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Three HIV Drugs, Atazanavir, Ritonavir, and Tenofovir, Coformulated in Drug-Combination Nanoparticles Exhibit Long-Acting and Lymphocyte-Targeting Properties in Nonhuman Primates
Journal of pharmaceutical sciences, 2018-12, Vol.107 (12), p.3153-3162
2018
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Long-acting three-drug combination anti-HIV nanoparticles enhance drug exposure in primate plasma and cells within lymph nodes and blood
AIDS (London), 2014-11, Vol.28 (17), p.2625-2627
2014
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Anti-HIV drug-combination nanoparticles enhance plasma drug exposure duration as well as triple-drug combination levels in cells within lymph nodes and blood in primates
AIDS research and human retroviruses, 2015-01, Vol.31 (1), p.107
2015
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Mechanism-based pharmacokinetic (MBPK) models describe the complex plasma kinetics of three antiretrovirals delivered by a long-acting anti-HIV drug combination nanoparticle formulation
Journal of controlled release, 2018-04, Vol.275, p.229-241
2018
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Long-acting combination anti-HIV drug suspension enhances and sustains higher drug levels in lymph node cells than in blood cells and plasma
AIDS (London), 2017-03, Vol.31 (6), p.765-770
2017
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Extended cell and plasma drug levels after one dose of a 3-in-1 nanosuspension containing lopinavir, efavirenz, and tenofovir in non-human primates
AIDS (London), 2018-11, Vol.32 (17), p.2463-2467
2018
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Extended cell and plasma drug levels after one dose of a three-in-one nanosuspension containing lopinavir, efavirenz, and tenofovir in nonhuman primates
AIDS (London), 2018-11, Vol.32 (17), p.2463-2467
2018
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Integration of Computational and Experimental Approaches to Elucidate Mechanisms of First-Pass Lymphatic Drug Sequestration and Long-Acting Pharmacokinetics of the Injectable Triple-HIV Drug Combination TLC-ART 101
Journal of pharmaceutical sciences, 2020-05, Vol.109 (5), p.1789-1801
2020
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Evaluation of Atazanavir and Darunavir Interactions with Lipids for Developing pH-Responsive Anti-HIV Drug Combination Nanoparticles
Journal of pharmaceutical sciences, 2014-08, Vol.103 (8), p.2520-2529
2014
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Nanodrug formulations to enhance HIV drug exposure in lymphoid tissues and cells: clinical significance and potential impact on treatment and eradication of HIV/AIDS
Nanomedicine, 2016-03, Vol.11 (5), p.545-564
2016
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A simple, efficient, and sensitive method for simultaneous detection of anti-HIV drugs atazanavir, ritonavir, and tenofovir by use of liquid chromatography-tandem mass spectrometry
Antimicrobial agents and chemotherapy, 2015-11, Vol.59 (11), p.6682-6688
2015
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Novel Liquid Chromatography-Tandem Mass Spectrometry Method for Simultaneous Detection of Anti-HIV Drugs Lopinavir, Ritonavir, and Tenofovir in Plasma
Antimicrobial agents and chemotherapy, 2014-05, Vol.58 (5), p.2675-2680
2014
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Long-acting three-drug combination anti-HIV nanoparticles enhance drug exposure in primate plasma and cells within lymph nodes and blood
AIDS (London), 2014, Vol.28 (17), p.2627-2629
2014
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Systems Approach to targeted and long-acting HIV/AIDS therapy
Drug delivery and translational research, 2015-12, Vol.5 (6), p.531-539
2015
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