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Modeling of the Bryostatins to the Phorbol Ester Pharmacophore on Protein Kinase C

Proceedings of the National Academy of Sciences - PNAS, 1988-10, Vol.85 (19), p.7197-7201

1988

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Analysis of the Phorbol Ester Pharmacophore on Protein Kinase C as a Guide to the Rational Design of New Classes of Analogs

Proceedings of the National Academy of Sciences - PNAS, 1986-06, Vol.83 (12), p.4214-4218

1986

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Development of a comprehensive pharmacophore model for the benzodiazepine receptor

Drug design and discovery, 1995-01, Vol.12 (3), p.193

1995

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Synthesis of benzo-fused benzodiazepines employed as probes of the agonist pharmacophore of benzodiazepine receptors

Journal of medicinal chemistry, 1994-03, Vol.37 (6), p.745-757

1994

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Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site

Journal of medicinal chemistry, 1990-09, Vol.33 (9), p.2343-2357

1990

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Development of subtype-selective oestrogen receptor-based therapeutics

Nature reviews. Drug discovery, 2011-10, Vol.10 (10), p.778-792

2011

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Predictive binding of .beta.-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach

Journal of medicinal chemistry, 1992-10, Vol.35 (22), p.4001-4010

1992

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Synthetic and computer assisted analysis of the pharmacophore for agonists at benzodiazepine receptors

Life sciences (1973), 1991, Vol.49 (3), p.207-216

1991

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Determination of the Structure and Chiroptical Properties of the Parent Nerve Gas O-Methyl Methylphosphonofluoridate by ab Initio Calculations, Electron Diffraction Analysis, and NMR Spectroscopy

Journal of the American Chemical Society, 1995-07, Vol.117 (27), p.7180-7185

1995

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Genes, autoimmunity and pathogenesis of rheumatic heart disease

Annals of pediatric cardiology, 2011-01, Vol.4 (1), p.13-21

2011

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Reflections on the Discovery and Significance of Estrogen Receptor β

Endocrine reviews, 2005-05, Vol.26 (3), p.465-478

2005

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Functional probing of the human glucocorticoid receptor steroid-interacting surface by site-directed mutagenesis. Gln-642 plays an important role in steroid recognition and binding

The Journal of biological chemistry, 2000-06, Vol.275 (25), p.19041-19049

2000

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Synthetic and computer-assisted analysis of the structural requirements for selective, high-affinity ligand binding to diazepam-insensitive benzodiazepine receptors

Journal of medicinal chemistry, 1993-06, Vol.36 (13), p.1820-1830

1993

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Oestrogen Receptors and Selective Oestrogen Receptor Modulators: Molecular and Cellular Pharmacology

Basic & clinical pharmacology & toxicology, 2005-01, Vol.96 (1), p.15-25

2005

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Solid-Phase Synthesis of a 6-Phenylquinolin-2(1H)-one Library Directed toward Nuclear Hormone Receptors

Journal of combinatorial chemistry, 2005-07, Vol.7 (4), p.567-573

2005

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Molecular yardsticks. Rigid probes to define the spatial dimensions of the benzodiazepine receptor binding site

Journal of medicinal chemistry, 1992-10, Vol.35 (22), p.4105-4117

1992

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Cycloaddition of nitrones with allenes. An example of steric control of regiochemistry

Journal of organic chemistry, 1987-08, Vol.52 (17), p.3909-3917

1987

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Glucocorticoid Receptor Point Mutation V571M Facilitates Coactivator and Ligand Binding by Structural Rearrangement and Stabilization

Molecular endocrinology (Baltimore, Md.), 2005-08, Vol.19 (8), p.1960-1977

2005

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Regioselectivity associated with the 1,3-dipolar cycloaddition of nitrones with electron-deficient dipolarophiles

Journal of organic chemistry, 1984-01, Vol.49 (2), p.276-281

1984

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Mouse Estrogen Receptor β Isoforms Exhibit Differences in Ligand Selectivity and Coactivator Recruitment

Biochemistry (Easton), 2005-06, Vol.44 (22), p.7936-7944

2005

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Thyroid Receptor Ligands. 3. Design and Synthesis of 3,5-Dihalo-4-alkoxyphenylalkanoic Acids as Indirect Antagonists of the Thyroid Hormone Receptor

Journal of medicinal chemistry, 2005-05, Vol.48 (9), p.3114-3117

2005

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New synthesis of .beta.-lactams based on nitrone cycloaddition to nitroalkenes

Journal of organic chemistry, 1984-01, Vol.49 (2), p.282-288

1984

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Thyroid receptor ligands. Part 4: 4′-amido bioisosteric ligands selective for the thyroid hormone receptor beta

Bioorganic & medicinal chemistry letters, 2006-02, Vol.16 (4), p.884-886

2006

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Thyroid receptor ligands. Part 5: Novel bicyclic agonist ligands selective for the thyroid hormone receptor β

Bioorganic & medicinal chemistry letters, 2006-03, Vol.16 (5), p.1240-1244

2006

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No evidence for association of the TP53 12139 and the BAX−248 polymorphisms with endemic pemphigus foliaceus (fogo selvagem)

International Journal of Immunogenetics, 2006-04, Vol.33 (2), p.141-144

2006

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Modeling of the Bryostatins to the Phorbol Ester Pharmacophore on Protein Kinase C

Analysis of the Phorbol Ester Pharmacophore on Protein Kinase C as a Guide to the Rational Design of New Classes of Analogs

Development of a comprehensive pharmacophore model for the benzodiazepine receptor

Synthesis of benzo-fused benzodiazepines employed as probes of the agonist pharmacophore of benzodiazepine receptors

Synthetic and computer-assisted analyses of the pharmacophore for the benzodiazepine receptor inverse agonist site

Development of subtype-selective oestrogen receptor-based therapeutics

Predictive binding of .beta.-carboline inverse agonists and antagonists via the CoMFA/GOLPE approach

Synthetic and computer assisted analysis of the pharmacophore for agonists at benzodiazepine receptors

Determination of the Structure and Chiroptical Properties of the Parent Nerve Gas O-Methyl Methylphosphonofluoridate by ab Initio Calculations, Electron Diffraction Analysis, and NMR Spectroscopy

Genes, autoimmunity and pathogenesis of rheumatic heart disease

Reflections on the Discovery and Significance of Estrogen Receptor β

Functional probing of the human glucocorticoid receptor steroid-interacting surface by site-directed mutagenesis. Gln-642 plays an important role in steroid recognition and binding

Synthetic and computer-assisted analysis of the structural requirements for selective, high-affinity ligand binding to diazepam-insensitive benzodiazepine receptors

Oestrogen Receptors and Selective Oestrogen Receptor Modulators: Molecular and Cellular Pharmacology

Solid-Phase Synthesis of a 6-Phenylquinolin-2(1H)-one Library Directed toward Nuclear Hormone Receptors

Molecular yardsticks. Rigid probes to define the spatial dimensions of the benzodiazepine receptor binding site

Cycloaddition of nitrones with allenes. An example of steric control of regiochemistry

Glucocorticoid Receptor Point Mutation V571M Facilitates Coactivator and Ligand Binding by Structural Rearrangement and Stabilization

Regioselectivity associated with the 1,3-dipolar cycloaddition of nitrones with electron-deficient dipolarophiles

Mouse Estrogen Receptor β Isoforms Exhibit Differences in Ligand Selectivity and Coactivator Recruitment

Thyroid Receptor Ligands. 3. Design and Synthesis of 3,5-Dihalo-4-alkoxyphenylalkanoic Acids as Indirect Antagonists of the Thyroid Hormone Receptor

New synthesis of .beta.-lactams based on nitrone cycloaddition to nitroalkenes

Thyroid receptor ligands. Part 4: 4′-amido bioisosteric ligands selective for the thyroid hormone receptor beta

Thyroid receptor ligands. Part 5: Novel bicyclic agonist ligands selective for the thyroid hormone receptor β

No evidence for association of the TP53 12139 and the BAX−248 polymorphisms with endemic pemphigus foliaceus (fogo selvagem)

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