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SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase

Proceedings of the National Academy of Sciences - PNAS, 2019-09, Vol.116 (38), p.18808-18814

2019

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Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs

Angewandte Chemie International Edition, 2020-07, Vol.59 (30), p.12460-12469

International ed. in English, 2020

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Discovery of small-molecule enzyme activators by activity-based protein profiling

Nature chemical biology, 2020-09, Vol.16 (9), p.997-1005

2020

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Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria

Nature microbiology, 2020-01, Vol.5 (1), p.56-66

2020

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Occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order Brassicales

PloS one, 2017-05, Vol.12 (5), p.e0176571-e0176571

2017

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The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria

Marine drugs, 2022-05, Vol.20 (6), p.373

2022

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Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia

ACS central science, 2021-05, Vol.7 (5), p.815-830

2021

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Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo

PloS one, 2015-02, Vol.10 (2), p.e0117438-e0117438

2015

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Synthetic Elaboration of Native DNA by RASS (SENDR)

ACS central science, 2020-10, Vol.6 (10), p.1789-1799

2020

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Correction to “Synthetic Elaboration of Native DNA by RASS (SENDR)”

ACS central science, 2020-11, Vol.6 (11), p.2117-2117

2020

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Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry

Journal of the American Chemical Society, 2020-06, Vol.142 (25), p.10899-10904

2020

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Lipoprotein Signal Peptidase Inhibitors with Antibiotic Properties Identified through Design of a Robust In Vitro HT Platform

Cell chemical biology, 2018-03, Vol.25 (3), p.301-308.e12

2018

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Probing substrate recognition of bacterial lipoprotein signal peptidase using FRET reporters

FEBS letters, 2018-07, Vol.592 (13), p.2289-2296

2018

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Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors

Proceedings of the National Academy of Sciences - PNAS, 2022-09, Vol.119 (37), p.e2208540119

2022

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Metabolomics activity screening of T cell-induced colitis reveals anti-inflammatory metabolites

Science signaling, 2021-09, Vol.14 (702), p.eabf6584

2021

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A photoaffinity probe that targets folate-binding proteins

Bioorganic & medicinal chemistry letters, 2021-05, Vol.40, p.127903-127903, Article 127903

2021

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SuFEx-based chemical diversification for the systematic discovery of CRBN molecular glues

Bioorganic & medicinal chemistry, 2024-04, Vol.104, p.117699-117699, Article 117699

2024

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An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen

Proceedings of the National Academy of Sciences - PNAS, 2020-08, Vol.117 (31), p.18431-18438

2020

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PROTAC-Mediated Selective Degradation of Cytosolic Soluble Epoxide Hydrolase Enhances ER Stress Reduction

ACS chemical biology, 2023-04, Vol.18 (4), p.884-896

2023

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Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry

Proceedings of the National Academy of Sciences - PNAS, 2024-05, Vol.121 (22), p.e2310677121

2024

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SuFEx-enabled high-throughput medicinal chemistry

Journal of the American Chemical Society, 2020-06, Vol.142 (25), p.10899-10904

2020

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Insights into the Interaction Landscape of the EVH1 Domain of Mena

Biochemistry (Easton), 2024-09, Vol.63 (17), p.2183-2195

2024

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In Vivo -Active Soluble Epoxide Hydrolase-Targeting PROTACs with Improved Potency and Stability

ACS medicinal chemistry letters, 2024-10

2024

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An Irreversible Inhibitor to Probe the Role of Streptococcus pyogenes Cysteine Protease SpeB in Evasion of Host Complement Defenses

ACS chemical biology, 2020-08, Vol.15 (8), p.2060-2069

2020

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Nanobody-based binding assay for the discovery of potent inhibitors of CFTR inhibitory factor (Cif)

Analytica chimica acta, 2019-05, Vol.1057, p.106-113

2019

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SuFEx-enabled, agnostic discovery of covalent inhibitors of human neutrophil elastase

Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs

Discovery of small-molecule enzyme activators by activity-based protein profiling

Genetic basis for the cooperative bioactivation of plant lignans by Eggerthella lenta and other human gut bacteria

Occurrence of urea-based soluble epoxide hydrolase inhibitors from the plants in the order Brassicales

The Development of the Bengamides as New Antibiotics against Drug-Resistant Bacteria

Chemical Inhibition of ENL/AF9 YEATS Domains in Acute Leukemia

Potent natural soluble epoxide hydrolase inhibitors from Pentadiplandra brazzeana baillon: synthesis, quantification, and measurement of biological activities in vitro and in vivo

Synthetic Elaboration of Native DNA by RASS (SENDR)

Correction to “Synthetic Elaboration of Native DNA by RASS (SENDR)”

Sulfur(VI) Fluoride Exchange (SuFEx)-Enabled High-Throughput Medicinal Chemistry

Lipoprotein Signal Peptidase Inhibitors with Antibiotic Properties Identified through Design of a Robust In Vitro HT Platform

Probing substrate recognition of bacterial lipoprotein signal peptidase using FRET reporters

Diversity oriented clicking delivers β-substituted alkenyl sulfonyl fluorides as covalent human neutrophil elastase inhibitors

Metabolomics activity screening of T cell-induced colitis reveals anti-inflammatory metabolites

A photoaffinity probe that targets folate-binding proteins

SuFEx-based chemical diversification for the systematic discovery of CRBN molecular glues

An influenza A hemagglutinin small-molecule fusion inhibitor identified by a new high-throughput fluorescence polarization screen

PROTAC-Mediated Selective Degradation of Cytosolic Soluble Epoxide Hydrolase Enhances ER Stress Reduction

Ultrapotent influenza hemagglutinin fusion inhibitors developed through SuFEx-enabled high-throughput medicinal chemistry

SuFEx-enabled high-throughput medicinal chemistry

Insights into the Interaction Landscape of the EVH1 Domain of Mena

In Vivo -Active Soluble Epoxide Hydrolase-Targeting PROTACs with Improved Potency and Stability

An Irreversible Inhibitor to Probe the Role of Streptococcus pyogenes Cysteine Protease SpeB in Evasion of Host Complement Defenses

Nanobody-based binding assay for the discovery of potent inhibitors of CFTR inhibitory factor (Cif)

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