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Using historical control data in bioassays for regulatory toxicology

Regulatory toxicology and pharmacology, 2021-10, Vol.125, p.105024, Article 105024

2021

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Historical control data of rare events: Issues, chronological patterns and their relevance for toxicological evaluations

Regulatory toxicology and pharmacology, 2024-08, Vol.151, p.105673, Article 105673

Kluxen, Felix M.

2024

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Using R in Regulatory Toxicology

EXCLI journal, 2022-08, Vol.21, p.1130-1150

2022

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Molecular effects of ER alpha- and beta-selective agonists on regulation of energy homeostasis in obese female Wistar rats

Molecular and cellular endocrinology, 2013-09, Vol.377 (1-2), p.147-158

2013

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Difficulties in translating in vitro hazards of local acute irritants to relevant human risk: Learnings from Captan and Folpet

Regulatory toxicology and pharmacology, 2023-09, Vol.143, p.105467-105467, Article 105467

Kluxen, Felix M.

2023

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“New statistics” in regulatory toxicology?

Regulatory toxicology and pharmacology, 2020-11, Vol.117, p.104763, Article 104763

Kluxen, Felix M.

2020

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Scatter plotting as a simple tool to analyse relative organ to body weight in toxicological bioassays

Archives of toxicology, 2019-08, Vol.93 (8), p.2409-2420

Kluxen, Felix M.

2019

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Lifelong exposure to dietary isoflavones reduces risk of obesity in ovariectomized Wistar rats

Molecular nutrition & food research, 2015-12, Vol.59 (12), p.2407-2418

2015

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A Review of Recent Advances in Benchmark Dose Methodology

Risk analysis, 2019-10, Vol.39 (10), p.2295-2315

2019

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Understanding and overcoming the technical challenges in using in silico predictions in regulatory decisions of complex toxicological endpoints – A pesticide perspective for regulatory toxicologists with a focus on machine learning models

Regulatory toxicology and pharmacology, 2023-01, Vol.137, p.105311-105311, Article 105311

2023

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Benchmark dose modelling in regulatory ecotoxicology, a potential tool in pest management

Pest management science, 2022-05, Vol.78 (5), p.1772-1779

2022

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Developing a pragmatic consensus procedure supporting the ICH S1B(R1) weight of evidence carcinogenicity assessment

Frontiers in toxicology, 2024, Vol.6, p.1370045-1370045

2024

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Review of air concentrations of pesticides for estimating exposure to vapour in European risk assessments

Regulatory toxicology and pharmacology, 2022-07, Vol.132, p.105172-105172, Article 105172

2022

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The database makes the poison: How the selection of datasets in QSAR models impacts toxicant prediction of higher tier endpoints

Regulatory toxicology and pharmacology, 2024-08, Vol.151, p.105663, Article 105663

2024

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Metribuzin-induced non-adverse liver changes result in rodent-specific non-adverse thyroid effects via uridine 5′-diphospho-glucuronosyltransferase (UDPGT, UGT) modulation

Regulatory toxicology and pharmacology, 2021-06, Vol.122, p.104884, Article 104884

2021

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The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol

Archives of toxicology, 2013-04, Vol.87 (4), p.633-643

2013

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Proposals for new transfer coefficient (TC) values for worker re-entry activities in grape vineyards

Regulatory toxicology and pharmacology, 2024-06, Vol.150, p.105628-105628, Article 105628

2024

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Proposals for new spray drift exposure values in orchards and vineyards for residents and bystanders

Regulatory toxicology and pharmacology, 2024-06, Vol.150, p.105643-105643, Article 105643

2024

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A Nonmechanistic Parametric Modeling Approach for Benchmark Dose Estimation of Event‐Time Data

Risk analysis, 2021-11, Vol.41 (11), p.2081-2093

2021

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Alternatives to statistical decision trees in regulatory (eco-)toxicological bioassays

Archives of toxicology, 2020-04, Vol.94 (4), p.1135-1149

2020

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Use of guinea pig data to obtain starting points for skin sensitisation risk assessment - A commentary

Regulatory toxicology and pharmacology, 2024-03, Vol.148, p.105584-105584, Article 105584

2024

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Expanding the toxicologist's statistical toolbox: Using effect size estimation and dose-response modelling for holistic assessments instead of generic testing

Regulatory toxicology and pharmacology, 2021-04, Vol.121, p.104871, Article 104871

2021

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Assessing the risk of induction of skin sensitization to plant protection products: A quantitative approach

Regulatory toxicology and pharmacology, 2023-06, Vol.141, p.105408-105408, Article 105408

2023

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Investigations on the estrogenic activity of the metallohormone cadmium in the rat intestine

Archives of toxicology, 2010-07, Vol.84 (7), p.541-552

2010

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Compounded conservatism in European re-entry worker risk assessment of pesticides

Regulatory toxicology and pharmacology, 2021-04, Vol.121, p.104864, Article 104864

2021

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Using historical control data in bioassays for regulatory toxicology

Historical control data of rare events: Issues, chronological patterns and their relevance for toxicological evaluations

Using R in Regulatory Toxicology

Molecular effects of ER alpha- and beta-selective agonists on regulation of energy homeostasis in obese female Wistar rats

Difficulties in translating in vitro hazards of local acute irritants to relevant human risk: Learnings from Captan and Folpet

“New statistics” in regulatory toxicology?

Scatter plotting as a simple tool to analyse relative organ to body weight in toxicological bioassays

Lifelong exposure to dietary isoflavones reduces risk of obesity in ovariectomized Wistar rats

A Review of Recent Advances in Benchmark Dose Methodology

Understanding and overcoming the technical challenges in using in silico predictions in regulatory decisions of complex toxicological endpoints – A pesticide perspective for regulatory toxicologists with a focus on machine learning models

Benchmark dose modelling in regulatory ecotoxicology, a potential tool in pest management

Developing a pragmatic consensus procedure supporting the ICH S1B(R1) weight of evidence carcinogenicity assessment

Review of air concentrations of pesticides for estimating exposure to vapour in European risk assessments

The database makes the poison: How the selection of datasets in QSAR models impacts toxicant prediction of higher tier endpoints

Metribuzin-induced non-adverse liver changes result in rodent-specific non-adverse thyroid effects via uridine 5′-diphospho-glucuronosyltransferase (UDPGT, UGT) modulation

The metallohormone cadmium modulates AhR-associated gene expression in the small intestine of rats similar to ethinyl-estradiol

Proposals for new transfer coefficient (TC) values for worker re-entry activities in grape vineyards

Proposals for new spray drift exposure values in orchards and vineyards for residents and bystanders

A Nonmechanistic Parametric Modeling Approach for Benchmark Dose Estimation of Event‐Time Data

Alternatives to statistical decision trees in regulatory (eco-)toxicological bioassays

Use of guinea pig data to obtain starting points for skin sensitisation risk assessment - A commentary

Expanding the toxicologist's statistical toolbox: Using effect size estimation and dose-response modelling for holistic assessments instead of generic testing

Assessing the risk of induction of skin sensitization to plant protection products: A quantitative approach

Investigations on the estrogenic activity of the metallohormone cadmium in the rat intestine

Compounded conservatism in European re-entry worker risk assessment of pesticides

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