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Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor

American journal of physiology: Gastrointestinal and liver physiology, 2011-06, Vol.300 (6), p.G929-G938

2011

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N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis

The Journal of immunology (1950), 2011-04, Vol.186 (7), p.4396-4404

2011

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Substrate Specificity and Kinetic Studies of PADs 1, 3, and 4 Identify Potent and Selective Inhibitors of Protein Arginine Deiminase 3

Biochemistry (Easton), 2010-06, Vol.49 (23), p.4852-4863

2010

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Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps

Arthritis & rheumatology (Hoboken, N.J.), 2012-04, Vol.64 (4), p.982-992

2012

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Mechanistic Studies of Protein Arginine Deiminase 2: Evidence for a Substrate-Assisted Mechanism

Biochemistry (Easton), 2014-07, Vol.53 (27), p.4426-4433

2014

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Inhibitors and Inactivators of Protein Arginine Deiminase 4: Functional and Structural Characterization

Biochemistry (Easton), 2006-10, Vol.45 (39), p.11727-11736

2006

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A fluopol-ABPP HTS assay to identify PAD inhibitors

Chemical communications (Cambridge, England), 2010-10, Vol.46 (38), p.7175

2010

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A Fluoroacetamidine-Based Inactivator of Protein Arginine Deiminase 4: Design, Synthesis, and in Vitro and in Vivo Evaluation

Journal of the American Chemical Society, 2006-02, Vol.128 (4), p.1092-1093

2006

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Activity-Based Protein Profiling Reagents for Protein Arginine Deiminase 4 (PAD4): Synthesis and in vitro Evaluation of a Fluorescently Labeled Probe

Journal of the American Chemical Society, 2006-11, Vol.128 (45), p.14468-14469

2006

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A peptoid-based inhibitor of protein arginine methyltransferase 1 (PRMT1) induces apoptosis and autophagy in cancer cells

The Journal of biological chemistry, 2022-08, Vol.298 (8), p.102205, Article 102205

2022

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The development and characterization of a chemical probe targeting PRMT1 over PRMT5

Bioorganic & medicinal chemistry, 2019-01, Vol.27 (1), p.224-229

2019

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Histone H4-based peptoids are inhibitors of protein arginine methyltransferase 1 (PRMT1)

Biochemical journal, 2020-08, Vol.477 (16), p.2971-2980

2020

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Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism

Biochemistry (Easton), 2007-06, Vol.46 (22), p.6578-6587

2007

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Mechanistic studies of the agmatine deiminase from Listeria monocytogenes

Biochemical journal, 2016-06, Vol.473 (11), p.1553-1561

2016

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Profiling Protein Arginine Deiminase 4 (PAD4): A novel screen to identify PAD4 inhibitors

Bioorganic & medicinal chemistry, 2008-01, Vol.16 (2), p.739-745

2008

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The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors

Journal of medicinal chemistry, 2011-10, Vol.54 (19), p.6919

2011

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Design, synthesis, and in vitro evaluation of an activity-based protein profiling (ABPP) probe targeting agmatine deiminases

Bioorganic & medicinal chemistry, 2014-09, Vol.22 (17), p.4602-4608

2014

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Development of a Plate-Based Screening Assay to Investigate the Substrate Specificity of the PRMT Family of Enzymes

ACS combinatorial science, 2015-09, Vol.17 (9), p.500-505

2015

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The Development of N-α-(2-Carboxyl)benzoyl-N 5-(2-fluoro-1-iminoethyl)-l-ornithine Amide (o-F-amidine) and N-α-(2-Carboxyl)benzoyl-N 5-(2-chloro-1-iminoethyl)-l-ornithine Amide (o-Cl-amidine) As Second Generation Protein Arginine Deiminase (PAD) Inhibitors

Journal of medicinal chemistry, 2011-10, Vol.54 (19), p.6919-6935

2011

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Two Distinct Cyclodipeptide Synthases from a Marine Actinomycete Catalyze Biosynthesis of the Same Diketopiperazine Natural Product

ACS synthetic biology, 2016-07, Vol.5 (7), p.547-553

2016

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A fluopol-ABPP HTS assay to identify PAD inhibitors

Chemical communications (Cambridge, England), 2010-10, Vol.46 (38), p.7175-7177

2010

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Development of a clickable activity-based protein profiling (ABPP) probe for agmatine deiminases

Bioorganic & medicinal chemistry, 2015-05, Vol.23 (9), p.2159-2167

2015

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Haloacetamidine-Based Inactivators of Protein Arginine Deiminase 4 (PAD4): Evidence that General Acid Catalysis Promotes Efficient Inactivation

Chembiochem : a European journal of chemical biology, 2010-01, Vol.11 (2), p.161-165

2010

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Probing adenylation: using a fluorescently labelled ATP probe to directly label and immunoprecipitate VopS substrates

Molecular bioSystems, 2012-06, Vol.8 (6), p.1701-1706

2012

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Post-Training Lesions of the Medial Prefrontal Cortex Interfere with Subsequent Performance of Trace Eyeblink Conditioning

The Journal of neuroscience, 2005-11, Vol.25 (46), p.10740-10746

2005

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Suppression of colitis in mice by Cl-amidine: a novel peptidylarginine deiminase inhibitor

N-α-benzoyl-N5-(2-chloro-1-iminoethyl)-L-ornithine amide, a protein arginine deiminase inhibitor, reduces the severity of murine collagen-induced arthritis

Substrate Specificity and Kinetic Studies of PADs 1, 3, and 4 Identify Potent and Selective Inhibitors of Protein Arginine Deiminase 3

Felty's syndrome autoantibodies bind to deiminated histones and neutrophil extracellular chromatin traps

Mechanistic Studies of Protein Arginine Deiminase 2: Evidence for a Substrate-Assisted Mechanism

Inhibitors and Inactivators of Protein Arginine Deiminase 4: Functional and Structural Characterization

A fluopol-ABPP HTS assay to identify PAD inhibitors

A Fluoroacetamidine-Based Inactivator of Protein Arginine Deiminase 4: Design, Synthesis, and in Vitro and in Vivo Evaluation

Activity-Based Protein Profiling Reagents for Protein Arginine Deiminase 4 (PAD4): Synthesis and in vitro Evaluation of a Fluorescently Labeled Probe

A peptoid-based inhibitor of protein arginine methyltransferase 1 (PRMT1) induces apoptosis and autophagy in cancer cells

The development and characterization of a chemical probe targeting PRMT1 over PRMT5

Histone H4-based peptoids are inhibitors of protein arginine methyltransferase 1 (PRMT1)

Protein Arginine Deiminase 4: Evidence for a Reverse Protonation Mechanism

Mechanistic studies of the agmatine deiminase from Listeria monocytogenes

Profiling Protein Arginine Deiminase 4 (PAD4): A novel screen to identify PAD4 inhibitors

The development of N-α-(2-carboxyl)benzoyl-N(5)-(2-fluoro-1-iminoethyl)-l-ornithine amide (o-F-amidine) and N-α-(2-carboxyl)benzoyl-N(5)-(2-chloro-1-iminoethyl)-l-ornithine amide (o-Cl-amidine) as second generation protein arginine deiminase (PAD) inhibitors

Design, synthesis, and in vitro evaluation of an activity-based protein profiling (ABPP) probe targeting agmatine deiminases

Development of a Plate-Based Screening Assay to Investigate the Substrate Specificity of the PRMT Family of Enzymes

The Development of N-α-(2-Carboxyl)benzoyl-N 5-(2-fluoro-1-iminoethyl)-l-ornithine Amide (o-F-amidine) and N-α-(2-Carboxyl)benzoyl-N 5-(2-chloro-1-iminoethyl)-l-ornithine Amide (o-Cl-amidine) As Second Generation Protein Arginine Deiminase (PAD) Inhibitors

Two Distinct Cyclodipeptide Synthases from a Marine Actinomycete Catalyze Biosynthesis of the Same Diketopiperazine Natural Product

A fluopol-ABPP HTS assay to identify PAD inhibitors

Development of a clickable activity-based protein profiling (ABPP) probe for agmatine deiminases

Haloacetamidine-Based Inactivators of Protein Arginine Deiminase 4 (PAD4): Evidence that General Acid Catalysis Promotes Efficient Inactivation

Probing adenylation: using a fluorescently labelled ATP probe to directly label and immunoprecipitate VopS substrates

Post-Training Lesions of the Medial Prefrontal Cortex Interfere with Subsequent Performance of Trace Eyeblink Conditioning

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