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Macrophage-based cell therapies: The long and winding road

Journal of controlled release, 2016-10, Vol.240, p.527-540

2016

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Fusion of a short peptide that binds immunoglobulin G to a recombinant protein substantially increases its plasma half-life in mice

PloS one, 2014-07, Vol.9 (7), p.e102566

2014

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Chemoenzymatic Synthesis of Oligohyaluronan–Lipid Conjugates

Bioconjugate chemistry, 2014-04, Vol.25 (4), p.718-723

2014

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Delivery of Lipid Micelles into Infarcted Myocardium Using a Lipid-Linked Matrix Metalloproteinase Targeting Peptide

Molecular pharmaceutics, 2015-04, Vol.12 (4), p.1150-1157

2015

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Bempegaldesleukin (BEMPEG; NKTR‐214) efficacy as a single agent and in combination with checkpoint‐inhibitor therapy in mouse models of osteosarcoma

International journal of cancer, 2021-04, Vol.148 (8), p.1928-1937

2021

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Activating PER repressor through a DBT-directed phosphorylation switch

PLoS biology, 2008-07, Vol.6 (7), p.e183-e183

2008

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Posttranscriptional and Posttranslational Regulation of Clock Genes

Journal of biological rhythms, 2004-10, Vol.19 (5), p.361-373

2004

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Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice

Molecular therapy. Methods & clinical development, 2017-12, Vol.7 (C), p.60-73

2017

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Dact1 Is a Postsynaptic Protein Required for Dendrite, Spine, and Excitatory Synapse Development in the Mouse Forebrain

The Journal of neuroscience, 2010-03, Vol.30 (12), p.4362-4368

2010

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Three Dact gene family members are expressed during embryonic development and in the adult brains of mice

Developmental dynamics, 2006-09, Vol.235 (9), p.2620-2630

2006

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The effect of polymer backbone chemistry on the induction of the accelerated blood clearance in polymer modified liposomes

Journal of controlled release, 2015-09, Vol.213, p.1-9

2015

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NKTR-255, a novel polymer-conjugated rhIL-15 with potent antitumor efficacy

Journal for immunotherapy of cancer, 2021-05, Vol.9 (5), p.e002024

2021

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Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak

Nature genetics, 2009-09, Vol.41 (9), p.977-985

2009

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Improving the distribution of Doxil® in the tumor matrix by depletion of tumor hyaluronan

Journal of controlled release, 2014-10, Vol.191, p.105-114

2014

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Glucose Sensor O-GlcNAcylation Coordinates with Phosphorylation to Regulate Circadian Clock

Cell metabolism, 2013-02, Vol.17 (2), p.291-302

2013

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568. Characterization of Iduronidase-Expressing Monocyte Progenitor Cells for a Cell Based Therapy for Hurler Syndrome

Molecular therapy, 2015-05, Vol.23, p.S226-S227

2015

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Dact1–3 mRNAs exhibit distinct expression domains during tooth development

Gene Expression Patterns, 2010-02, Vol.10 (2), p.140-143

2010

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DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/β-catenin signaling

Molecular psychiatry, 2018-02, Vol.23 (2), p.467-475

2018

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Combining bempegaldesleukin (CD122-preferential IL-2 pathway agonist) and NKTR-262 (TLR7/8 agonist) improves systemic antitumor CD8+ T cell cytotoxicity over BEMPEG+RT

Journal for immunotherapy of cancer, 2022-04, Vol.10 (4), p.e004218

2022

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NKTR-255, a Polymer-Conjugated IL-15 Enhances Antibody-Dependent Cellular Cytotoxicity Mediated By NK Cells in a B Cell Lymphoma Model

Blood, 2019-11, Vol.134 (Supplement_1), p.5302-5302

2019

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Abstract 3265: NKTR-255, a polymer-conjugated IL-15 enhances anti-tumor NK cell responses and synergizes with monoclonal antibodies to provide long-term survival in human lymphoma model

Cancer research (Chicago, Ill.), 2019-07, Vol.79 (13_Supplement), p.3265-3265

2019

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451 Combining Bempegaldesleukin (CD122-preferential IL-2 pathway agonist) and NKTR-262 (TLR7/8 agonist) pairs local innate activation with systemic CD8+ T cell expansion to enhance anti-tumor immunity

Journal for immunotherapy of cancer, 2020-11, Vol.8 (Suppl 3), p.A274-A274

2020

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DACT3 Is an Epigenetic Regulator of Wnt/β-Catenin Signaling in Colorectal Cancer and Is a Therapeutic Target of Histone Modifications

Cancer cell, 2008-06, Vol.13 (6), p.529-541

2008

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All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases

BMC biochemistry, 2011-06, Vol.12 (1), p.33-33, Article 33

2011

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229. Engineered Macrophage-Based Cell Therapy for Cancer Treatment

Molecular therapy, 2015-05, Vol.23, p.S90-S90

2015

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Macrophage-based cell therapies: The long and winding road

Fusion of a short peptide that binds immunoglobulin G to a recombinant protein substantially increases its plasma half-life in mice

Chemoenzymatic Synthesis of Oligohyaluronan–Lipid Conjugates

Delivery of Lipid Micelles into Infarcted Myocardium Using a Lipid-Linked Matrix Metalloproteinase Targeting Peptide

Bempegaldesleukin (BEMPEG; NKTR‐214) efficacy as a single agent and in combination with checkpoint‐inhibitor therapy in mouse models of osteosarcoma

Activating PER repressor through a DBT-directed phosphorylation switch

Posttranscriptional and Posttranslational Regulation of Clock Genes

Clodronate Improves Survival of Transplanted Hoxb8 Myeloid Progenitors with Constitutively Active GMCSFR in Immunocompetent Mice

Dact1 Is a Postsynaptic Protein Required for Dendrite, Spine, and Excitatory Synapse Development in the Mouse Forebrain

Three Dact gene family members are expressed during embryonic development and in the adult brains of mice

The effect of polymer backbone chemistry on the induction of the accelerated blood clearance in polymer modified liposomes

NKTR-255, a novel polymer-conjugated rhIL-15 with potent antitumor efficacy

Posterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streak

Improving the distribution of Doxil® in the tumor matrix by depletion of tumor hyaluronan

Glucose Sensor O-GlcNAcylation Coordinates with Phosphorylation to Regulate Circadian Clock

568. Characterization of Iduronidase-Expressing Monocyte Progenitor Cells for a Cell Based Therapy for Hurler Syndrome

Dact1–3 mRNAs exhibit distinct expression domains during tooth development

DIXDC1 contributes to psychiatric susceptibility by regulating dendritic spine and glutamatergic synapse density via GSK3 and Wnt/β-catenin signaling

Combining bempegaldesleukin (CD122-preferential IL-2 pathway agonist) and NKTR-262 (TLR7/8 agonist) improves systemic antitumor CD8+ T cell cytotoxicity over BEMPEG+RT

NKTR-255, a Polymer-Conjugated IL-15 Enhances Antibody-Dependent Cellular Cytotoxicity Mediated By NK Cells in a B Cell Lymphoma Model

Abstract 3265: NKTR-255, a polymer-conjugated IL-15 enhances anti-tumor NK cell responses and synergizes with monoclonal antibodies to provide long-term survival in human lymphoma model

451 Combining Bempegaldesleukin (CD122-preferential IL-2 pathway agonist) and NKTR-262 (TLR7/8 agonist) pairs local innate activation with systemic CD8+ T cell expansion to enhance anti-tumor immunity

DACT3 Is an Epigenetic Regulator of Wnt/β-Catenin Signaling in Colorectal Cancer and Is a Therapeutic Target of Histone Modifications

All Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinases

229. Engineered Macrophage-Based Cell Therapy for Cancer Treatment

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