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Cationic Arginine-Rich Peptides (CARPs): A Novel Class of Neuroprotective Agents With a Multimodal Mechanism of Action

Frontiers in neurology, 2020-02, Vol.11, p.108-108

2020

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Mitochondria and neuroprotection in stroke: Cationic arginine-rich peptides (CARPs) as a novel class of mitochondria-targeted neuroprotective therapeutics

Neurobiology of disease, 2019-01, Vol.121, p.17-33

2019

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Poly-Arginine and Arginine-Rich Peptides are Neuroprotective in Stroke Models

Journal of cerebral blood flow and metabolism, 2015-06, Vol.35 (6), p.993-1004

2015

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Comparison of neuroprotective efficacy of poly-arginine R18 and R18D (D-enantiomer) peptides following permanent middle cerebral artery occlusion in the Wistar rat and in vitro toxicity studies

PloS one, 2018-03, Vol.13 (3), p.e0193884

2018

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Neuroprotective efficacy of poly-arginine R18 and NA-1 (TAT-NR2B9c) peptides following transient middle cerebral artery occlusion in the rat

Neuroscience research, 2017-01, Vol.114, p.9-15

2017

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The Neuroprotective Efficacy of Cell-Penetrating Peptides TAT, Penetratin, Arg-9, and Pep-1 in Glutamic Acid, Kainic Acid, and In Vitro Ischemia Injury Models Using Primary Cortical Neuronal Cultures

Cellular and molecular neurobiology, 2014-03, Vol.34 (2), p.173-181

2014

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Poly-arginine-18 (R18) Confers Neuroprotection through Glutamate Receptor Modulation, Intracellular Calcium Reduction, and Preservation of Mitochondrial Function

Molecules (Basel, Switzerland), 2020-06, Vol.25 (13), p.2977

2020

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Assessment of the safety of the cationic arginine-rich peptides (CARPs) poly-arginine-18 (R18 and R18D) in ex vivo models of mast cell degranulation and red blood cell hemolysis

Biochemistry and biophysics reports, 2022-09, Vol.31, p.101305-101305, Article 101305

2022

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Poly-arginine R18 and R18D (D-enantiomer) peptides reduce infarct volume and improves behavioural outcomes following perinatal hypoxic-ischaemic encephalopathy in the P7 rat

Molecular brain, 2018-02, Vol.11 (1), p.8-8, Article 8

2018

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Proteomic analysis of cortical neuronal cultures treated with poly-arginine peptide-18 (R18) and exposed to glutamic acid excitotoxicity

Molecular brain, 2019-07, Vol.12 (1), p.66-16, Article 66

2019

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Evidence that intracellular cyclophilin A and cyclophilin A/CD147 receptor-mediated ERK1/2 signalling can protect neurons against in vitro oxidative and ischemic injury

Neurobiology of disease, 2007-01, Vol.25 (1), p.54-64

2007

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Corrigendum to “Microglia are both a source and target of extracellular cyclophilin A” [Heliyon 5(9) August 2019 e02390]

Heliyon, 2023-02, Vol.9 (2), p.e12842-e12842, Article e12842

2023

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Effect of Polyarginine Peptide R18D Following a Traumatic Brain Injury in Sprague-Dawley Rats

Current therapeutic research, 2020-01, Vol.92, p.100584-100584, Article 100584

2020

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Assessment of R18, COG1410, and APP96-110 in excitotoxicity and traumatic brain injury

Translational neuroscience, 2017-01, Vol.8 (1), p.147-157

2017

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Perinatal Hypoxic-Ischemic Encephalopathy and Neuroprotective Peptide Therapies: A Case for Cationic Arginine-Rich Peptides (CARPs)

Brain sciences, 2018-08, Vol.8 (8), p.147

2018

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AP-1 inhibitory peptides are neuroprotective following acute glutamate excitotoxicity in primary cortical neuronal cultures

Journal of neurochemistry, 2010-01, Vol.112 (1), p.258-270

2010

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Microglia are both a source and target of extracellular cyclophilin A

Heliyon, 2019-09, Vol.5 (9), p.e02390-e02390, Article e02390

2019

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Neuroprotective Cationic Arginine-Rich Peptides (CARPs): An Assessment of Their Clinical Safety

Drug safety, 2020-10, Vol.43 (10), p.957-969

2020

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The effect of blood pressure (37 vs 45 mmHg) and carotid occlusion duration (8 vs 10 min) on CA1–4 neuronal damage when using isoflurane in a global cerebral ischemia rat model

Brain research bulletin, 2011-11, Vol.86 (5), p.390-394

2011

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Assessment of recombinant tissue plasminogen activator (rtPA) toxicity in cultured neural cells and subsequent treatment with poly-arginine peptide R18D

Neurochemical research, 2020-05, Vol.45 (5), p.1215-1229

2020

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Neuroprotective peptides fused to arginine-rich cell penetrating peptides: Neuroprotective mechanism likely mediated by peptide endocytic properties

Pharmacology & therapeutics (Oxford), 2015-09, Vol.153, p.36-54

2015

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Assessment of therapeutic window for poly‐arginine‐18D (R18D) in a P7 rat model of perinatal hypoxic‐ischaemic encephalopathy

Journal of neuroscience research, 2018-11, Vol.96 (11), p.1816-1826

2018

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Impact of poly-arginine peptides R18D and R18 on alteplase and tenecteplase thrombolysis in vitro, and neuroprotective stability to proteolysis

Journal of thrombosis and thrombolysis, 2022-07, Vol.54 (1), p.172-182

2022

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NCX3 knockout mice exhibit increased hippocampal CA1 and CA2 neuronal damage compared to wild-type mice following global cerebral ischemia

Experimental neurology, 2008-03, Vol.210 (1), p.268-273

2008

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The Neuroprotective Peptide Poly-Arginine-12 (R12) Reduces Cell Surface Levels of NMDA NR2B Receptor Subunit in Cortical Neurons; Investigation into the Involvement of Endocytic Mechanisms

Journal of molecular neuroscience, 2017-02, Vol.61 (2), p.235-246

2017

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Cationic Arginine-Rich Peptides (CARPs): A Novel Class of Neuroprotective Agents With a Multimodal Mechanism of Action

Mitochondria and neuroprotection in stroke: Cationic arginine-rich peptides (CARPs) as a novel class of mitochondria-targeted neuroprotective therapeutics

Poly-Arginine and Arginine-Rich Peptides are Neuroprotective in Stroke Models

Comparison of neuroprotective efficacy of poly-arginine R18 and R18D (D-enantiomer) peptides following permanent middle cerebral artery occlusion in the Wistar rat and in vitro toxicity studies

Neuroprotective efficacy of poly-arginine R18 and NA-1 (TAT-NR2B9c) peptides following transient middle cerebral artery occlusion in the rat

The Neuroprotective Efficacy of Cell-Penetrating Peptides TAT, Penetratin, Arg-9, and Pep-1 in Glutamic Acid, Kainic Acid, and In Vitro Ischemia Injury Models Using Primary Cortical Neuronal Cultures

Poly-arginine-18 (R18) Confers Neuroprotection through Glutamate Receptor Modulation, Intracellular Calcium Reduction, and Preservation of Mitochondrial Function

Assessment of the safety of the cationic arginine-rich peptides (CARPs) poly-arginine-18 (R18 and R18D) in ex vivo models of mast cell degranulation and red blood cell hemolysis

Poly-arginine R18 and R18D (D-enantiomer) peptides reduce infarct volume and improves behavioural outcomes following perinatal hypoxic-ischaemic encephalopathy in the P7 rat

Proteomic analysis of cortical neuronal cultures treated with poly-arginine peptide-18 (R18) and exposed to glutamic acid excitotoxicity

Evidence that intracellular cyclophilin A and cyclophilin A/CD147 receptor-mediated ERK1/2 signalling can protect neurons against in vitro oxidative and ischemic injury

Corrigendum to “Microglia are both a source and target of extracellular cyclophilin A” [Heliyon 5(9) August 2019 e02390]

Effect of Polyarginine Peptide R18D Following a Traumatic Brain Injury in Sprague-Dawley Rats

Assessment of R18, COG1410, and APP96-110 in excitotoxicity and traumatic brain injury

Perinatal Hypoxic-Ischemic Encephalopathy and Neuroprotective Peptide Therapies: A Case for Cationic Arginine-Rich Peptides (CARPs)

AP-1 inhibitory peptides are neuroprotective following acute glutamate excitotoxicity in primary cortical neuronal cultures

Microglia are both a source and target of extracellular cyclophilin A

Neuroprotective Cationic Arginine-Rich Peptides (CARPs): An Assessment of Their Clinical Safety

The effect of blood pressure (37 vs 45 mmHg) and carotid occlusion duration (8 vs 10 min) on CA1–4 neuronal damage when using isoflurane in a global cerebral ischemia rat model

Assessment of recombinant tissue plasminogen activator (rtPA) toxicity in cultured neural cells and subsequent treatment with poly-arginine peptide R18D

Neuroprotective peptides fused to arginine-rich cell penetrating peptides: Neuroprotective mechanism likely mediated by peptide endocytic properties

Assessment of therapeutic window for poly‐arginine‐18D (R18D) in a P7 rat model of perinatal hypoxic‐ischaemic encephalopathy

Impact of poly-arginine peptides R18D and R18 on alteplase and tenecteplase thrombolysis in vitro, and neuroprotective stability to proteolysis

NCX3 knockout mice exhibit increased hippocampal CA1 and CA2 neuronal damage compared to wild-type mice following global cerebral ischemia

The Neuroprotective Peptide Poly-Arginine-12 (R12) Reduces Cell Surface Levels of NMDA NR2B Receptor Subunit in Cortical Neurons; Investigation into the Involvement of Endocytic Mechanisms

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