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Vinyl Sulfone-Based Peptidomimetics as Anti-Trypanosomal Agents: Design, Synthesis, Biological and Computational Evaluation

Journal of medicinal chemistry, 2013-09, Vol.56 (17), p.6638-6650

2013

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Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line

Cell death and differentiation, 2002-03, Vol.9 (3), p.252-263

2002

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Modulating the Blood-Brain Barrier: A Comprehensive Review

Pharmaceutics, 2021-11, Vol.13 (11), p.1980

2021

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Microfluidics in Haemostasis: A Review

Molecules (Basel, Switzerland), 2020-02, Vol.25 (4), p.833

2020

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Two novel homozygous SLC2A9 mutations cause renal hypouricemia type 2

Nephrology, dialysis, transplantation, 2012-03, Vol.27 (3), p.1035-1041

2012

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Pivotal Study of Iodine I 131 Tositumomab for Chemotherapy-Refractory Low-Grade or Transformed Low-Grade B-Cell Non-Hodgkin’s Lymphomas

Journal of clinical oncology, 2001-10, Vol.19 (19), p.3918-3928

2001

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Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity

Journal of medicinal chemistry, 2018-01, Vol.61 (2), p.514-534

2018

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β‑Lactam Estrogen Receptor Antagonists and a Dual-Targeting Estrogen Receptor/Tubulin Ligand

Journal of medicinal chemistry, 2014-11, Vol.57 (22), p.9370-9382

2014

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Target Specific Virtual Screening: Optimization of an Estrogen Receptor Screening Platform

Journal of medicinal chemistry, 2007-11, Vol.50 (22), p.5301-5310

2007

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Synthesis, biological evaluation, structural–activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators

Bioorganic & medicinal chemistry, 2008-11, Vol.16 (21), p.9554-9573

2008

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Multicenter Phase II Study of Iodine-131 Tositumomab for Chemotherapy-Relapsed/Refractory Low-Grade and Transformed Low-Grade B-Cell Non-Hodgkin’s Lymphomas

Journal of clinical oncology, 2000-03, Vol.18 (6), p.1316-1323

2000

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Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents

Bioorganic & medicinal chemistry, 2011-02, Vol.19 (3), p.1328-1348

2011

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Lead identification of conformationally restricted β-lactam type combretastatin analogues: Synthesis, antiproliferative activity and tubulin targeting effects

European journal of medicinal chemistry, 2010-12, Vol.45 (12), p.5752-5766

2010

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Yttrium-90-labeled anti-CD20 monoclonal antibody therapy of recurrent B-cell lymphoma

Clinical cancer research, 1996-03, Vol.2 (3), p.457-470

1996

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Integration of Ligand and Structure-Based Virtual Screening for the Identification of the First Dual Targeting Agent for Heat Shock Protein 90 (Hsp90) and Tubulin

Journal of medicinal chemistry, 2009-04, Vol.52 (8), p.2177-2180

2009

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'tieredScreen' - Layered Virtual Screening Tool for the Identification of Novel Estrogen Receptor Alpha Modulators

Molecular informatics, 2010-05, Vol.29 (5), p.421-430

2010

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Unbiasing Scoring Functions: A New Normalization and Rescoring Strategy

Journal of chemical information and modeling, 2007-07, Vol.47 (4), p.1564-1571

2007

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Identification of a Small Molecule Inhibitor of Importin β Mediated Nuclear Import by Confocal On-Bead Screening of Tagged One-Bead One-Compound Libraries

ACS chemical biology, 2010-10, Vol.5 (10), p.967-979

2010

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Lead identification of β-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90

Bioorganic & medicinal chemistry, 2011-10, Vol.19 (20), p.6055-6068

2011

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Sofosbuvir plus ribavirin for the treatment of patients with chronic genotype 1 or 6 hepatitis C virus infection in Hong Kong

Alimentary pharmacology & therapeutics, 2016-01, Vol.43 (1), p.96-101

2016

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A phase 3b study of sofosbuvir plus ribavirin in treatment-naive and treatment-experienced Korean patients chronically infected with genotype 2 hepatitis C virus

Journal of viral hepatitis, 2016-05, Vol.23 (5), p.358-365

2016

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The role of radiation-induced apoptosis as a determinant of tumor responses to radiation therapy

Apoptosis (London), 1999-04, Vol.4 (2), p.115-143

1999

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Synthesis and optimisation of P 3 substituted vinyl sulfone-based inhibitors as anti-trypanosomal agents

Bioorganic & medicinal chemistry, 2020-12, Vol.28 (23), p.115774

2020

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Considerations in Compound Database Preparation“Hidden” Impact on Virtual Screening Results

Journal of chemical information and modeling, 2005-11, Vol.45 (6), p.1908-1919

2005

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Direct evidence that apoptosis enhances tumor responses to fractionated radiotherapy

Cancer research (Chicago, Ill.), 1998-05, Vol.58 (9), p.1779-1784

1998

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Vinyl Sulfone-Based Peptidomimetics as Anti-Trypanosomal Agents: Design, Synthesis, Biological and Computational Evaluation

Role of glutathione depletion and reactive oxygen species generation in apoptotic signaling in a human B lymphoma cell line

Modulating the Blood-Brain Barrier: A Comprehensive Review

Microfluidics in Haemostasis: A Review

Two novel homozygous SLC2A9 mutations cause renal hypouricemia type 2

Pivotal Study of Iodine I 131 Tositumomab for Chemotherapy-Refractory Low-Grade or Transformed Low-Grade B-Cell Non-Hodgkin’s Lymphomas

Lead Optimization of Benzoxepin-Type Selective Estrogen Receptor (ER) Modulators and Downregulators with Subtype-Specific ERα and ERβ Activity

β‑Lactam Estrogen Receptor Antagonists and a Dual-Targeting Estrogen Receptor/Tubulin Ligand

Target Specific Virtual Screening: Optimization of an Estrogen Receptor Screening Platform

Synthesis, biological evaluation, structural–activity relationship, and docking study for a series of benzoxepin-derived estrogen receptor modulators

Multicenter Phase II Study of Iodine-131 Tositumomab for Chemotherapy-Relapsed/Refractory Low-Grade and Transformed Low-Grade B-Cell Non-Hodgkin’s Lymphomas

Synthesis and serotonin transporter activity of 1,3-bis(aryl)-2-nitro-1-propenes as a new class of anticancer agents

Lead identification of conformationally restricted β-lactam type combretastatin analogues: Synthesis, antiproliferative activity and tubulin targeting effects

Yttrium-90-labeled anti-CD20 monoclonal antibody therapy of recurrent B-cell lymphoma

Integration of Ligand and Structure-Based Virtual Screening for the Identification of the First Dual Targeting Agent for Heat Shock Protein 90 (Hsp90) and Tubulin

'tieredScreen' - Layered Virtual Screening Tool for the Identification of Novel Estrogen Receptor Alpha Modulators

Unbiasing Scoring Functions: A New Normalization and Rescoring Strategy

Identification of a Small Molecule Inhibitor of Importin β Mediated Nuclear Import by Confocal On-Bead Screening of Tagged One-Bead One-Compound Libraries

Lead identification of β-lactam and related imine inhibitors of the molecular chaperone heat shock protein 90

Sofosbuvir plus ribavirin for the treatment of patients with chronic genotype 1 or 6 hepatitis C virus infection in Hong Kong

A phase 3b study of sofosbuvir plus ribavirin in treatment-naive and treatment-experienced Korean patients chronically infected with genotype 2 hepatitis C virus

The role of radiation-induced apoptosis as a determinant of tumor responses to radiation therapy

Synthesis and optimisation of P 3 substituted vinyl sulfone-based inhibitors as anti-trypanosomal agents

Considerations in Compound Database Preparation“Hidden” Impact on Virtual Screening Results

Direct evidence that apoptosis enhances tumor responses to fractionated radiotherapy

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