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CA-170 - A Potent Small-Molecule PD-L1 Inhibitor or Not?

Molecules (Basel, Switzerland), 2019-08, Vol.24 (15), p.2804

2019

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Bioactive Macrocyclic Inhibitors of the PD‐1/PD‐L1 Immune Checkpoint

Angewandte Chemie International Edition, 2017-10, Vol.56 (44), p.13732-13735

International ed. in English, 2017

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Human and mouse PD-L1: similar molecular structure, but different druggability profiles

iScience, 2021-01, Vol.24 (1), p.101960-101960, Article 101960

2021

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PD-L1 Inhibitors: Different Classes, Activities, and Mechanisms of Action

International journal of molecular sciences, 2021-10, Vol.22 (21), p.11797

2021

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Structural and biological characterization of pAC65, a macrocyclic peptide that blocks PD-L1 with equivalent potency to the FDA-approved antibodies

Molecular cancer, 2023-09, Vol.22 (1), p.1-150, Article 150

2023

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Biphenyl Ether Analogs Containing Pomalidomide as Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction

Molecules (Basel, Switzerland), 2022-05, Vol.27 (11), p.3454

2022

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Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells

Oncotarget, 2017-09, Vol.8 (42), p.72167-72181

2017

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Di-bromo-Based Small-Molecule Inhibitors of the PD-1/PD-L1 Immune Checkpoint

Journal of medicinal chemistry, 2020-10, Vol.63 (19), p.11271-11285

2020

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Helping the Released Guardian: Drug Combinations for Supporting the Anticancer Activity of HDM2 (MDM2) Antagonists

Cancers, 2019-07, Vol.11 (7), p.1014

2019

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Prolonged Idasanutlin (RG7388) Treatment Leads to the Generation of p53-Mutated Cells

Cancers, 2018-10, Vol.10 (11), p.396

2018

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Abstract A020: The highly predictive 3D Cell Co-Culture Model for Immunotherapy studies

Cancer immunology research, 2024-10, Vol.12 (10_Supplement), p.A020-A020

2024

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Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein–Protein Interaction

Journal of medicinal chemistry, 2021-08, Vol.64 (15), p.11614-11636

2021

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Macrocyclic Peptide Inhibitor of PD‐1/PD‐L1 Immune Checkpoint

Advanced therapeutics, 2021-02, Vol.4 (2), p.n/a

2021

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Therapeutic Responses to Two New SN-38 Derivatives in Colorectal Cancer Patient-Derived Xenografts and Respective 3D In Vitro Cultures

Anticancer research, 2024-10, Vol.44 (10), p.4219-4224

2024

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Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for m‑Terphenyl Derivatives

ACS medicinal chemistry letters, 2024-01, Vol.15 (1), p.36-44

2024

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Abstract B093: The evaluation of the gene expression profile of pancreatic ductal adenocarcinomas (PDACs) in 3D cell culture vs in vivo and development of new 3D PDACs' models for an evaluation of anti-cancer drug testing

Cancer research (Chicago, Ill.), 2024-09, Vol.84 (17_Supplement_2), p.B093-B093

2024

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Design, Synthesis, and Biological Evaluation of 2‑Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors

Journal of medicinal chemistry, 2023-07, Vol.66 (14), p.9577-9591

2023

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Bioactive Macrocyclic Inhibitors of the PD‐1/PD‐L1 Immune Checkpoint

Angewandte Chemie, 2017-10, Vol.129 (44), p.13920-13923

2017

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Identification and characteristics of biological agents in work environment of medical emergency services in selected ambulances

International journal of occupational medicine and environmental health, 2017-07, Vol.30 (4), p.617-627

2017

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Antiviral activity of novel oseltamivir derivatives against some influenza virus strains

Acta biochimica Polonica, 2014-01, Vol.61 (3), p.509

2014

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Microbiological analysis of bioaerosols collected from Hospital Emergency Departments and ambulances

Annals of Agricultural and Environmental Medicine, 2018-06, Vol.25 (2), p.274-279

2018

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Surveillance of hantaviruses in Poland: a study of animal reservoirs and human hantavirus disease in Subcarpathia

Vector borne and zoonotic diseases (Larchmont, N.Y.), 2014-07, Vol.14 (7), p.514-522

2014

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Research on prevention and treatment of hemorrhagic fevers

Annals of Agricultural and Environmental Medicine, 2012-01, Vol.19 (2), p.165-171

2012

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Research on substances with activity against orthopoxviruses

Annals of Agricultural and Environmental Medicine, 2013, Vol.20 (1), p.1-7

2013

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Diversity of influenza-like illness etiology in Polish Armed Forces in influenza epidemic season

Acta biochimica Polonica, 2014-01, Vol.61 (3), p.489

2014

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CA-170 - A Potent Small-Molecule PD-L1 Inhibitor or Not?

Bioactive Macrocyclic Inhibitors of the PD‐1/PD‐L1 Immune Checkpoint

Human and mouse PD-L1: similar molecular structure, but different druggability profiles

PD-L1 Inhibitors: Different Classes, Activities, and Mechanisms of Action

Structural and biological characterization of pAC65, a macrocyclic peptide that blocks PD-L1 with equivalent potency to the FDA-approved antibodies

Biphenyl Ether Analogs Containing Pomalidomide as Small-Molecule Inhibitors of the Programmed Cell Death-1/Programmed Cell Death-Ligand 1 Interaction

Small-molecule inhibitors of PD-1/PD-L1 immune checkpoint alleviate the PD-L1-induced exhaustion of T-cells

Di-bromo-Based Small-Molecule Inhibitors of the PD-1/PD-L1 Immune Checkpoint

Helping the Released Guardian: Drug Combinations for Supporting the Anticancer Activity of HDM2 (MDM2) Antagonists

Prolonged Idasanutlin (RG7388) Treatment Leads to the Generation of p53-Mutated Cells

Abstract A020: The highly predictive 3D Cell Co-Culture Model for Immunotherapy studies

Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein–Protein Interaction

Macrocyclic Peptide Inhibitor of PD‐1/PD‐L1 Immune Checkpoint

Therapeutic Responses to Two New SN-38 Derivatives in Colorectal Cancer Patient-Derived Xenografts and Respective 3D In Vitro Cultures

Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for m‑Terphenyl Derivatives

Abstract B093: The evaluation of the gene expression profile of pancreatic ductal adenocarcinomas (PDACs) in 3D cell culture vs in vivo and development of new 3D PDACs' models for an evaluation of anti-cancer drug testing

Design, Synthesis, and Biological Evaluation of 2‑Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors

Bioactive Macrocyclic Inhibitors of the PD‐1/PD‐L1 Immune Checkpoint

Identification and characteristics of biological agents in work environment of medical emergency services in selected ambulances

Antiviral activity of novel oseltamivir derivatives against some influenza virus strains

Microbiological analysis of bioaerosols collected from Hospital Emergency Departments and ambulances

Surveillance of hantaviruses in Poland: a study of animal reservoirs and human hantavirus disease in Subcarpathia

Research on prevention and treatment of hemorrhagic fevers

Research on substances with activity against orthopoxviruses

Diversity of influenza-like illness etiology in Polish Armed Forces in influenza epidemic season

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