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Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice : Influence of sex and inhibitors

Bioorganic & medicinal chemistry, 2006, Vol.14 (1), p.62-66

2006

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Pharmacogenetically driven patient selection for a first-in-human phase I trial of batracylin in patients with advanced solid tumors and lymphomas

Cancer chemotherapy and pharmacology, 2013-10, Vol.72 (4), p.917-923

2013

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Glucuronidation of 3′-Azido-3′-Deoxythymidine (Zidovudine) by Human Liver Microsomes: Relevance to Clinical Pharmacokinetic Interactions with Atovaquone, Fluconazole, Methadone, and Valproic Acid

Antimicrobial Agents and Chemotherapy, 1998-07, Vol.42 (7), p.1592-1596

1998

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Metabolic profile of XK469 (2(R)-[4-(7-chloro-2-quinoxalinyl)oxyphenoxy]-propionic acid; NSC698215) in patients and in vitro: low potential for active or toxic metabolites or for drug-drug interactions

Cancer chemotherapy and pharmacology, 2005-10, Vol.56 (4), p.351-357

2005

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Synthesis of 2′-deoxy-2′-[ 18F]fluoro-β-D-arabinofuranosyl nucleosides, [ 18F]FAU, [ 18F]FMAU, [ 18F]FBAU and [ 18F]FIAU, as potential PET agents for imaging cellular proliferation : synthesis of [ 18F]labelled FAU, FMAU, FBAU, FIAU

Nuclear medicine and biology, 2003-04, Vol.30 (3), p.215-224

2003

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Reversal of Adriamycin Resistance by Verapamil in Human Ovarian Cancer

Science (American Association for the Advancement of Science), 1984-06, Vol.224 (4652), p.994-996

1984

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Evaluation of highly bound drugs: interspecies, intersubject, and related comparisons

Journal of clinical pharmacology, 2002-09, Vol.42 (9), p.971-975

2002

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Biodistribution and Radiation Dosimetry Estimates of 1-(2'-Deoxy-2'-18F-Fluoro-1-{beta}-D-Arabinofuranosyl)-5-Bromouracil: PET Imaging Studies in Dogs

The Journal of nuclear medicine (1978), 2005-11, Vol.46 (11), p.1916

2005

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Radiosynthesis of [11C]paclitaxel

Journal of labelled compounds & radiopharmaceuticals, 2002-05, Vol.45 (6), p.471-477

2002

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Distribution of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) uracil in mice bearing colorectal cancer xenografts: Rationale for therapeutic use and as a positron emission tomography probe for thymidylate synthase

Clinical cancer research, 2004-10, Vol.10 (19), p.6669-6676

2004

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Plasma and cerebrospinal fluid pharmacokinetics of 3′-azido-3′-deoxythymidine: A Novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases

Clinical pharmacology and therapeutics, 1987-04, Vol.41 (4), p.407-412

1987

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Suicide Prodrugs Activated by Thymidylate Synthase: Rationale for Treatment and Noninvasive Imaging of Tumors with Deoxyuridine Analogues

Clinical cancer research, 1999-08, Vol.5 (8), p.1976-1981

1999

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Metabolism by N-Acetyltransferase 1 In Vitro and in Healthy Volunteers: A Prototype for Targeted Inhibition

Journal of clinical pharmacology, 2004-12, Vol.44 (12), p.1405-1411

2004

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Thymidine phosphorylase as a target for imaging and therapy with thymine analogs

Cancer chemotherapy and pharmacology, 2001-11, Vol.48 (5), p.407-412

2001

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Distribution of 1-(2-Deoxy-2-fluoro-β-d-arabinofuranosyl) Uracil in Mice Bearing Colorectal Cancer Xenografts

Clinical cancer research, 2004-10, Vol.10 (19), p.6669-6676

2004

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Evaluation of Highly Bound Drugs: Interspecies, Intersubject, and Related Comparisons

Journal of clinical pharmacology, 2002-09, Vol.42 (9), p.971-975

2002

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Biodistribution and radiation dosimetry estimates of 1-(2'-deoxy-2'-(18)F-Fluoro-1-beta-D-arabinofuranosyl)-5-bromouracil: PET imaging studies in dogs

The Journal of nuclear medicine (1978), 2005-11, Vol.46 (11), p.1916

2005

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Stereoselective Metabolism of Fenoldopam and Its Metabolites in Human Liver Microsomes, Cytosol, and Slices

Journal of cardiovascular pharmacology, 1997-07, Vol.30 (1), p.69-74

1997

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Selenium-induced cytotoxicity of human leukemia cells: interaction with reduced glutathione

Cancer research (Chicago, Ill.), 1986-11, Vol.46 (11), p.5482-5485

1986

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Pharmacokinetics of 2',3'-Dideoxycytidine in Patients with AIDS and Related Disorders

Journal of clinical pharmacology, 1988-09, Vol.28 (9), p.837-842

1988

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Effect of the mutation of tyrosine 713 in p93c-fes on its catalytic activity and ability to promote myeloid differentiation in K562 cells

Biochemistry (Easton), 1993-07, Vol.32 (27), p.6995-7001

1993

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Pharmacological evaluation of intravenous delivery of 5-bromodeoxyuridine to patients with brain tumors

Cancer research (Chicago, Ill.), 1984-04, Vol.44 (4), p.1702-1705

1984

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Portal levels and hepatic clearance of 5-fluorouracil after intraperitoneal administration in humans

Cancer research (Chicago, Ill.), 1981-05, Vol.41 (5), p.1916-1922

1981

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Clinical Pharmacokinetics of Suramin in Patients With HTLV-III/LAV Infection

Journal of clinical pharmacology, 1986-01, Vol.26 (1), p.22-26

1986

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Clinical pharmacology of 5-iodo-2′-deoxyuridine and 5-iodouracil and endogenous pyrimidine modulation

Clinical pharmacology and therapeutics, 1985-07, Vol.38 (1), p.45-51

1985

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Zebularine metabolism by aldehyde oxidase in hepatic cytosol from humans, monkeys, dogs, rats, and mice : Influence of sex and inhibitors

Pharmacogenetically driven patient selection for a first-in-human phase I trial of batracylin in patients with advanced solid tumors and lymphomas

Glucuronidation of 3′-Azido-3′-Deoxythymidine (Zidovudine) by Human Liver Microsomes: Relevance to Clinical Pharmacokinetic Interactions with Atovaquone, Fluconazole, Methadone, and Valproic Acid

Metabolic profile of XK469 (2(R)-[4-(7-chloro-2-quinoxalinyl)oxyphenoxy]-propionic acid; NSC698215) in patients and in vitro: low potential for active or toxic metabolites or for drug-drug interactions

Synthesis of 2′-deoxy-2′-[ 18F]fluoro-β-D-arabinofuranosyl nucleosides, [ 18F]FAU, [ 18F]FMAU, [ 18F]FBAU and [ 18F]FIAU, as potential PET agents for imaging cellular proliferation : synthesis of [ 18F]labelled FAU, FMAU, FBAU, FIAU

Reversal of Adriamycin Resistance by Verapamil in Human Ovarian Cancer

Evaluation of highly bound drugs: interspecies, intersubject, and related comparisons

Biodistribution and Radiation Dosimetry Estimates of 1-(2'-Deoxy-2'-18F-Fluoro-1-{beta}-D-Arabinofuranosyl)-5-Bromouracil: PET Imaging Studies in Dogs

Radiosynthesis of [11C]paclitaxel

Distribution of 1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl) uracil in mice bearing colorectal cancer xenografts: Rationale for therapeutic use and as a positron emission tomography probe for thymidylate synthase

Plasma and cerebrospinal fluid pharmacokinetics of 3′-azido-3′-deoxythymidine: A Novel pyrimidine analog with potential application for the treatment of patients with AIDS and related diseases

Suicide Prodrugs Activated by Thymidylate Synthase: Rationale for Treatment and Noninvasive Imaging of Tumors with Deoxyuridine Analogues

Metabolism by N-Acetyltransferase 1 In Vitro and in Healthy Volunteers: A Prototype for Targeted Inhibition

Thymidine phosphorylase as a target for imaging and therapy with thymine analogs

Distribution of 1-(2-Deoxy-2-fluoro-β-d-arabinofuranosyl) Uracil in Mice Bearing Colorectal Cancer Xenografts

Evaluation of Highly Bound Drugs: Interspecies, Intersubject, and Related Comparisons

Biodistribution and radiation dosimetry estimates of 1-(2'-deoxy-2'-(18)F-Fluoro-1-beta-D-arabinofuranosyl)-5-bromouracil: PET imaging studies in dogs

Stereoselective Metabolism of Fenoldopam and Its Metabolites in Human Liver Microsomes, Cytosol, and Slices

Selenium-induced cytotoxicity of human leukemia cells: interaction with reduced glutathione

Pharmacokinetics of 2',3'-Dideoxycytidine in Patients with AIDS and Related Disorders

Effect of the mutation of tyrosine 713 in p93c-fes on its catalytic activity and ability to promote myeloid differentiation in K562 cells

Pharmacological evaluation of intravenous delivery of 5-bromodeoxyuridine to patients with brain tumors

Portal levels and hepatic clearance of 5-fluorouracil after intraperitoneal administration in humans

Clinical Pharmacokinetics of Suramin in Patients With HTLV-III/LAV Infection

Clinical pharmacology of 5-iodo-2′-deoxyuridine and 5-iodouracil and endogenous pyrimidine modulation

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