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BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer's Disease Pathology

Molecules (Basel, Switzerland), 2017-10, Vol.22 (10), p.1723

Koelsch, Gerald

2017

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Human Aspartic Protease Memapsin 2 Cleaves the β -Secretase Site of β -amyloid Precursor Protein

Proceedings of the National Academy of Sciences - PNAS, 2000-02, Vol.97 (4), p.1456-1460

2000

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Subsite Specificity of Memapsin 2 (β-Secretase): Implications for Inhibitor Design

Biochemistry (Easton), 2001-08, Vol.40 (34), p.10001-10006

2001

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Structure-Based Design: Potent Inhibitors of Human Brain Memapsin 2 (β-Secretase)

Journal of medicinal chemistry, 2001-08, Vol.44 (18), p.2865-2868

2001

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Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase)

Journal of the American Chemical Society, 2000-04, Vol.122 (14), p.3522-3523

2000

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Characterization of ASP8374, a fully-human, antagonistic anti-TIGIT monoclonal antibody

Cancer treatment and research communications, 2021, Vol.28, p.100433-100433, Article 100433

2021

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Memapsin 2 (β-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2

FEBS letters, 2002-07, Vol.524 (1), p.183-187

2002

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Structure-based design of cycloamide–urethane-derived novel inhibitors of human brain memapsin 2 (β-secretase)

Bioorganic & medicinal chemistry letters, 2005-01, Vol.15 (1), p.15-20

2005

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Genome Scan of Human Systemic Lupus Erythematosus: Evidence for Linkage on Chromosome 1q in African-American Pedigrees

Proceedings of the National Academy of Sciences - PNAS, 1998-12, Vol.95 (25), p.14869-14874

1998

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Memapsin 2 (beta-secretase) inhibitor drug, between fantasy and reality

Current Alzheimer research, 2007-09, Vol.4 (4), p.418

2007

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Internalization of Exogenously Added Memapsin 2 (β-Secretase) Ectodomain by Cells Is Mediated by Amyloid Precursor Protein

The Journal of biological chemistry, 2004-09, Vol.279 (36), p.37886-37894

2004

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β-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice

The FASEB journal, 2011-02, Vol.25 (2), p.775-784

2011

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Multiple functions of pro-parts of aspartic proteinase zymogens

FEBS Letters, 1994-04, Vol.343 (1), p.6-10

1994

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Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor

Science (American Association for the Advancement of Science), 2000-10, Vol.290 (5489), p.150-153

2000

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Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand

Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (3), p.668-672

2015

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Crystal Structure of Memapsin 2 (β-Secretase) in Complex with an Inhibitor OM00-3

Biochemistry (Easton), 2002-09, Vol.41 (36), p.10963-10967

2002

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APN0417: A potent and efficacious α7 nAChR positive allosteric modulator

Biochemical pharmacology, 2015-10, Vol.97 (4), p.636-636

2015

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Enzymic characteristics of secreted aspartic proteases of Candida albicans

Biochimica et biophysica acta, 2000-07, Vol.1480 (1), p.117-131

2000

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Design, Synthesis, and X-ray Structure of Potent Memapsin 2 (β-Secretase) Inhibitors with Isophthalamide Derivatives as the P2 -P3-Ligands

Journal of medicinal chemistry, 2007-05, Vol.50 (10), p.2399-2407

2007

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Potent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation

Bioorganic & medicinal chemistry, 2008-02, Vol.18 (3), p.1031-1036

2008

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Structural Locations and Functional Roles of New Subsites S 5 , S 6 , and S 7 in Memapsin 2 (β-Secretase)

Biochemistry (Easton), 2005-01, Vol.44 (1), p.105-112

2005

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In vivo inhibition of Aβ production by memapsin 2 (β‐secretase) inhibitors

Journal of neurochemistry, 2004-06, Vol.89 (6), p.1409-1416

2004

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APN1125: A clinical stage α7 nicotinic acetylcholine receptor partial agonist

Biochemical pharmacology, 2015-10, Vol.97 (4), p.636-636

2015

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Proteolytic Activation of Recombinant Pro-memapsin 2 (Pro-β-secretase) Studied with New Fluorogenic Substrates

Biochemistry (Easton), 2000-10, Vol.39 (40), p.12450-12456

2000

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Structural Locations and Functional Roles of New Subsites S5, S6, and S7 in Memapsin 2 (β-Secretase)

Biochemistry (Easton), 2005-01, Vol.44 (1), p.105-112

2005

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BACE1 Function and Inhibition: Implications of Intervention in the Amyloid Pathway of Alzheimer's Disease Pathology

Human Aspartic Protease Memapsin 2 Cleaves the β -Secretase Site of β -amyloid Precursor Protein

Subsite Specificity of Memapsin 2 (β-Secretase): Implications for Inhibitor Design

Structure-Based Design: Potent Inhibitors of Human Brain Memapsin 2 (β-Secretase)

Design of Potent Inhibitors for Human Brain Memapsin 2 (β-Secretase)

Characterization of ASP8374, a fully-human, antagonistic anti-TIGIT monoclonal antibody

Memapsin 2 (β-secretase) cytosolic domain binds to the VHS domains of GGA1 and GGA2: implications on the endocytosis mechanism of memapsin 2

Structure-based design of cycloamide–urethane-derived novel inhibitors of human brain memapsin 2 (β-secretase)

Genome Scan of Human Systemic Lupus Erythematosus: Evidence for Linkage on Chromosome 1q in African-American Pedigrees

Memapsin 2 (beta-secretase) inhibitor drug, between fantasy and reality

Internalization of Exogenously Added Memapsin 2 (β-Secretase) Ectodomain by Cells Is Mediated by Amyloid Precursor Protein

β-Secretase inhibitor GRL-8234 rescues age-related cognitive decline in APP transgenic mice

Multiple functions of pro-parts of aspartic proteinase zymogens

Structure of the Protease Domain of Memapsin 2 (β-Secretase) Complexed with Inhibitor

Structure-based design, synthesis and biological evaluation of novel β-secretase inhibitors containing a pyrazole or thiazole moiety as the P3 ligand

Crystal Structure of Memapsin 2 (β-Secretase) in Complex with an Inhibitor OM00-3

APN0417: A potent and efficacious α7 nAChR positive allosteric modulator

Enzymic characteristics of secreted aspartic proteases of Candida albicans

Design, Synthesis, and X-ray Structure of Potent Memapsin 2 (β-Secretase) Inhibitors with Isophthalamide Derivatives as the P2 -P3-Ligands

Potent memapsin 2 (β-secretase) inhibitors: Design, synthesis, protein-ligand X-ray structure, and in vivo evaluation

Structural Locations and Functional Roles of New Subsites S 5 , S 6 , and S 7 in Memapsin 2 (β-Secretase)

In vivo inhibition of Aβ production by memapsin 2 (β‐secretase) inhibitors

APN1125: A clinical stage α7 nicotinic acetylcholine receptor partial agonist

Proteolytic Activation of Recombinant Pro-memapsin 2 (Pro-β-secretase) Studied with New Fluorogenic Substrates

Structural Locations and Functional Roles of New Subsites S5, S6, and S7 in Memapsin 2 (β-Secretase)

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