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Comprehensive Cardiac Safety Assessment using hiPS-cardiomyocytes (Consortium for Safety Assessment using Human iPS Cells: CSAHi)

Current pharmaceutical biotechnology, 2020-01, Vol.21 (9), p.829-841

2020

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Electrophysiological evaluation of pentamidine and 17-AAG in human stem cell-derived cardiomyocytes for safety assessment

European journal of pharmacology, 2019-01, Vol.842, p.221-230

2019

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On-chip spatiotemporal electrophysiological analysis of human stem cell derived cardiomyocytes enables quantitative assessment of proarrhythmia in drug development

Scientific reports, 2018-09, Vol.8 (1), p.14536-13, Article 14536

2018

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On-chip in vitro cell-network pre-clinical cardiac toxicity using spatiotemporal human cardiomyocyte measurement on a chip

Scientific reports, 2014-04, Vol.4 (1), p.4670, Article 4670

2014

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Estimation of Glomerular Filtration Rate in Cynomolgus Monkeys (Macaca fascicularis)

Journal of Veterinary Medical Science, 2014, Vol.76(10), pp.1423-1426

2014

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In vivo experimental approach for the risk assessment of fluoroquinolone antibacterial agents-induced long QT syndrome

European journal of pharmacology, 2004-02, Vol.486 (2), p.189-200

2004

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Anticonvulsant Properties of the Novel Nootropic Agent Nefiracetam in Seizure Models of Mice and Rats

Epilepsia (Copenhagen), 2005-06, Vol.46 (6), p.811-818

2005

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Availability of intracellular Ca2 + imaging using iPS-induced cardiomyocytes as a new cardiac toxicity assessment

Journal of pharmacological and toxicological methods, 2015-09, Vol.75, p.199-199

2015

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Bayesian approach enabled objective comparison of multiple human iPSC-derived Cardiomyocytes' Proarrhythmia sensitivities

Journal of pharmacological and toxicological methods, 2024-07, Vol.128, p.107531, Article 107531

2024

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Pre-clinical QT Risk Assessment in Pharmaceutical Companies - Issues of Current QT Risk Assessment

Biomolecules & Therapeutics, 2009, 17(1), , pp.1-11

2009

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Identification of cardiac liability in drug discovery using automated patch clamp: experimental and technical considerations for high throughput recordings of NaV1.5 and hERG

Biophysical journal, 2022-02, Vol.121 (3), p.503a-503a

2022

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Comprehensive in vitro cardiac safety assessment using human stem cell technology: Overview of CSAHi HEART initiative

Journal of pharmacological and toxicological methods, 2017-01, Vol.83, p.42-54

2017

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Acute Hypokalemia May Not Be an Effective Way to Sensitize the In Situ Canine Heart for Sparfloxacin-Induced Long QT Syndrome

Journal of Pharmacological Sciences, 2006, Vol.100(1), pp.88-92

2006

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Current comprehensive in vitro cardiac safety assessment using human stem cell technology (CSAHi: HEART initiative) –The second stage: Ca transient platform

Journal of pharmacological and toxicological methods, 2018-09, Vol.93, p.146-147

2018

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Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment

Journal of pharmacological and toxicological methods, 2020-09, Vol.105, p.106884-106884, Article 106884

2020

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Comparison of sensitivity of surrogate markers of drug-induced torsades de pointes in canine hearts

European journal of pharmacology, 2004-10, Vol.502 (1), p.117-122

2004

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Does alloxan-induced diabetes enhance the susceptibility of the methoxamine-sensitized rabbit model of TdP to quinolone antibiotics?

Journal of pharmacological and toxicological methods, 2009-09, Vol.60 (2), p.250-250

Takasuna, Kiyoshi

2009

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Discovery of DS-1971a, a Potent, Selective NaV1.7 Inhibitor

Journal of medicinal chemistry, 2020-09, Vol.63 (18), p.10204-10220

2020

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Effects of Nefiracetam, a Novel Pyrrolidone‐type Nootropic Agent, on the Amygdala‐kindled Seizures in Rats

Epilepsia (Copenhagen), 2005-10, Vol.46 (10), p.1561-1568

2005

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Comprehensive in vitro cardiac safety assessment using human stem cell technology (CSAHi–The second stage) –Ca2+ transient platform

Journal of pharmacological and toxicological methods, 2019-09, Vol.99, p.106595, Article 106595

2019

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Reliable identification of heart disease in drug discovery using automated patch clamps: Benchmarking best practices and calibration criteria for improved proarrhythmic assessment

Journal of pharmacological and toxicological methods, 2021-09, Vol.111, p.106963, Article 106963

2021

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Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment

Journal of pharmacological and toxicological methods, 2021-11, Vol.112, p.107125-107125, Article 107125

2021

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N -Aryl Indoles as a Novel Class of Potent Na V 1.7 Inhibitors

ACS medicinal chemistry letters, 2023-06, Vol.14 (6), p.788-793

2023

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N‑Aryl Indoles as a Novel Class of Potent NaV1.7 Inhibitors

ACS medicinal chemistry letters, 2023-06, Vol.14 (6), p.788-793

2023

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Discovery of DS-1971a, a Potent, Selective Na V 1.7 Inhibitor

Journal of medicinal chemistry, 2020-09, Vol.63 (18), p.10204-10220

2020

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Comprehensive Cardiac Safety Assessment using hiPS-cardiomyocytes (Consortium for Safety Assessment using Human iPS Cells: CSAHi)

Electrophysiological evaluation of pentamidine and 17-AAG in human stem cell-derived cardiomyocytes for safety assessment

On-chip spatiotemporal electrophysiological analysis of human stem cell derived cardiomyocytes enables quantitative assessment of proarrhythmia in drug development

On-chip in vitro cell-network pre-clinical cardiac toxicity using spatiotemporal human cardiomyocyte measurement on a chip

Estimation of Glomerular Filtration Rate in Cynomolgus Monkeys (Macaca fascicularis)

In vivo experimental approach for the risk assessment of fluoroquinolone antibacterial agents-induced long QT syndrome

Anticonvulsant Properties of the Novel Nootropic Agent Nefiracetam in Seizure Models of Mice and Rats

Availability of intracellular Ca2 + imaging using iPS-induced cardiomyocytes as a new cardiac toxicity assessment

Bayesian approach enabled objective comparison of multiple human iPSC-derived Cardiomyocytes' Proarrhythmia sensitivities

Pre-clinical QT Risk Assessment in Pharmaceutical Companies - Issues of Current QT Risk Assessment

Identification of cardiac liability in drug discovery using automated patch clamp: experimental and technical considerations for high throughput recordings of NaV1.5 and hERG

Comprehensive in vitro cardiac safety assessment using human stem cell technology: Overview of CSAHi HEART initiative

Acute Hypokalemia May Not Be an Effective Way to Sensitize the In Situ Canine Heart for Sparfloxacin-Induced Long QT Syndrome

Current comprehensive in vitro cardiac safety assessment using human stem cell technology (CSAHi: HEART initiative) –The second stage: Ca transient platform

Reliable identification of cardiac liability in drug discovery using automated patch clamp: Benchmarking best practices and calibration standards for improved proarrhythmic assessment

Comparison of sensitivity of surrogate markers of drug-induced torsades de pointes in canine hearts

Does alloxan-induced diabetes enhance the susceptibility of the methoxamine-sensitized rabbit model of TdP to quinolone antibiotics?

Discovery of DS-1971a, a Potent, Selective NaV1.7 Inhibitor

Effects of Nefiracetam, a Novel Pyrrolidone‐type Nootropic Agent, on the Amygdala‐kindled Seizures in Rats

Comprehensive in vitro cardiac safety assessment using human stem cell technology (CSAHi–The second stage) –Ca2+ transient platform

Reliable identification of heart disease in drug discovery using automated patch clamps: Benchmarking best practices and calibration criteria for improved proarrhythmic assessment

Reliable identification of cardiac conduction abnormalities in drug discovery using automated patch clamp II: Best practices for Nav1.5 peak current in a high throughput screening environment

N -Aryl Indoles as a Novel Class of Potent Na V 1.7 Inhibitors

N‑Aryl Indoles as a Novel Class of Potent NaV1.7 Inhibitors

Discovery of DS-1971a, a Potent, Selective Na V 1.7 Inhibitor

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