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Tibolone: a steroid with a tissue-specific mode of action

Journal of steroid biochemistry and molecular biology, 2001-01, Vol.76 (1), p.231-238

Kloosterboer, H.J

2001

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Development of Time-Resolved Immunofluorometric Assays for Rat Follicle-Stimulating Hormone and Luteinizing Hormone and Application on Sera of Cycling Rats

Biology of reproduction, 2000-04, Vol.62 (4), p.886-894

2000

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Selective tissue distribution of tibolone metabolites in mature ovariectomized female cynomolgus monkeys after multiple doses of tibolone

Drug metabolism and disposition, 2007-07, Vol.35 (7), p.1105

2007

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Pros and cons of existing treatment modalities in osteoporosis: a comparison between tibolone, SERMs and estrogen (±progestogen) treatments

Journal of steroid biochemistry and molecular biology, 2002-12, Vol.83 (1), p.157-165

2002

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Metabolism of exogenous sex steroids and effect on brain functions with a focus on tibolone

Journal of steroid biochemistry and molecular biology, 2006-12, Vol.102 (1), p.195-204

2006

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Tibolone Rapidly Attenuates the GABAB Response in Hypothalamic Neurones

Journal of neuroendocrinology, 2008-12, Vol.20 (12), p.1310-1318

2008

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Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents

The Journal of clinical investigation, 1998-08, Vol.102 (3), p.532-537

1998

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Pharmacokinetic parameters of tibolone and metabolites in plasma, urine, feces, and bile from ovariectomized cynomolgus monkeys after a single dose or multiple doses of tibolone

Drug metabolism and disposition, 2007-07, Vol.35 (7), p.1112

2007

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Tissue-selective effects of tibolone on the breast

Maturitas, 2004-09, Vol.49 (1), p.S5-S15

Kloosterboer, H.J.

2004

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Tibolone Exerts Its Protective Effect on Trabecular Bone Loss Through the Estrogen Receptor

Journal of bone and mineral research, 2001-09, Vol.16 (9), p.1651-1657

2001

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Development and Characterization of an In Vitro Ovulation Model Using Mouse Ovarian Follicles

Biology of reproduction, 1999-08, Vol.61 (2), p.503-511

1999

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Effect of tibolone (Org OD14) and its metabolites on estrone sulphatase activity in MCF-7 and T-47D mammary cancer cells

Anticancer research, 1997-01, Vol.17 (1A), p.135

1997

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Historical milestones in the development of tibolone (Livial®)

Climacteric : the journal of the International Menopause Society, 2011-12, Vol.14 (6), p.609-621

Kloosterboer, H. J.

2011

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Molecular Portrait of the Progestagenic and Estrogenic Actions of Tibolone: Behavior of Cellular Networks in Response to Tibolone

The journal of clinical endocrinology and metabolism, 2005-02, Vol.90 (2), p.973-983

2005

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Effects of stable transfection of human fetal osteoblast cells with estrogen receptor-alpha on regulation of gene expression by tibolone

Bone (New York, N.Y.), 2006-09, Vol.39 (3), p.523-529

2006

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In vitro effects of tibolone and its metabolites on human vascular coronary cells

Maturitas, 2007-09, Vol.58 (1), p.42-49

2007

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Pharmacokinetic Parameters of Sulfated Tibolone Metabolites in Postmenopausal Women after Single and Multiple Doses of Tibolone

Clinical pharmacology and therapeutics, 2007-04, Vol.81 (4), p.573-579

2007

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Progestagenic Effects of Tibolone on Human Endometrial Cancer Cells

The journal of clinical endocrinology and metabolism, 2003-05, Vol.88 (5), p.2327-2334

2003

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Molecular analysis of human endometrium : short-term tibolone signaling differs significantly from estrogen and estrogen + progestagen signaling

Journal of molecular medicine (Berlin, Germany), 2007-05, Vol.85 (5), p.471-480

2007

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Effect of 16 Months of Treatment with Tibolone on Bone Mass, Turnover, and Biomechanical Quality in Mature Ovariectomized Rats

Journal of bone and mineral research, 2001-09, Vol.16 (9), p.1674-1681

2001

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Isoforms of Human Recombinant Follicle-Stimulating Hormone: Comparison of Effects on Murine Follicle Development In Vitro

Biology of reproduction, 1998-10, Vol.59 (4), p.854-861

1998

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Tibolone, a Steroid with a Tissue‐Specific Hormonal Profile, Completely Prevents Ovariectomy‐Induced Bone Loss in Sexually Mature Rats

Journal of bone and mineral research, 1999-11, Vol.14 (11), p.1963-1970

1999

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Tibolone actions on normal and breast cancer cells

European journal of cancer (1990), 2000-09, Vol.36, p.76-77

2000

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Hormonal properties of norethisterone, 7α-methyl-norethisterone and their derivatives

The Journal of steroid biochemistry and molecular biology, 2000-11, Vol.74 (4), p.213-222

2000

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Metabolism of tibolone and its metabolites in uterine and vaginal tissue of rat and human origin

The Journal of steroid biochemistry and molecular biology, 2006-09, Vol.101 (1), p.42-49

2006

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Tibolone: a steroid with a tissue-specific mode of action

Development of Time-Resolved Immunofluorometric Assays for Rat Follicle-Stimulating Hormone and Luteinizing Hormone and Application on Sera of Cycling Rats

Selective tissue distribution of tibolone metabolites in mature ovariectomized female cynomolgus monkeys after multiple doses of tibolone

Pros and cons of existing treatment modalities in osteoporosis: a comparison between tibolone, SERMs and estrogen (±progestogen) treatments

Metabolism of exogenous sex steroids and effect on brain functions with a focus on tibolone

Tibolone Rapidly Attenuates the GABAB Response in Hypothalamic Neurones

Phosphodiesterase 3 inhibitors suppress oocyte maturation and consequent pregnancy without affecting ovulation and cyclicity in rodents

Pharmacokinetic parameters of tibolone and metabolites in plasma, urine, feces, and bile from ovariectomized cynomolgus monkeys after a single dose or multiple doses of tibolone

Tissue-selective effects of tibolone on the breast

Tibolone Exerts Its Protective Effect on Trabecular Bone Loss Through the Estrogen Receptor

Development and Characterization of an In Vitro Ovulation Model Using Mouse Ovarian Follicles

Effect of tibolone (Org OD14) and its metabolites on estrone sulphatase activity in MCF-7 and T-47D mammary cancer cells

Historical milestones in the development of tibolone (Livial®)

Molecular Portrait of the Progestagenic and Estrogenic Actions of Tibolone: Behavior of Cellular Networks in Response to Tibolone

Effects of stable transfection of human fetal osteoblast cells with estrogen receptor-alpha on regulation of gene expression by tibolone

In vitro effects of tibolone and its metabolites on human vascular coronary cells

Pharmacokinetic Parameters of Sulfated Tibolone Metabolites in Postmenopausal Women after Single and Multiple Doses of Tibolone

Progestagenic Effects of Tibolone on Human Endometrial Cancer Cells

Molecular analysis of human endometrium : short-term tibolone signaling differs significantly from estrogen and estrogen + progestagen signaling

Effect of 16 Months of Treatment with Tibolone on Bone Mass, Turnover, and Biomechanical Quality in Mature Ovariectomized Rats

Isoforms of Human Recombinant Follicle-Stimulating Hormone: Comparison of Effects on Murine Follicle Development In Vitro

Tibolone, a Steroid with a Tissue‐Specific Hormonal Profile, Completely Prevents Ovariectomy‐Induced Bone Loss in Sexually Mature Rats

Tibolone actions on normal and breast cancer cells

Hormonal properties of norethisterone, 7α-methyl-norethisterone and their derivatives

Metabolism of tibolone and its metabolites in uterine and vaginal tissue of rat and human origin

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