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Enhanced disulphide bond stability contributes to the once-weekly profile of insulin icodec

Nature communications, 2024-07, Vol.15 (1), p.6124-11, Article 6124

2024

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Molecular Engineering of Insulin Icodec, the First Acylated Insulin Analog for Once-Weekly Administration in Humans

Journal of medicinal chemistry, 2021-07, Vol.64 (13), p.8942-8950

2021

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Predicting human half-life for insulin analogs: An inter-drug approach

European journal of pharmaceutics and biopharmaceutics, 2024-08, Vol.201, p.114375, Article 114375

2024

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Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.616-628

2021

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Molecular Engineering of Efficacious Mono-Valent Ultra-Long Acting Two-Chain Insulin-Fc Conjugates

Journal of medicinal chemistry, 2022-02, Vol.65 (3), p.2633-2645

2022

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Changes in glucose and fat metabolism in response to the administration of a hepato-preferential insulin analog

Diabetes (New York, N.Y.), 2014-11, Vol.63 (11), p.3946-3954

2014

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Peripherally delivered hepatopreferential insulin analog insulin‐406 mimics the hypoglycaemia‐sparing effect of portal vein human insulin infusion in dogs

Diabetes, obesity & metabolism, 2019-10, Vol.21 (10), p.2294-2304

2019

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Intracellular Retention of Newly Synthesized Insulin in Yeast Is Caused by Endoproteolytic Processing in the Golgi Complex

The Journal of cell biology, 2001-06, Vol.153 (6), p.1187-1197

2001

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Expression, Receptor Binding, and Biophysical Characterization of Guinea Pig Insulin desB30: A Monomeric Insulin Variant

Chembiochem : a European journal of chemical biology, 2015-04, Vol.16 (6), p.954-958

2015

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The road to the first, fully active and more stable human insulin variant with an additional disulfide bond

Journal of peptide science, 2015-11, Vol.21 (11), p.797-806

2015

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Identification of Anchor Points for Chemical Modification of a Small Cysteine-Rich Protein by Using a Cysteine Scan

Chembiochem : a European journal of chemical biology, 2011-11, Vol.12 (16), p.2448-2455

2011

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Inside Cover: Identification of Anchor Points for Chemical Modification of a Small Cysteine-Rich Protein by Using a Cysteine Scan (ChemBioChem 16/2011)

Chembiochem : a European journal of chemical biology, 2011-11, Vol.12 (16), p.2378-2378

2011

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Human-human hybridomas and human monoclonal antibodies obtained by fusion of lymph node lymphocytes from breast cancer patients

Cancer research (Chicago, Ill.), 1988-06, Vol.48 (11), p.3208-3214

1988

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Monoclonal Antibodies Reactive with Components in Serum-Free Conditioned Medium from a Human Breast Cancer Cell Line (MCF-7)

Tumor biology, 1989, Vol.10 (4), p.190-201

1989

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Changing climate both increases and decreases European river floods

Nature (London), 2019-09, Vol.573 (7772), p.108-111

2019

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Changing climate shifts timing of European floods

Science (American Association for the Advancement of Science), 2017-08, Vol.357 (6351), p.588-590

2017

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Medical Therapies for Heart Failure With Preserved Ejection Fraction

Hypertension (Dallas, Tex. 1979), 2020-01, Vol.75 (1), p.23-32

2020

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Microbial community assembly and evolution in subseafloor sediment

Proceedings of the National Academy of Sciences - PNAS, 2017-03, Vol.114 (11), p.2940-2945

2017

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BedMachine v3: Complete Bed Topography and Ocean Bathymetry Mapping of Greenland From Multibeam Echo Sounding Combined With Mass Conservation

Geophysical research letters, 2017-11, Vol.44 (21), p.11,051-11,061

2017

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Comprehensive efforts to increase adherence to statin therapy

European heart journal, 2017-08, Vol.38 (32), p.2473-2479

2017

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2018 ESC/ESH Guidelines for the management of arterial hypertension

European heart journal, 2018-09, Vol.39 (33), p.3021-3104

2018

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Mass balance of the Greenland Ice Sheet from 1992 to 2018

Nature (London), 2020-03, Vol.579 (7798), p.233-239

2020

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Expert consensus document on the management of hyperkalaemia in patients with cardiovascular disease treated with renin angiotensin aldosterone system inhibitors: coordinated by the Working Group on Cardiovascular Pharmacotherapy of the European Society of Cardiology

European heart journal. Cardiovascular pharmacotherapy, 2018-07, Vol.4 (3), p.180-188

2018

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Enhanced disulphide bond stability contributes to the once-weekly profile of insulin icodec

Molecular Engineering of Insulin Icodec, the First Acylated Insulin Analog for Once-Weekly Administration in Humans

Predicting human half-life for insulin analogs: An inter-drug approach

Engineering of Orally Available, Ultralong-Acting Insulin Analogues: Discovery of OI338 and OI320

Molecular Engineering of Efficacious Mono-Valent Ultra-Long Acting Two-Chain Insulin-Fc Conjugates

Changes in glucose and fat metabolism in response to the administration of a hepato-preferential insulin analog

Peripherally delivered hepatopreferential insulin analog insulin‐406 mimics the hypoglycaemia‐sparing effect of portal vein human insulin infusion in dogs

Intracellular Retention of Newly Synthesized Insulin in Yeast Is Caused by Endoproteolytic Processing in the Golgi Complex

Expression, Receptor Binding, and Biophysical Characterization of Guinea Pig Insulin desB30: A Monomeric Insulin Variant

The road to the first, fully active and more stable human insulin variant with an additional disulfide bond

Identification of Anchor Points for Chemical Modification of a Small Cysteine-Rich Protein by Using a Cysteine Scan

Inside Cover: Identification of Anchor Points for Chemical Modification of a Small Cysteine-Rich Protein by Using a Cysteine Scan (ChemBioChem 16/2011)

Human-human hybridomas and human monoclonal antibodies obtained by fusion of lymph node lymphocytes from breast cancer patients

Monoclonal Antibodies Reactive with Components in Serum-Free Conditioned Medium from a Human Breast Cancer Cell Line (MCF-7)

Changing climate both increases and decreases European river floods

Changing climate shifts timing of European floods

Medical Therapies for Heart Failure With Preserved Ejection Fraction

Microbial community assembly and evolution in subseafloor sediment

2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management: The Joint Task Force on non-cardiac surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA)

BedMachine v3: Complete Bed Topography and Ocean Bathymetry Mapping of Greenland From Multibeam Echo Sounding Combined With Mass Conservation

Comprehensive efforts to increase adherence to statin therapy

2018 ESC/ESH Guidelines for the management of arterial hypertension

Mass balance of the Greenland Ice Sheet from 1992 to 2018

Expert consensus document on the management of hyperkalaemia in patients with cardiovascular disease treated with renin angiotensin aldosterone system inhibitors: coordinated by the Working Group on Cardiovascular Pharmacotherapy of the European Society of Cardiology

2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management: The Joint Task Force on non-cardiac surgery: cardiovascular assessment and management of the European Society of Cardiology (ESC) and the European Society of Anaesthesiology (ESA)

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