthesis of Functionalized Diarylmethanes via a Copper-Catalyzed Cross-Coupling of Arylmagnesium Reagents with Benzylic Phosphates

Organic letters, 2006-08, Vol.8 (18), p.4121-4124

2006

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Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria

Nature communications, 2024-03, Vol.15 (1), p.2005-2005, Article 2005

2024

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Iron-Catalyzed Aryl-Aryl Cross-Couplings with Magnesium-Derived Copper Reagents

Angewandte Chemie (International ed.), 2005-03, Vol.44 (11), p.1654-1658

2005

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Asymmetric Construction of Rings A−D of Daphnicyclidin-Type Alkaloids

Organic letters, 2009-12, Vol.11 (24), p.5658-5661

2009

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Preparation of Aryl−Alkylamines via Electrophilic Amination of Functionalized Arylazo Tosylates with Alkylzinc Reagents

Organic letters, 2006-08, Vol.8 (17), p.3741-3744

2006

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Iron-catalyzed aryl-aryl cross-coupling reaction tolerating amides and unprotected quinolinones

Chemical communications (Cambridge, England), 2007-01 (19), p.1954-1956

2007

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Efficient Cross-Coupling of Functionalized Arylzinc Halides Catalyzed by a Nickel Chloride−Diethyl Phosphite System

Organic letters, 2005-10, Vol.7 (22), p.4871-4874

2005

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Discovery of Novel Spiro[3H‑indole-3,2′-pyrrolidin]-2(1H)‑one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction

Journal of medicinal chemistry, 2016-11, Vol.59 (22), p.10147-10162

2016

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One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS

Journal of medicinal chemistry, 2021-05, Vol.64 (10), p.6569-6580

2021

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Confounding Factors in Targeted Degradation of Short-Lived Proteins

ACS chemical biology, 2024-07, Vol.19 (7), p.1484-1494

2024

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A Chiral Pool Strategy for the Synthesis of a SMARCA2 Degrading PROTAC

Organic process research & development, 2024-04, Vol.28 (4), p.1239-1252

2024

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Getting a Grip on the Undrugged: Targeting β‐Catenin with Fragment‐Based Methods

ChemMedChem, 2021-05, Vol.16 (9), p.1420-1424

2021

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Abstract 1091: BI-3406 and BI 1701963: Potent and selective SOS1::KRAS inhibitors induce regressions in combination with MEK inhibitors or irinotecan

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.1091-1091

2020

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An efficient Negishi cross-coupling reaction catalyzed by nickel(II) and diethyl phosphite

Tetrahedron, 2006-08, Vol.62 (32), p.7521-7533

2006

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Abstract C133: Effective targeting of KRAS-driven tumors by the first-in-class, orally bioavailable SOS1::KRAS inhibitor BI-3406

Molecular cancer therapeutics, 2019-12, Vol.18 (12_Supplement), p.C133-C133

2019

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Synthesis of JOSIPHOS-type ligands via a diastereoselective three-component reaction and their application in asymmetric rhodium-catalyzed hydroborations

Tetrahedron: asymmetry, 2005-10, Vol.16 (20), p.3385-3393

2005

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Direct preparation of polyfunctional amino-substituted arylmagnesium reagents via an iodine-magnesium exchange reaction

Chemical communications (Cambridge, England), 2003-02 (3), p.396-397

2003

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Cover Picture: Iron-Catalyzed Aryl-Aryl Cross-Couplings with Magnesium-Derived Copper Reagents (Angew. Chem. Int. Ed. 11/2005)

Angewandte Chemie (International ed.), 2005-03, Vol.44 (11), p.1573-1573

2005

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Destruction with a Purpose: Targeted Protein Degradation in Drug Discovery

Inducing Targeted Protein Degradation, 2022

Cromm, Philipp

2022

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Eisenkatalysierte Aryl-Aryl-Kreuzkupplungen mit Kupferreagentien

Angewandte Chemie, 2005-03, Vol.117 (11), p.1682-1685

2005

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Titelbild: Eisenkatalysierte Aryl-Aryl-Kreuzkupplungen mit Kupferreagentien (Angew. Chem. 11/2005)

Angewandte Chemie, 2005-03, Vol.117 (11), p.1599-1599

2005

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BI-3406, a Potent and Selective SOS1-KRAS Interaction Inhibitor, Is Effective in KRAS-Driven Cancers through Combined MEK Inhibition

A selective and orally bioavailable VHL-recruiting PROTAC achieves SMARCA2 degradation in vivo

Synthesis of Functionalized Diarylmethanes via a Copper-Catalyzed Cross-Coupling of Arylmagnesium Reagents with Benzylic Phosphates

Homo-BacPROTAC-induced degradation of ClpC1 as a strategy against drug-resistant mycobacteria

Iron-Catalyzed Aryl-Aryl Cross-Couplings with Magnesium-Derived Copper Reagents

Asymmetric Construction of Rings A−D of Daphnicyclidin-Type Alkaloids

Preparation of Aryl−Alkylamines via Electrophilic Amination of Functionalized Arylazo Tosylates with Alkylzinc Reagents

Iron-catalyzed aryl-aryl cross-coupling reaction tolerating amides and unprotected quinolinones

Efficient Cross-Coupling of Functionalized Arylzinc Halides Catalyzed by a Nickel Chloride−Diethyl Phosphite System

Discovery of Novel Spiro[3H‑indole-3,2′-pyrrolidin]-2(1H)‑one Compounds as Chemically Stable and Orally Active Inhibitors of the MDM2–p53 Interaction

One Atom Makes All the Difference: Getting a Foot in the Door between SOS1 and KRAS

Confounding Factors in Targeted Degradation of Short-Lived Proteins

A Chiral Pool Strategy for the Synthesis of a SMARCA2 Degrading PROTAC

Getting a Grip on the Undrugged: Targeting β‐Catenin with Fragment‐Based Methods

Abstract 1091: BI-3406 and BI 1701963: Potent and selective SOS1::KRAS inhibitors induce regressions in combination with MEK inhibitors or irinotecan

An efficient Negishi cross-coupling reaction catalyzed by nickel(II) and diethyl phosphite

Abstract C133: Effective targeting of KRAS-driven tumors by the first-in-class, orally bioavailable SOS1::KRAS inhibitor BI-3406

Front Cover: Getting a Grip on the Undrugged: Targeting β‐Catenin with Fragment‐Based Methods (9/2021)

Getting a Grip on the Undrugged: Targeting [beta]-Catenin with Fragment-Based Methods

Synthesis of JOSIPHOS-type ligands via a diastereoselective three-component reaction and their application in asymmetric rhodium-catalyzed hydroborations

Direct preparation of polyfunctional amino-substituted arylmagnesium reagents via an iodine-magnesium exchange reaction

Cover Picture: Iron-Catalyzed Aryl-Aryl Cross-Couplings with Magnesium-Derived Copper Reagents (Angew. Chem. Int. Ed. 11/2005)

Destruction with a Purpose: Targeted Protein Degradation in Drug Discovery

Eisenkatalysierte Aryl-Aryl-Kreuzkupplungen mit Kupferreagentien

Titelbild: Eisenkatalysierte Aryl-Aryl-Kreuzkupplungen mit Kupferreagentien (Angew. Chem. 11/2005)

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