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Identification of a Selective, Non-Prostanoid EP2 Receptor Agonist for the Treatment of Glaucoma: Omidenepag and its Prodrug Omidenepag Isopropyl

Journal of medicinal chemistry, 2018-08, Vol.61 (15), p.6869-6891

2018

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Pharmacologic Characterization of Omidenepag Isopropyl, a Novel Selective EP2 Receptor Agonist, as an Ocular Hypotensive Agent

Investigative ophthalmology & visual science, 2018-01, Vol.59 (1), p.145-153

2018

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Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal Ganglion Cells via p38 MAPK Activity

Investigative ophthalmology & visual science, 2016-11, Vol.57 (14), p.6461-6473

2016

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Advantages of Efficacy and Safety of Fixed-Dose Tafluprost/Timolol Combination Over Fixed-Dose Latanoprost/Timolol Combination

PloS one, 2016-07, Vol.11 (7), p.e0158797

2016

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Ocular hypotensive efficacy of Src-family tyrosine kinase inhibitors via different cellular actions from Rock inhibitors

Experimental eye research, 2014-02, Vol.119, p.97-105

2014

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Effects of the New Ethacrynic Acid Oxime Derivative SA12590 on Intraocular Pressure in Cats and Monkeys

Biological and Pharmaceutical Bulletin, 2007/08/01, Vol.30(8), pp.1445-1449

2007

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A Novel Non‐Prostaglandin EP2‐Receptor Agonist for Glaucoma Treatment: Omidenepag Isopropyl (DE‐117)

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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Effects of the New Ethacrynic Acid Derivative SA9000 on Intraocular Pressure in Cats and Monkeys

Biological and Pharmaceutical Bulletin, 2004, Vol.27(7), pp.1019-1024

2004

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Reduced Plasma BDNF Levels in Normal Tension Glaucoma Compared to Open Angle Glaucoma

Journal of glaucoma, 2023-09, Vol.32 (9), p.734-737

2023

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Additive Intraocular Pressure-Lowering Effects of a Novel Selective EP2 Receptor Agonist, Omidenepag Isopropyl, Combined with Existing Antiglaucoma Agents in Conscious Ocular Normotensive Monkeys

Journal of ocular pharmacology and therapeutics, 2021-05, Vol.37 (4), p.223-229

2021

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Modulation of mPer1 gene expression by anxiolytic drugs in mouse cerebellum

British journal of pharmacology, 1999-12, Vol.128 (7), p.1616-1622

1999

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Molecular biomarkers in glaucoma

Investigative ophthalmology & visual science, 2013-01, Vol.54 (1), p.121-131

2013

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A novel synthesis of benzo- and indolo[a]quinolizidines by intramolecular diels-alder reaction of l-azadienes

Tetrahedron letters, 1984, Vol.25 (40), p.4541-4544

1984

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Stereocontrolled construction of octahydroquinolizines, octahydroindolizines, hexahydrobenzo[a]quinolizines, and an octahydroindolo[2,3-a]quinolizine by an intramolecular double Michael reaction: synthesis of (±)epilupinine

J. Chem. Soc., Perkin Trans. 1, 1987, p.1719-1726

1987

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Consturuction of Indolizidine and Quinolizidine Ring Systems by an Intramolecular 1-Aza-1,3-diene Diels-Alder Reaction. Synthesis of (±)-Epilupinine

Heterocycles, 1985, Vol.23 (5), p.1097

1985

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Novel Synthesis of Heterocyclic Compounds Having Angular Nitrogen Atom by Intramolecular Diels-Alder Reaction of 1-1-Azadienes

Heterocycles, 1985, Vol.23 (1), p.221

1985

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The Comparative Neurotoxicity of Intrathecal Lidocaine and Bupivacaine in Rats

Anesthesia and analgesia, 2005-08, Vol.101 (2), p.541-547

2005

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Population‐neuroscience study of the Tokyo TEEN Cohort (pn‐TTC): Cohort longitudinal study to explore the neurobiological substrates of adolescent psychological and behavioral development

Psychiatry and clinical neurosciences, 2019-05, Vol.73 (5), p.231-242

2019

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Comparative somatic and visceral antinociception and neurotoxicity of intrathecal bupivacaine, levobupivacaine, and dextrobupivacaine in rats

Anesthesiology (Philadelphia), 2006-06, Vol.104 (6), p.1249-1256

2006

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Growth patterns of body weight and tail feather length for Oriental Dollarbird nestlings in Japan

Bird Research, 2014, Vol.10, pp.S1-S4

2014

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ブッポウソウ雛の成長過程における体重と尾羽の変化

Bird Research, 2014, Vol.10, pp.S1-S4

2014

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A Statistical and Histopathological Study of Syrigoma at the Dermatological Clinic of University of Occupational and Environmental Health for the Period from 1979 to 1993

Nishi Nihon hifuka, 1995, Vol.57 (4), p.796-799

1995

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Identification of a Selective, Non-Prostanoid EP2 Receptor Agonist for the Treatment of Glaucoma: Omidenepag and its Prodrug Omidenepag Isopropyl

Pharmacologic Characterization of Omidenepag Isopropyl, a Novel Selective EP2 Receptor Agonist, as an Ocular Hypotensive Agent

Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal Ganglion Cells via p38 MAPK Activity

Advantages of Efficacy and Safety of Fixed-Dose Tafluprost/Timolol Combination Over Fixed-Dose Latanoprost/Timolol Combination

Ocular hypotensive efficacy of Src-family tyrosine kinase inhibitors via different cellular actions from Rock inhibitors

Effects of the New Ethacrynic Acid Oxime Derivative SA12590 on Intraocular Pressure in Cats and Monkeys

A Novel Non‐Prostaglandin EP2‐Receptor Agonist for Glaucoma Treatment: Omidenepag Isopropyl (DE‐117)

Effects of the New Ethacrynic Acid Derivative SA9000 on Intraocular Pressure in Cats and Monkeys

Reduced Plasma BDNF Levels in Normal Tension Glaucoma Compared to Open Angle Glaucoma

Additive Intraocular Pressure-Lowering Effects of a Novel Selective EP2 Receptor Agonist, Omidenepag Isopropyl, Combined with Existing Antiglaucoma Agents in Conscious Ocular Normotensive Monkeys

Modulation of mPer1 gene expression by anxiolytic drugs in mouse cerebellum

Molecular biomarkers in glaucoma

A novel synthesis of benzo- and indolo[a]quinolizidines by intramolecular diels-alder reaction of l-azadienes

Stereocontrolled construction of octahydroquinolizines, octahydroindolizines, hexahydrobenzo[a]quinolizines, and an octahydroindolo[2,3-a]quinolizine by an intramolecular double Michael reaction: synthesis of (±)epilupinine

Consturuction of Indolizidine and Quinolizidine Ring Systems by an Intramolecular 1-Aza-1,3-diene Diels-Alder Reaction. Synthesis of (±)-Epilupinine

Novel Synthesis of Heterocyclic Compounds Having Angular Nitrogen Atom by Intramolecular Diels-Alder Reaction of 1-1-Azadienes

The Comparative Neurotoxicity of Intrathecal Lidocaine and Bupivacaine in Rats

Population‐neuroscience study of the Tokyo TEEN Cohort (pn‐TTC): Cohort longitudinal study to explore the neurobiological substrates of adolescent psychological and behavioral development

Comparative somatic and visceral antinociception and neurotoxicity of intrathecal bupivacaine, levobupivacaine, and dextrobupivacaine in rats

Growth patterns of body weight and tail feather length for Oriental Dollarbird nestlings in Japan

ブッポウソウ雛の成長過程における体重と尾羽の変化

A Statistical and Histopathological Study of Syrigoma at the Dermatological Clinic of University of Occupational and Environmental Health for the Period from 1979 to 1993

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