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Development of ImmTOR Tolerogenic Nanoparticles for the Mitigation of Anti-drug Antibodies

Frontiers in immunology, 2020-05, Vol.11, p.969

Kishimoto, Takashi Kei

2020

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Nanoparticles for the Induction of Antigen-Specific Immunological Tolerance

Frontiers in immunology, 2018-02, Vol.9, p.230-230

2018

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Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration

Nature communications, 2018-10, Vol.9 (1), p.4098-13, Article 4098

2018

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Tolerogenic nanoparticles mitigate the formation of anti-drug antibodies against pegylated uricase in patients with hyperuricemia

Nature communications, 2022-01, Vol.13 (1), p.272-272, Article 272

2022

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Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance

Proceedings of the National Academy of Sciences - PNAS, 2015-01, Vol.112 (2), p.E156-E165

2015

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M402, a novel heparan sulfate mimetic, targets multiple pathways implicated in tumor progression and metastasis

PloS one, 2011-06, Vol.6 (6), p.e21106-e21106

2011

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Non-invasive detection of a small number of bioluminescent cancer cells in vivo

PloS one, 2010-02, Vol.5 (2), p.e9364-e9364

2010

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Enhancement of the Tolerogenic Phenotype in the Liver by ImmTOR Nanoparticles

Frontiers in immunology, 2021-05, Vol.12, p.637469-637469

2021

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Outbreak of Adverse Reactions Associated with Contaminated Heparin

The New England journal of medicine, 2008-12, Vol.359 (25), p.2674-2684

2008

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Synthetic vaccine particles for durable cytolytic T lymphocyte responses and anti-tumor immunotherapy

PloS one, 2018-06, Vol.13 (6), p.e0197694-e0197694

2018

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Addressing high dose AAV toxicity - 'one and done' or 'slower and lower'?

Expert opinion on biological therapy, 2022-09, Vol.22 (9), p.1067-1071

2022

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ImmTOR nanoparticles enhance AAV transgene expression after initial and repeat dosing in a mouse model of methylmalonic acidemia

Molecular therapy. Methods & clinical development, 2021-09, Vol.22, p.279-292

2021

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Long-term correction of ornithine transcarbamylase deficiency in Spf-Ash mice with a translationally optimized AAV vector

Molecular therapy. Methods & clinical development, 2021-03, Vol.20, p.169-180

2021

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Diverse Cell Surface Protein Ectodomains Are Shed by a System Sensitive to Metalloprotease Inhibitors (∗)

The Journal of biological chemistry, 1996-05, Vol.271 (19), p.11376-11382

1996

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M118--a rationally engineered low-molecular-weight heparin designed specifically for the treatment of acute coronary syndromes

Thrombosis and haemostasis, 2009-11, Vol.102 (5), p.900-906

2009

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ImmTORTM to amplify the efficacy and reduce immunogenicity of biologics

Emerging topics in life sciences, 2021-11, Vol.5 (5), p.597-600

2021

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Tolerogenic nanoparticles restore the antitumor activity of recombinant immunotoxins by mitigating immunogenicity

Proceedings of the National Academy of Sciences - PNAS, 2018-01, Vol.115 (4), p.E733-E742

2018

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Neutrophil Mac-1 and MEL-14 Adhesion Proteins Inversely Regulated by Chemotactic Factors

Science (American Association for the Advancement of Science), 1989-09, Vol.245 (4923), p.1238-1241

1989

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Abstract 72: Induction of immune tolerance to recombinant immunotoxin LMB-100 using synthetic vaccine particles encapsulating rapamycin

Cancer research (Chicago, Ill.), 2017-07, Vol.77 (13_Supplement), p.72-72

2017

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Immune tolerance to recombinant immunotoxin LMB-100 using synthetic vaccine particles encapsulating rapamycin

The Journal of immunology (1950), 2017-05, Vol.198 (1_Supplement), p.154-154.2

2017

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Identification of N-terminal Residues on P-selectin Glycoprotein Ligand-1 Required for Binding to P-selectin

The Journal of biological chemistry, 1998-03, Vol.273 (12), p.7078-7087

1998

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Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System

The New England journal of medicine, 2008-06, Vol.358 (23), p.2457-2467

2008

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Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease

Journal of autoimmunity, 2023-11, Vol.140, p.103125-103125, Article 103125

2023

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Generation of a universal CD4 memory T cell recall peptide effective in humans, mice and non-human primates

Vaccine, 2014-05, Vol.32 (24), p.2896-2903

2014

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Development of ImmTOR Tolerogenic Nanoparticles for the Mitigation of Anti-drug Antibodies

Nanoparticles for the Induction of Antigen-Specific Immunological Tolerance

Antigen-selective modulation of AAV immunogenicity with tolerogenic rapamycin nanoparticles enables successful vector re-administration

Tolerogenic nanoparticles mitigate the formation of anti-drug antibodies against pegylated uricase in patients with hyperuricemia

Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance

M402, a novel heparan sulfate mimetic, targets multiple pathways implicated in tumor progression and metastasis

Non-invasive detection of a small number of bioluminescent cancer cells in vivo

Enhancement of the Tolerogenic Phenotype in the Liver by ImmTOR Nanoparticles

Outbreak of Adverse Reactions Associated with Contaminated Heparin

Synthetic vaccine particles for durable cytolytic T lymphocyte responses and anti-tumor immunotherapy

Addressing high dose AAV toxicity - 'one and done' or 'slower and lower'?

ImmTOR nanoparticles enhance AAV transgene expression after initial and repeat dosing in a mouse model of methylmalonic acidemia

Long-term correction of ornithine transcarbamylase deficiency in Spf-Ash mice with a translationally optimized AAV vector

Diverse Cell Surface Protein Ectodomains Are Shed by a System Sensitive to Metalloprotease Inhibitors (∗)

M118--a rationally engineered low-molecular-weight heparin designed specifically for the treatment of acute coronary syndromes

ImmTORTM to amplify the efficacy and reduce immunogenicity of biologics

Tolerogenic nanoparticles restore the antitumor activity of recombinant immunotoxins by mitigating immunogenicity

Neutrophil Mac-1 and MEL-14 Adhesion Proteins Inversely Regulated by Chemotactic Factors

Abstract 72: Induction of immune tolerance to recombinant immunotoxin LMB-100 using synthetic vaccine particles encapsulating rapamycin

Immune tolerance to recombinant immunotoxin LMB-100 using synthetic vaccine particles encapsulating rapamycin

Identification of N-terminal Residues on P-selectin Glycoprotein Ligand-1 Required for Binding to P-selectin

Contaminated Heparin Associated with Adverse Clinical Events and Activation of the Contact System

Adjuvant-carrying synthetic vaccine particles augment the immune response to encapsulated antigen and exhibit strong local immune activation without inducing systemic cytokine release

Rapamycin nanoparticles increase the therapeutic window of engineered interleukin-2 and drive expansion of antigen-specific regulatory T cells for protection against autoimmune disease

Generation of a universal CD4 memory T cell recall peptide effective in humans, mice and non-human primates

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