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Hepatic Activation and Inactivation of Clinically-relevant Vitamin D Analogs and Prodrugs

Anticancer research, 2006-07, Vol.26 (4A), p.2589-2596

2006

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1,24(S)-Dihydroxyvitamin D2, an Endogenous Vitamin D2 Metabolite, Inhibits Growth of Breast Cancer Cells and Tumors

Anticancer research, 2005-01, Vol.25 (1A), p.235-241

2005

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Differential effects of oral doxercalciferol (Hectorol) or paricalcitol (Zemplar) in the Cyp27b1-null mouse model of uremia

Nephron, 2011-10, Vol.119 (3), p.e67-e74

2011

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The vitamin D prodrugs 1α(OH)D2, 1α(OH)D3 and BCI-210 suppress PTH secretion by bovine parathyroid cells

Nephrology, dialysis, transplantation, 2006-03, Vol.21 (3), p.644-650

2006

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Insights into Vitamin D metabolism using cyp24 over-expression and knockout systems in conjunction with liquid chromatography/mass spectrometry (LC/MS)

Journal of steroid biochemistry and molecular biology, 2004-05, Vol.89 (1-5), p.149-153

2004

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2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity

Annual review of pharmacology and toxicology, 1982, Vol.22 (1), p.517-554

1982

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Pharmacokinetics of doxercalciferol, a new vitamin D analogue that lowers parathyroid hormone

Nephrology, dialysis, transplantation, 2003-04, Vol.18 (4), p.750-758

2003

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Tissue distribution and activity studies of 1,24-dihydroxyvitamin D2, a metabolite of vitamin D2 with low calcemic activity in vivo

Biochemical pharmacology, 2004-10, Vol.68 (7), p.1289-1296

2004

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A Stereospecific Synthesis of 24(S)-Hydroxyvitamin D2, a Prodrug for 1α,24(S)-Dihydroxyvitamin D2

Organic process research & development, 2002-05, Vol.6 (3), p.246-255

2002

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Evidence for the activation of 1α-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: Delineation of pathways involving 1α,24-dihydroxyvitamin D2 and 1α,25-dihydroxyvitamin D2

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2006-02, Vol.1761 (2), p.221-234

2006

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Evidence for the activation of 1α-hydroxyvitamin D 2 by 25-hydroxyvitamin D-24-hydroxylase: Delineation of pathways involving 1α,24-dihydroxyvitamin D 2 and 1α,25-dihydroxyvitamin D 2

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2006-02, Vol.1761 (2), p.221-234

2006

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Effective suppression of parathyroid hormone by 1α-hydroxy-vitamin D2 in hemodialysis patients with moderate to severe secondary hyperparathyroidism

Kidney international, 1997-01, Vol.51 (1), p.317-323

1997

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The level of c-fgr RNA is increased by EBNA-2, an Epstein-Barr virus gene required for B-cell immortalization

Journal of Virology, 1990-06, Vol.64 (6), p.2530-2536

KNUTSON, J. C

1990

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The vitamin D prodrugs 1[alpha](OH)D2, 1[alpha](OH)D3 and BCI-210 suppress PTH secretion by bovine parathyroid cells

Nephrology, dialysis, transplantation, 2006-03, Vol.21 (3), p.644

2006

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The vitamin D prodrugs 1alpha(OH)D2, 1alpha(OH)D3 and BCI-210 suppress PTH secretion by bovine parathyroid cells

Nephrology, dialysis, transplantation, 2006-03, Vol.21 (3), p.644-650

2006

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Tissue distribution and activity studies of 1,24-dihydroxyvitamin D 2, a metabolite of vitamin D 2 with low calcemic activity in vivo

Biochemical pharmacology, 2004-10, Vol.68 (7), p.1289-1296

2004

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Unique 24-hydroxylated metabolites represent a significant pathway of metabolism of vitamin D2 in humans: 24-hydroxyvitamin D2 and 1,24-dihydroxyvitamin D2 detectable in human serum

The journal of clinical endocrinology and metabolism, 1998-06, Vol.83 (6), p.2156-2166

1998

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25-Hydroxyvitamin D3-24-hydroxylase. Subcellular location and properties

Biochemistry (Easton), 1974-03, Vol.13 (7), p.1543-1548

1974

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Pharmacokinetics and systemic effect on calcium homeostasis of 1α,24-dihydroxyvitamin D2 in rats : Comparison with 1α,25-dihydroxyvitamin D2, calcitriol, and calcipotriol

Biochemical pharmacology, 1997-03, Vol.53 (6), p.829-837

1997

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Pharmacokinetics and systemic effect on calcium homeostasis of 1α,24-dihydroxyvitamin D 2 in rats comparison with 1α,25-Dihydroxyvitamin d 2, calcitriol, and calcipotriol

Biochemical pharmacology, 1997-03, Vol.53 (6), p.829-837

1997

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Use of vitamin D 4 analogs to investigate differences in hepatic and target cell metabolism of vitamins D 2 and D 3

Biochimica et biophysica acta. Molecular and cell biology of lipids, 2002-07, Vol.1583 (2), p.151-166

2002

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Mitochondrial Cytochrome P450

The Journal of biological chemistry, 1974-05, Vol.249 (10), p.3026-3033

1974

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Electroporation: Parameters affecting transfer of DNA into mammalian cells

Analytical biochemistry, 1987-07, Vol.164 (1), p.44-52

1987

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Effects of increasing doses of 1α‐hydroxyvitamin D2 on calcium homeostasis in postmenopausal osteopenic women

Journal of bone and mineral research, 1994-05, Vol.9 (5), p.607-614

1994

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A Stereospecific Synthesis of 24( S )-Hydroxyvitamin D 2 , a Prodrug for 1α,24( S )-Dihydroxyvitamin D 2

Organic process research & development, 2002-05, Vol.6 (3), p.246-255

2002

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Hepatic Activation and Inactivation of Clinically-relevant Vitamin D Analogs and Prodrugs

1,24(S)-Dihydroxyvitamin D2, an Endogenous Vitamin D2 Metabolite, Inhibits Growth of Breast Cancer Cells and Tumors

Differential effects of oral doxercalciferol (Hectorol) or paricalcitol (Zemplar) in the Cyp27b1-null mouse model of uremia

The vitamin D prodrugs 1α(OH)D2, 1α(OH)D3 and BCI-210 suppress PTH secretion by bovine parathyroid cells

Insights into Vitamin D metabolism using cyp24 over-expression and knockout systems in conjunction with liquid chromatography/mass spectrometry (LC/MS)

2,3,7,8-tetrachlorodibenzo-p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity

Pharmacokinetics of doxercalciferol, a new vitamin D analogue that lowers parathyroid hormone

Tissue distribution and activity studies of 1,24-dihydroxyvitamin D2, a metabolite of vitamin D2 with low calcemic activity in vivo

A Stereospecific Synthesis of 24(S)-Hydroxyvitamin D2, a Prodrug for 1α,24(S)-Dihydroxyvitamin D2

Evidence for the activation of 1α-hydroxyvitamin D2 by 25-hydroxyvitamin D-24-hydroxylase: Delineation of pathways involving 1α,24-dihydroxyvitamin D2 and 1α,25-dihydroxyvitamin D2

Evidence for the activation of 1α-hydroxyvitamin D 2 by 25-hydroxyvitamin D-24-hydroxylase: Delineation of pathways involving 1α,24-dihydroxyvitamin D 2 and 1α,25-dihydroxyvitamin D 2

Effective suppression of parathyroid hormone by 1α-hydroxy-vitamin D2 in hemodialysis patients with moderate to severe secondary hyperparathyroidism

The level of c-fgr RNA is increased by EBNA-2, an Epstein-Barr virus gene required for B-cell immortalization

The vitamin D prodrugs 1[alpha](OH)D2, 1[alpha](OH)D3 and BCI-210 suppress PTH secretion by bovine parathyroid cells

The vitamin D prodrugs 1alpha(OH)D2, 1alpha(OH)D3 and BCI-210 suppress PTH secretion by bovine parathyroid cells

Tissue distribution and activity studies of 1,24-dihydroxyvitamin D 2, a metabolite of vitamin D 2 with low calcemic activity in vivo

Unique 24-hydroxylated metabolites represent a significant pathway of metabolism of vitamin D2 in humans: 24-hydroxyvitamin D2 and 1,24-dihydroxyvitamin D2 detectable in human serum

25-Hydroxyvitamin D3-24-hydroxylase. Subcellular location and properties

Pharmacokinetics and systemic effect on calcium homeostasis of 1α,24-dihydroxyvitamin D2 in rats : Comparison with 1α,25-dihydroxyvitamin D2, calcitriol, and calcipotriol

Pharmacokinetics and systemic effect on calcium homeostasis of 1α,24-dihydroxyvitamin D 2 in rats comparison with 1α,25-Dihydroxyvitamin d 2, calcitriol, and calcipotriol

Use of vitamin D 4 analogs to investigate differences in hepatic and target cell metabolism of vitamins D 2 and D 3

Mitochondrial Cytochrome P450

Electroporation: Parameters affecting transfer of DNA into mammalian cells

Effects of increasing doses of 1α‐hydroxyvitamin D2 on calcium homeostasis in postmenopausal osteopenic women

A Stereospecific Synthesis of 24( S )-Hydroxyvitamin D 2 , a Prodrug for 1α,24( S )-Dihydroxyvitamin D 2

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