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Human airway smooth muscle cells secrete amphiregulin via bradykinin/COX-2/PGE2, inducing COX-2, CXCL8, and VEGF expression in airway epithelial cells

American journal of physiology. Lung cellular and molecular physiology, 2015-08, Vol.309 (3), p.L237-L249

2015

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A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase‐2 in idiopathic pulmonary fibrosis

The FASEB journal, 2014-07, Vol.28 (7), p.3183-3196

2014

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Suberanilohydroxamic acid prevents TGF-β1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation

Biochimica et biophysica acta. Gene regulatory mechanisms, 2018-05, Vol.1861 (5), p.463-472

2018

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Accelerated extracellular matrix turnover during exacerbations of COPD

Respiratory research, 2015-06, Vol.16 (1), p.69-69, Article 69

2015

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CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET

American journal of physiology. Lung cellular and molecular physiology, 2015-05, Vol.308 (9), p.L962-L972

2015

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Inhibition of polyadenylation reduces inflammatory gene induction

RNA (Cambridge), 2012-12, Vol.18 (12), p.2236-2250

2012

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Elevated SP-1 Transcription Factor Expression and Activity Drives Basal and Hypoxia-induced Vascular Endothelial Growth Factor (VEGF) Expression in Non-Small Cell Lung Cancer

The Journal of biological chemistry, 2012-11, Vol.287 (47), p.39967-39981

2012

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Epigenetic dysregulation of interleukin 8 (CXCL8) hypersecretion in cystic fibrosis airway epithelial cells

Biochemical and biophysical research communications, 2016-08, Vol.476 (4), p.431-437

2016

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Synthetic responses in airway smooth muscle

Journal of Allergy and Clinical Immunology, 2004-08, Vol.114 (2), p.S32-S50

2004

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Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD

Clinical epigenetics, 2018-03, Vol.10 (1), p.32-14, Article 32

2018

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Epigenetic Changes in Airway Smooth Muscle as a Driver of Airway Inflammation and Remodeling in Asthma

Chest, 2019-04, Vol.155 (4), p.816-824

2019

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PINX1 and TERT Are Required for TNF-α-Induced Airway Smooth Muscle Chemokine Gene Expression

The Journal of immunology (1950), 2018-02, Vol.200 (4), p.1283-1294

2018

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Transcriptional Regulation of Cyclooxygenase 2 by Bradykinin and Interleukin-1β in Human Airway Smooth Muscle Cells: Involvement of Different Promoter Elements, Transcription Factors, and Histone H4 Acetylation

Molecular and Cellular Biology, 2003-12, Vol.23 (24), p.9233-9244

2003

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Use of a three-dimensional cell culture model to study airway smooth muscle-mast cell interactions in airway remodeling

American journal of physiology. Lung cellular and molecular physiology, 2009-06, Vol.296 (6), p.L1059-L1066

2009

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Interplay between EZH2 and G9a Regulates CXCL10 Gene Repression in Idiopathic Pulmonary Fibrosis

American journal of respiratory cell and molecular biology, 2018-04, Vol.58 (4), p.449-460

2018

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Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

Journal of allergy and clinical immunology, 2015-09, Vol.136 (3), p.769-780

2015

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Transcriptional regulation of inflammatory genes associated with severe asthma

Current pharmaceutical design, 2011-03, Vol.17 (7), p.653-666

2011

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Prostanoids as anti-inflammatory therapy: separating the good from the bad

Thorax, 2015-08, Vol.70 (8), p.711-712

Knox, Alan J

2015

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Endothelin-1 (ET-1) Increases the Expression of Remodeling Genes in Vascular Smooth Muscle through Linked Calcium and cAMP Pathways

The Journal of biological chemistry, 2010-08, Vol.285 (34), p.25913-25927

2010

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Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis

The European respiratory journal, 2015-10, Vol.46 (4), p.1046-1054

2015

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Role of Rho-Associated Coiled-Coil Forming Kinase Isoforms in Regulation of Stiffness-Induced Myofibroblast Differentiation in Lung Fibrosis

American journal of respiratory cell and molecular biology, 2017-06, Vol.56 (6), p.772-783

2017

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CCAAT/Enhancer-binding Protein and Activator Protein-1 Transcription Factors Regulate the Expression of Interleukin-8 through the Mitogen-activated Protein Kinase Pathways in Response to Mechanical Stretch of Human Airway Smooth Muscle Cells

The Journal of biological chemistry, 2003-05, Vol.278 (21), p.18868-18876

2003

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Cyclooxygenase-2 Expression by Nonsteroidal Anti-inflammatory Drugs in Human Airway Smooth Muscle Cells: Role of Peroxisome Proliferator-Activated Receptors

The Journal of immunology (1950), 2003-01, Vol.170 (2), p.1043-1051

2003

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TNFα and IFNγ Synergistically Enhance Transcriptional Activation of CXCL10 in Human Airway Smooth Muscle Cells via STAT-1, NF-κB, and the Transcriptional Coactivator CREB-binding Protein

The Journal of biological chemistry, 2010-09, Vol.285 (38), p.29101-29110

2010

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TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein

The Journal of biological chemistry, 2010-09, Vol.285 (38), p.29101-29110

2010

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Human airway smooth muscle cells secrete amphiregulin via bradykinin/COX-2/PGE2, inducing COX-2, CXCL8, and VEGF expression in airway epithelial cells

A central role for G9a and EZH2 in the epigenetic silencing of cyclooxygenase‐2 in idiopathic pulmonary fibrosis

Suberanilohydroxamic acid prevents TGF-β1-induced COX-2 repression in human lung fibroblasts post-transcriptionally by TIA-1 downregulation

Accelerated extracellular matrix turnover during exacerbations of COPD

CXCL8 histone H3 acetylation is dysfunctional in airway smooth muscle in asthma: regulation by BET

Inhibition of polyadenylation reduces inflammatory gene induction

Elevated SP-1 Transcription Factor Expression and Activity Drives Basal and Hypoxia-induced Vascular Endothelial Growth Factor (VEGF) Expression in Non-Small Cell Lung Cancer

Epigenetic dysregulation of interleukin 8 (CXCL8) hypersecretion in cystic fibrosis airway epithelial cells

Synthetic responses in airway smooth muscle

Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD

Epigenetic Changes in Airway Smooth Muscle as a Driver of Airway Inflammation and Remodeling in Asthma

PINX1 and TERT Are Required for TNF-α-Induced Airway Smooth Muscle Chemokine Gene Expression

Transcriptional Regulation of Cyclooxygenase 2 by Bradykinin and Interleukin-1β in Human Airway Smooth Muscle Cells: Involvement of Different Promoter Elements, Transcription Factors, and Histone H4 Acetylation

Use of a three-dimensional cell culture model to study airway smooth muscle-mast cell interactions in airway remodeling

Interplay between EZH2 and G9a Regulates CXCL10 Gene Repression in Idiopathic Pulmonary Fibrosis

Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

Transcriptional regulation of inflammatory genes associated with severe asthma

Prostanoids as anti-inflammatory therapy: separating the good from the bad

Endothelin-1 (ET-1) Increases the Expression of Remodeling Genes in Vascular Smooth Muscle through Linked Calcium and cAMP Pathways

Pseudomonas aeruginosa quorum sensing molecules correlate with clinical status in cystic fibrosis

Role of Rho-Associated Coiled-Coil Forming Kinase Isoforms in Regulation of Stiffness-Induced Myofibroblast Differentiation in Lung Fibrosis

CCAAT/Enhancer-binding Protein and Activator Protein-1 Transcription Factors Regulate the Expression of Interleukin-8 through the Mitogen-activated Protein Kinase Pathways in Response to Mechanical Stretch of Human Airway Smooth Muscle Cells

Cyclooxygenase-2 Expression by Nonsteroidal Anti-inflammatory Drugs in Human Airway Smooth Muscle Cells: Role of Peroxisome Proliferator-Activated Receptors

TNFα and IFNγ Synergistically Enhance Transcriptional Activation of CXCL10 in Human Airway Smooth Muscle Cells via STAT-1, NF-κB, and the Transcriptional Coactivator CREB-binding Protein

TNFα and IFNγ synergistically enhance transcriptional activation of CXCL10 in human airway smooth muscle cells via STAT-1, NF-κB, and the transcriptional coactivator CREB-binding protein

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