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J147 Reduces tPA-Induced Brain Hemorrhage in Acute Experimental Stroke in Rats

Frontiers in neurology, 2022-03, Vol.13, p.821082

2022

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Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

Nature (London), 1995-12, Vol.378 (6557), p.641-644

1995

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Rapid automated molecular replacement by evolutionary search

Acta crystallographica. Section D, Biological crystallography., 1999-02, Vol.55 (2), p.484-491

1999

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Intrinsically disordered protein

Journal of molecular graphics & modelling, 2001-01, Vol.19 (1), p.26-59

2001

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Crystal Structure of Human ABAD/HSD10 with a Bound Inhibitor: Implications for Design of Alzheimer's Disease Therapeutics

Journal of molecular biology, 2004-09, Vol.342 (3), p.943-952

2004

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Structure of hepatitis C virus IRES subdomain IIa

Acta crystallographica. Section D, Biological crystallography., 2008-04, Vol.64 (4), p.436-443

2008

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Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2009-11, Vol.19 (22), p.6404-6412

2009

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1' -dioxo-1' 4'-dihydro-1 λ6-benzoll 1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: Exploration of 7'-substitution of benzothiadiazine

Bioorganic & medicinal chemistry letters, 2008-02, Vol.18 (4), p.1413-1418

2008

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Pyrrolo[1,2- b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry, 2008-06, Vol.18 (12), p.3616-3621

2008

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1' ,4'-dihydro-1 λ6-benzoll[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2-and 6-pyridazinone substituents

Bioorganic & medicinal chemistry letters, 2008-02, Vol.18 (4), p.1419-1424

2008

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Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'λ6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5. Exploration of pyridazinones containing 6-amino-substituents

Bioorganic & medicinal chemistry letters, 2008-10, Vol.18 (20), p.5635-5639

2008

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Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[ b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase

Bioorganic & medicinal chemistry, 2008-07, Vol.18 (14), p.4181-4185

2008

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5,5'- and 6,6'-Dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2009-11, Vol.19 (21), p.6047-6052

2009

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Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

Cell, 1990-11, Vol.63 (3), p.579-590

1990

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Hexahydro-pyrrolo-and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry, 2008-09, Vol.18 (18), p.5002-5005

2008

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4-(1,1-Dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase

Bioorganic & medicinal chemistry letters, 2008-08, Vol.18 (16), p.4628-4632

2008

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Structural studies of the engrailed homeodomain

Protein science, 1994-10, Vol.3 (10), p.1779-1787

1994

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Refined crystal structure of ferredoxin II from Desulfovibrio gigas at 1·7 Å

Journal of molecular biology, 1991-06, Vol.219 (4), p.693-715

1991

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Interaction of a Novel GDP Exchange Inhibitor with the Ras Protein

Biochemistry (Easton), 1998-11, Vol.37 (45), p.15631-15637

1998

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Structure-Based Design of Novel, Urea-Containing FKBP12 Inhibitors

Journal of medicinal chemistry, 1996-04, Vol.39 (9), p.1872-1884

1996

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Structure-based design of novel calcineurin (PP2B) inhibitors

Bioorganic & medicinal chemistry letters, 1997-04, Vol.7 (8), p.1007-1012

1997

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Structure of the 3 iron-4 sulfur cluster in Desulfovibrio gigas ferredoxin II

Journal of the American Chemical Society, 1988-12, Vol.110 (26), p.8721-8723

1988

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Molecular replacement by evolutionary search

Acta crystallographica. Section D, Biological crystallography., 2001-10, Vol.57 (10), p.1474-1479

2001

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J147 Reduces tPA-Induced Brain Hemorrhage in Acute Experimental Stroke in Rats

Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

Rapid automated molecular replacement by evolutionary search

Intrinsically disordered protein

Crystal Structure of Human ABAD/HSD10 with a Bound Inhibitor: Implications for Design of Alzheimer's Disease Therapeutics

Structure of hepatitis C virus IRES subdomain IIa

Discovery of tricyclic 5,6-dihydro-1H-pyridin-2-ones as novel, potent, and orally bioavailable inhibitors of HCV NS5B polymerase

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1' -dioxo-1' 4'-dihydro-1 λ6-benzoll 1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 1: Exploration of 7'-substitution of benzothiadiazine

Pyrrolo[1,2- b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'lambda(6)-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7'-substituents and initial pharmacokinetic assessments

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1' ,4'-dihydro-1 λ6-benzoll[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 2: Variation of the 2-and 6-pyridazinone substituents

Novel HCV NS5B polymerase inhibitors derived from 4-(1',1'-dioxo-1',4'-dihydro-1'λ6-benzo[1',2',4']thiadiazin-3'-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 5. Exploration of pyridazinones containing 6-amino-substituents

Structure-based design, synthesis, and biological evaluation of 1,1-dioxoisothiazole and benzo[ b]thiophene-1,1-dioxide derivatives as novel inhibitors of hepatitis C virus NS5B polymerase

5,5'- and 6,6'-Dialkyl-5,6-dihydro-1H-pyridin-2-ones as potent inhibitors of HCV NS5B polymerase

Crystal structure of an engrailed homeodomain-DNA complex at 2.8 Å resolution: A framework for understanding homeodomain-DNA interactions

Hexahydro-pyrrolo-and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase

4-(1,1-Dioxo-1,4-dihydro-1λ6-benzo[1,4]thiazin-3-yl)-5-hydroxy-2H-pyridazin-3-ones as potent inhibitors of HCV NS5B polymerase

Structural studies of the engrailed homeodomain

Refined crystal structure of ferredoxin II from Desulfovibrio gigas at 1·7 Å

Interaction of a Novel GDP Exchange Inhibitor with the Ras Protein

Structure-Based Design of Novel, Urea-Containing FKBP12 Inhibitors

Structure-based design of novel calcineurin (PP2B) inhibitors

Structure of the 3 iron-4 sulfur cluster in Desulfovibrio gigas ferredoxin II

Novel HCV NS5B polymerase inhibitors derived from 4-(1′,1′-dioxo-1′,4′-dihydro-1′λ6-benzo[1′,2′,4′]thiadiazin-3′-yl)-5-hydroxy-2H-pyridazin-3-ones. Part 3: Further optimization of the 2-, 6-, and 7′-substituents and initial pharmacokinetic assessments

Molecular replacement by evolutionary search

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