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High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein

Proceedings of the National Academy of Sciences - PNAS, 2015-12, Vol.112 (49), p.15196-15201

2015

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In Vivo Emergence of a Novel Mutant L159F/L320F in the NS5B Polymerase Confers Low-Level Resistance to the HCV Polymerase Inhibitors Mericitabine and Sofosbuvir

The Journal of infectious diseases, 2014-03, Vol.209 (5), p.668-675

2014

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Recent progress in the design of small molecule inhibitors of HIV RNase H

Current pharmaceutical design, 2006-05, Vol.12 (15), p.1909

2006

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Assembly, Purification, and Pre-steady-state Kinetic Analysis of Active RNA-dependent RNA Polymerase Elongation Complex

The Journal of biological chemistry, 2012-03, Vol.287 (13), p.10674-10683

2012

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Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage

Nucleic acids research, 2013-09, Vol.41 (17), p.8289

2013

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NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase

Proceedings of the National Academy of Sciences - PNAS, 2013-01, Vol.110 (5), p.E348-E357

2013

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Transcriptomic analysis of the woodchuck model of chronic hepatitis B

Hepatology (Baltimore, Md.), 2012-09, Vol.56 (3), p.820-830

2012

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Determination of neuraminidase kinetic constants using whole influenza virus preparations and correction for spectroscopic interference by a fluorogenic substrate

PloS one, 2013-08, Vol.8 (8), p.e71401-e71401

2013

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Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479

Antimicrobial Agents and Chemotherapy, 2008-12, Vol.52 (12), p.4356-4369

2008

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H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load

mBio, 2011-11, Vol.2 (5)

2011

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The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture

The Journal of biological chemistry, 2006-02, Vol.281 (7), p.3793-3799

2006

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A Serine Palmitoyltransferase Inhibitor Blocks Hepatitis C Virus Replication in Human Hepatocytes

Gastroenterology (New York, N.Y. 1943), 2013-10, Vol.145 (4), p.865-873

2013

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Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus

The Journal of biological chemistry, 2009-06, Vol.284 (23), p.15517-15529

2009

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In vitro selected Con1 subgenomic replicons resistant to 2′-C-Methyl-Cytidine or to R1479 show lack of cross resistance

Virology (New York, N.Y.), 2006-08, Vol.351 (2), p.349-359

2006

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Essential Role of the N-terminal Domain in the Regulation of RIG-I ATPase Activity

The Journal of biological chemistry, 2008-04, Vol.283 (14), p.9488-9496

2008

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Structure of the Unphosphorylated STAT5a Dimer

The Journal of biological chemistry, 2005-12, Vol.280 (49), p.40782-40787

2005

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Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

Journal of Virology, 2006-06, Vol.80 (12), p.6146-6154

2006

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First Example of Phosphoramidate Approach Applied to a 4‘-Substituted Purine Nucleoside (4‘-Azidoadenosine): Conversion of an Inactive Nucleoside to a Submicromolar Compound versus Hepatitis C Virus

Journal of medicinal chemistry, 2007-11, Vol.50 (22), p.5463-5470

2007

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Use of a Pharmacophore Model To Discover a New Class of Influenza Endonuclease Inhibitors

Journal of medicinal chemistry, 2003-03, Vol.46 (7), p.1153-1164

2003

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Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs)

Biochemical and biophysical research communications, 2007-01, Vol.352 (2), p.341-350

2007

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Target-mediated drug disposition and prolonged liver accumulation of a novel humanized anti-CD81 monoclonal antibody in cynomolgus monkeys

mAbs, 2013-09, Vol.5 (5), p.776-786

2013

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Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection

Gastroenterology (New York, N.Y. 1943), 2018-02, Vol.154 (3), p.652-662.e8

2018

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Optimization of small molecule drugs binding to highly polar target sites: lessons from the discovery and development of neuraminidase inhibitors

Current topics in medicinal chemistry, 2006-03, Vol.6 (5), p.423

2006

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Reconstitution and Functional Analysis of a Full-Length Hepatitis C Virus NS5B Polymerase on a Supported Lipid Bilayer

ACS central science, 2016-07, Vol.2 (7), p.456-466

2016

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Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19

Nature (London), 2022-05, Vol.605 (7908), p.146-151

2022

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High-resolution crystal structure of a hepatitis B virus replication inhibitor bound to the viral core protein

In Vivo Emergence of a Novel Mutant L159F/L320F in the NS5B Polymerase Confers Low-Level Resistance to the HCV Polymerase Inhibitors Mericitabine and Sofosbuvir

Recent progress in the design of small molecule inhibitors of HIV RNase H

Assembly, Purification, and Pre-steady-state Kinetic Analysis of Active RNA-dependent RNA Polymerase Elongation Complex

Characterization of PA-N terminal domain of Influenza A polymerase reveals sequence specific RNA cleavage

NTP-mediated nucleotide excision activity of hepatitis C virus RNA-dependent RNA polymerase

Transcriptomic analysis of the woodchuck model of chronic hepatitis B

Determination of neuraminidase kinetic constants using whole influenza virus preparations and correction for spectroscopic interference by a fluorogenic substrate

Selected Replicon Variants with Low-Level In Vitro Resistance to the Hepatitis C Virus NS5B Polymerase Inhibitor PSI-6130 Lack Cross-Resistance with R1479

H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load

The Novel Nucleoside Analog R1479 (4′-Azidocytidine) Is a Potent Inhibitor of NS5B-dependent RNA Synthesis and Hepatitis C Virus Replication in Cell Culture

A Serine Palmitoyltransferase Inhibitor Blocks Hepatitis C Virus Replication in Human Hepatocytes

Slow Binding Inhibition and Mechanism of Resistance of Non-nucleoside Polymerase Inhibitors of Hepatitis C Virus

In vitro selected Con1 subgenomic replicons resistant to 2′-C-Methyl-Cytidine or to R1479 show lack of cross resistance

Essential Role of the N-terminal Domain in the Regulation of RIG-I ATPase Activity

Structure of the Unphosphorylated STAT5a Dimer

Selection and Characterization of Replicon Variants Dually Resistant to Thumb- and Palm-Binding Nonnucleoside Polymerase Inhibitors of the Hepatitis C Virus

First Example of Phosphoramidate Approach Applied to a 4‘-Substituted Purine Nucleoside (4‘-Azidoadenosine): Conversion of an Inactive Nucleoside to a Submicromolar Compound versus Hepatitis C Virus

Use of a Pharmacophore Model To Discover a New Class of Influenza Endonuclease Inhibitors

Substrate-dependent inhibition or stimulation of HIV RNase H activity by non-nucleoside reverse transcriptase inhibitors (NNRTIs)

Target-mediated drug disposition and prolonged liver accumulation of a novel humanized anti-CD81 monoclonal antibody in cynomolgus monkeys

Efficacy of NVR 3-778, Alone and In Combination With Pegylated Interferon, vs Entecavir In uPA/SCID Mice With Humanized Livers and HBV Infection

Optimization of small molecule drugs binding to highly polar target sites: lessons from the discovery and development of neuraminidase inhibitors

Reconstitution and Functional Analysis of a Full-Length Hepatitis C Virus NS5B Polymerase on a Supported Lipid Bilayer

Eicosanoid signalling blockade protects middle-aged mice from severe COVID-19

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