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E2 enzymes： more than just middle men

Cell research, 2016-04, Vol.26 (4), p.423-440

2016

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Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases

Molecular cell, 2012-09, Vol.47 (6), p.933-942

2012

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The Acidic Transcription Activator Gcn4 Binds the Mediator Subunit Gal11/Med15 Using a Simple Protein Interface Forming a Fuzzy Complex

Molecular cell, 2011-12, Vol.44 (6), p.942-953

2011

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Mutations in LARS2, Encoding Mitochondrial Leucyl-tRNA Synthetase, Lead to Premature Ovarian Failure and Hearing Loss in Perrault Syndrome

American journal of human genetics, 2013-04, Vol.92 (4), p.614-620

2013

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HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation

The Journal of biological chemistry, 2018-02, Vol.293 (8), p.2687-2700

2018

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E2s: structurally economical and functionally replete

Biochemical journal, 2011-01, Vol.433 (1), p.31-42

2011

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Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex

Cell reports (Cambridge), 2018-03, Vol.22 (12), p.3251-3264

2018

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Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal

Nature (London), 2015-01, Vol.517 (7533), p.223-226

2015

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Mediator subunit Med15 dictates the conserved “fuzzy” binding mechanism of yeast transcription activators Gal4 and Gcn4

Nature communications, 2021-04, Vol.12 (1), p.2220-2220, Article 2220

2021

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E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages

Nature structural & molecular biology, 2007-10, Vol.14 (10), p.941-948

2007

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A Bifunctional Role for the UHRF1 UBL Domain in the Control of Hemi-methylated DNA-Dependent Histone Ubiquitylation

Molecular cell, 2018-11, Vol.72 (4), p.753-765.e6

2018

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Proof of principle for epitope-focused vaccine design

Nature (London), 2014-03, Vol.507 (7491), p.201-206

2014

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OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function

Molecular cell, 2012-02, Vol.45 (3), p.384-397

2012

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Release of a disordered domain enhances HspB1 chaperone activity toward tau

Proceedings of the National Academy of Sciences - PNAS, 2020-02, Vol.117 (6), p.2923-2929

2020

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Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage

Cancer research (Chicago, Ill.), 2015-04, Vol.75 (7), p.1311-1321

2015

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Regulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin Ligases

The Journal of biological chemistry, 2015-08, Vol.290 (35), p.21244-21251

2015

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Mechanism of phosphoribosyl-ubiquitination mediated by a single Legionella effector

Nature (London), 2018-05, Vol.557 (7707), p.729-733

2018

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sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface

Proceedings of the National Academy of Sciences - PNAS, 2014-08, Vol.111 (34), p.E3506-E3513

2014

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Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome

Proceedings of the National Academy of Sciences - PNAS, 2011-04, Vol.108 (16), p.6543-6548

2011

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Characterization of RING-Between-RING E3 Ubiquitin Transfer Mechanisms

Methods in molecular biology (Clifton, N.J.), 2018-01, Vol.1844, p.3

2018

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Conservation of transcriptional regulation by BRCA1 and BARD1 in Caenorhabditis elegans

Nucleic acids research, 2023-03, Vol.51 (5), p.2108-2116

2023

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Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis

Proceedings of the National Academy of Sciences - PNAS, 2013-04, Vol.110 (14), p.5287-5287

2013

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Mutations in the DBP-Deficiency Protein HSD17B4 Cause Ovarian Dysgenesis, Hearing Loss, and Ataxia of Perrault Syndrome

American journal of human genetics, 2010-08, Vol.87 (2), p.282-288

2010

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Cbl interacts with multiple E2s in vitro and in cells

PloS one, 2019-05, Vol.14 (5), p.e0216967-e0216967

2019

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E2 enzymes： more than just middle men

Structure of an E3:E2∼Ub Complex Reveals an Allosteric Mechanism Shared among RING/U-box Ligases

The Acidic Transcription Activator Gcn4 Binds the Mediator Subunit Gal11/Med15 Using a Simple Protein Interface Forming a Fuzzy Complex

Mutations in LARS2, Encoding Mitochondrial Leucyl-tRNA Synthetase, Lead to Premature Ovarian Failure and Hearing Loss in Perrault Syndrome

HspB1 and Hsc70 chaperones engage distinct tau species and have different inhibitory effects on amyloid formation

E2s: structurally economical and functionally replete

Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex

Allosteric activation of the RNF146 ubiquitin ligase by a poly(ADP-ribosyl)ation signal

Mediator subunit Med15 dictates the conserved “fuzzy” binding mechanism of yeast transcription activators Gal4 and Gcn4

E2-BRCA1 RING interactions dictate synthesis of mono- or specific polyubiquitin chain linkages

A Bifunctional Role for the UHRF1 UBL Domain in the Control of Hemi-methylated DNA-Dependent Histone Ubiquitylation

Proof of principle for epitope-focused vaccine design

OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function

Release of a disordered domain enhances HspB1 chaperone activity toward tau

Interaction of BARD1 and HP1 Is Required for BRCA1 Retention at Sites of DNA Damage

Regulating the Regulators: Recent Revelations in the Control of E3 Ubiquitin Ligases

Mechanism of phosphoribosyl-ubiquitination mediated by a single Legionella effector

sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface

The growing world of small heat shock proteins: from structure to functions

Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome

Characterization of RING-Between-RING E3 Ubiquitin Transfer Mechanisms

Conservation of transcriptional regulation by BRCA1 and BARD1 in Caenorhabditis elegans

Activity-enhancing mutations in an E3 ubiquitin ligase identified by high-throughput mutagenesis

Mutations in the DBP-Deficiency Protein HSD17B4 Cause Ovarian Dysgenesis, Hearing Loss, and Ataxia of Perrault Syndrome

Cbl interacts with multiple E2s in vitro and in cells

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