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Pharmacological Analysis of Cyclooxygenase-1 in Inflammation

Proceedings of the National Academy of Sciences - PNAS, 1998-10, Vol.95 (22), p.13313-13318

1998

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N-[[(5-Methyl-3-phenylisoxazol-4-yl)- phenyl]sulfonyl]propanamide, Sodium Salt, Parecoxib Sodium: A Potent and Selective Inhibitor of COX-2 for Parenteral Administration

Journal of medicinal chemistry, 2000-05, Vol.43 (9), p.1661-1663

2000

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Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity

The Journal of pharmacology and experimental therapeutics, 2005-03, Vol.312 (3), p.1206-1212

2005

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1,2-Diarylimidazoles as Potent, Cyclooxygenase-2 Selective, and Orally Active Antiinflammatory Agents

Journal of medicinal chemistry, 1997-05, Vol.40 (11), p.1634-1647

1997

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4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2

Journal of medicinal chemistry, 2000-03, Vol.43 (5), p.775-777

2000

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Kinetic basis for selective inhibition of cyclo-oxygenases

Biochemical journal, 1999-05, Vol.339 ( Pt 3) (3), p.607-614

1999

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A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and â2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors

The Journal of biological chemistry, 1996-06, Vol.271 (26), p.15810-15814

1996

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Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors

Bioorganic & medicinal chemistry letters, 1999-04, Vol.9 (8), p.1171-1174

1999

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Selective Cyclooxygenase-2 Inhibitors: Heteroaryl Modified 1,2-Diarylimidazoles Are Potent, Orally Active Antiinflammatory Agents

Journal of medicinal chemistry, 2000-08, Vol.43 (16), p.3168-3185

2000

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A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors

Biochemical journal, 2001-08, Vol.357 (Pt 3), p.709-718

2001

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Diarylspiro[2.4]heptenes as Orally Active, Highly Selective Cyclooxygenase-2 Inhibitors: Synthesis and Structure−Activity Relationships

Journal of medicinal chemistry, 1996-01, Vol.39 (1), p.253-266

1996

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1,2-Diarylpyrroles as Potent and Selective Inhibitors of Cyclooxygenase-2

Journal of medicinal chemistry, 1997-05, Vol.40 (11), p.1619-1633

1997

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Novel Terphenyls as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents

Journal of medicinal chemistry, 1996-04, Vol.39 (9), p.1846-1856

1996

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Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

Bioorganic & medicinal chemistry letters, 1999-04, Vol.9 (8), p.1167-1170

1999

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Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Journal of medicinal chemistry, 1997-04, Vol.40 (9), p.1347-1365

1997

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4,5-Diaryloxazole inhibitors of cyclooxygenase-2 (COX-2)

Medicinal research reviews, 1999-05, Vol.19 (3), p.199-208

1999

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A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors

Biochemical journal, 2001-08, Vol.357 (3), p.709-718

2001

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Characterization of the Recombinant IKK1/IKK2 Heterodimer

The Journal of biological chemistry, 2000-08, Vol.275 (34), p.25883-25891

2000

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1,2-Diarylcyclopentenes as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents

Journal of medicinal chemistry, 1995-10, Vol.38 (22), p.4570-4578

1995

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Characterization of the recombinant IKK1/IKK2 heterodimer. Mechanisms regulating kinase activity

The Journal of biological chemistry, 2000-08, Vol.275 (34), p.25883-25891

2000

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Selective Cyclooxygenase Inhibitors: Novel 1,2-Diarylcyclopentenes Are Potent and Orally Active COX-2 Inhibitors

Journal of medicinal chemistry, 1994-11, Vol.37 (23), p.3878-3881

1994

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Conformationally restricted 1,5-diarylpyrazoles are selective COX-2 inhibitors

Bioorganic & medicinal chemistry letters, 1996-12, Vol.6 (23), p.2827-2830

1996

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Diaryl indenes and benzofurans: Novel classes of potent and selective cyclooxygenase-2 inhibitors

Bioorganic & medicinal chemistry letters, 1995-10, Vol.5 (20), p.2377-2380

1995

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Cloning, expression, and selective inhibition of canine cyclooxygenase-1 and cyclooxygenase-2

Veterinary therapeutics, 2002, Vol.3 (3), p.270

2002

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Kinetic basis for selective inhibition of cyclo-oxygenases

Biochemical journal, 1999-05, Vol.339 (3), p.607-614

1999

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Pharmacological Analysis of Cyclooxygenase-1 in Inflammation

N-[[(5-Methyl-3-phenylisoxazol-4-yl)- phenyl]sulfonyl]propanamide, Sodium Salt, Parecoxib Sodium: A Potent and Selective Inhibitor of COX-2 for Parenteral Administration

Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity

1,2-Diarylimidazoles as Potent, Cyclooxygenase-2 Selective, and Orally Active Antiinflammatory Agents

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, Valdecoxib: A Potent and Selective Inhibitor of COX-2

Kinetic basis for selective inhibition of cyclo-oxygenases

A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and â2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors

Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors

Selective Cyclooxygenase-2 Inhibitors: Heteroaryl Modified 1,2-Diarylimidazoles Are Potent, Orally Active Antiinflammatory Agents

A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors

Diarylspiro[2.4]heptenes as Orally Active, Highly Selective Cyclooxygenase-2 Inhibitors: Synthesis and Structure−Activity Relationships

1,2-Diarylpyrroles as Potent and Selective Inhibitors of Cyclooxygenase-2

Novel Terphenyls as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents

Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors: Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1H-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

4,5-Diaryloxazole inhibitors of cyclooxygenase-2 (COX-2)

A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors

Characterization of the Recombinant IKK1/IKK2 Heterodimer

1,2-Diarylcyclopentenes as Selective Cyclooxygenase-2 Inhibitors and Orally Active Anti-inflammatory Agents

Characterization of the recombinant IKK1/IKK2 heterodimer. Mechanisms regulating kinase activity

Selective Cyclooxygenase Inhibitors: Novel 1,2-Diarylcyclopentenes Are Potent and Orally Active COX-2 Inhibitors

Conformationally restricted 1,5-diarylpyrazoles are selective COX-2 inhibitors

Diaryl indenes and benzofurans: Novel classes of potent and selective cyclooxygenase-2 inhibitors

Cloning, expression, and selective inhibition of canine cyclooxygenase-1 and cyclooxygenase-2

Kinetic basis for selective inhibition of cyclo-oxygenases

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