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The relaxin receptor as a therapeutic target – perspectives from evolution and drug targeting

Pharmacology & therapeutics (Oxford), 2018-07, Vol.187, p.114-132

2018

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Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis

Kidney international, 2014-07, Vol.86 (1), p.75-85

2014

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Investigation of interactions between TLR2, MyD88 and TIRAP by bioluminescence resonance energy transfer is hampered by artefacts of protein overexpression

PloS one, 2018-08, Vol.13 (8), p.e0202408-e0202408

2018

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Probing the correlation between ligand efficacy and conformational diversity at the α1A-adrenoreceptor reveals allosteric coupling of its microswitches

The Journal of biological chemistry, 2020-05, Vol.295 (21), p.7404-7417

2020

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ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

Scientific reports, 2017-06, Vol.7 (1), p.2968-14, Article 2968

2017

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A Real-Time, Plate-Based BRET Assay for Detection of cGMP in Primary Cells

International journal of molecular sciences, 2022-02, Vol.23 (3), p.1908

2022

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A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

Chemical science (Cambridge), 2016-01, Vol.7 (6), p.3805-3819

2016

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Signal transduction pathways activated by insulin‐like peptide 5 at the relaxin family peptide RXFP4 receptor

British journal of pharmacology, 2017-05, Vol.174 (10), p.1077-1089

2017

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BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β2-adrenoceptors without causing classical receptor desensitization

American journal of physiology. Regulatory, integrative and comparative physiology, 2019-05, Vol.316 (5), p.R666-R677

2019

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Demonstration of improvements to the bioluminescence resonance energy transfer (BRET) technology for the monitoring of G protein-coupled receptors in live cells

Journal of biomolecular screening, 2008-10, Vol.13 (9), p.888-898

2008

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Cathepsin S Causes Inflammatory Pain via Biased Agonism of PAR2 and TRPV4

The Journal of biological chemistry, 2014-09, Vol.289 (39), p.27215-27234

2014

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Single chain peptide agonists of relaxin receptors

Molecular and cellular endocrinology, 2019-05, Vol.487, p.34-39

2019

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Understanding relaxin signalling at the cellular level

Molecular and cellular endocrinology, 2019-05, Vol.487, p.24-33

2019

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Two-Component Systems of Corynebacterium glutamicum: Deletion Analysis and Involvement of the PhoS-PhoR System in the Phosphate Starvation Response

Journal of Bacteriology, 2006-01, Vol.188 (2), p.724-732

2006

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Engineering a long acting, non-biased relaxin agonist using Protein-in-Protein technology

Biochemical pharmacology, 2024-09, Vol.227, p.116401, Article 116401

2024

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AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis

Journal of the American Society of Nephrology, 2019-11, Vol.30 (11), p.2191-2207

2019

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Noncovalent Peptide Stapling Using Alpha-Methyl‑l‑Phenylalanine for α‑Helical Peptidomimetics

Journal of the American Chemical Society, 2023-09, Vol.145 (37), p.20242-20247

2023

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GPR55 regulates the responsiveness to, but does not dimerise with, α1A-adrenoceptors

Biochemical pharmacology, 2021-06, Vol.188, p.114560-114560, Article 114560

2021

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An apically located hybrid guanylate cyclase–ATPase is critical for the initiation of Ca2+ signaling and motility in Toxoplasma gondii

The Journal of biological chemistry, 2019-05, Vol.294 (22), p.8959-8972

2019

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The Bile Acid Receptor TGR5 Does Not Interact with β-Arrestins or Traffic to Endosomes but Transmits Sustained Signals from Plasma Membrane Rafts

The Journal of biological chemistry, 2013-08, Vol.288 (32), p.22942-22960

2013

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A manually curated compendium of expression profiles for the microbial cell factory Corynebacterium glutamicum

Scientific data, 2022-10, Vol.9 (1), p.594-594, Article 594

2022

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Structure–function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins

The Journal of biological chemistry, 2017-09, Vol.292 (36), p.15143-15158

2017

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Minimization of Human Relaxin-3 Leading to High-Affinity Analogues with Increased Selectivity for Relaxin-Family Peptide 3 Receptor (RXFP3) over RXFP1

Journal of medicinal chemistry, 2012-02, Vol.55 (4), p.1671-1681

2012

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Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist

Journal of medicinal chemistry, 2016-03, Vol.59 (5), p.2118-2125

2016

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BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via beta(2)-adrenoceptors without causing classical receptor desensitization

American journal of physiology. Regulatory, integrative and comparative physiology, 2019, Vol.316 (5), p.R666

2019

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The relaxin receptor as a therapeutic target – perspectives from evolution and drug targeting

Relaxin requires the angiotensin II type 2 receptor to abrogate renal interstitial fibrosis

Investigation of interactions between TLR2, MyD88 and TIRAP by bioluminescence resonance energy transfer is hampered by artefacts of protein overexpression

Probing the correlation between ligand efficacy and conformational diversity at the α1A-adrenoreceptor reveals allosteric coupling of its microswitches

ML290 is a biased allosteric agonist at the relaxin receptor RXFP1

A Real-Time, Plate-Based BRET Assay for Detection of cGMP in Primary Cells

A single-chain derivative of the relaxin hormone is a functionally selective agonist of the G protein-coupled receptor, RXFP1

Signal transduction pathways activated by insulin‐like peptide 5 at the relaxin family peptide RXFP4 receptor

BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via β2-adrenoceptors without causing classical receptor desensitization

Demonstration of improvements to the bioluminescence resonance energy transfer (BRET) technology for the monitoring of G protein-coupled receptors in live cells

Cathepsin S Causes Inflammatory Pain via Biased Agonism of PAR2 and TRPV4

Single chain peptide agonists of relaxin receptors

Understanding relaxin signalling at the cellular level

Two-Component Systems of Corynebacterium glutamicum: Deletion Analysis and Involvement of the PhoS-PhoR System in the Phosphate Starvation Response

Engineering a long acting, non-biased relaxin agonist using Protein-in-Protein technology

AT1R-AT2R-RXFP1 Functional Crosstalk in Myofibroblasts: Impact on the Therapeutic Targeting of Renal and Cardiac Fibrosis

Noncovalent Peptide Stapling Using Alpha-Methyl‑l‑Phenylalanine for α‑Helical Peptidomimetics

GPR55 regulates the responsiveness to, but does not dimerise with, α1A-adrenoceptors

An apically located hybrid guanylate cyclase–ATPase is critical for the initiation of Ca2+ signaling and motility in Toxoplasma gondii

The Bile Acid Receptor TGR5 Does Not Interact with β-Arrestins or Traffic to Endosomes but Transmits Sustained Signals from Plasma Membrane Rafts

A manually curated compendium of expression profiles for the microbial cell factory Corynebacterium glutamicum

Structure–function analyses of a pertussis-like toxin from pathogenic Escherichia coli reveal a distinct mechanism of inhibition of trimeric G-proteins

Minimization of Human Relaxin-3 Leading to High-Affinity Analogues with Increased Selectivity for Relaxin-Family Peptide 3 Receptor (RXFP3) over RXFP1

Engineering of a Novel Simplified Human Insulin-Like Peptide 5 Agonist

BRL37344 stimulates GLUT4 translocation and glucose uptake in skeletal muscle via beta(2)-adrenoceptors without causing classical receptor desensitization

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