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Discovery of 3‑Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

Journal of medicinal chemistry, 2020-07, Vol.63 (13), p.6876-6897

2020

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Computational toxicology in drug development

Drug discovery today, 2008-04, Vol.13 (7), p.303-310

2008

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Cardiac Safety of Kinase Inhibitors – Improving Understanding and Prediction of Liabilities in Drug Discovery Using Human Stem Cell-Derived Models

Frontiers in cardiovascular medicine, 2021-06, Vol.8, p.639824-639824

2021

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Report from the in vitro micronucleus assay working group

Mutation research, 2003-10, Vol.540 (2), p.153-163

2003

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Identification of a kinase profile that predicts chromosome damage induced by small molecule kinase inhibitors

PLoS computational biology, 2009-07, Vol.5 (7), p.e1000446

2009

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Mouse Lymphoma Thymidine Kinase Gene Mutation Assay: International Workshop on Genotoxicity Tests Workgroup Report—Plymouth, UK 2002

Mutation research, 2003-10, Vol.540 (2), p.127-140

2003

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Comparison of different cytotoxicity measures for the in vitro micronucleus test (MNVit) in L5178Y tk +/− cells: Summary of 4 compounds (Mitomycin C, Cyclophosphamide, Colchicine and Diethylstilboestrol) with clastogenic and aneugenic mode of action

Mutation research, 2010-10, Vol.702 (2), p.193-198

2010

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Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy

Journal of medicinal chemistry, 2016-07, Vol.59 (13), p.6086-6100

2016

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Comparison of different cytotoxicity measures for the in vitro micronucleus test (MNVit) in L5178Y tk^sup +/-^ cells: Summary of 4 compounds (Mitomycin C, Cyclophosphamide, Colchicine and Diethylstilboestrol) with clastogenic and aneugenic mode of action

Mutation research. Genetic toxicology and environmental mutagenesis, 2010-10, Vol.702 (2), p.193

2010

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Comparison of different cytotoxicity measures for the in vitro micronucleus test (MNVit) in L5178Y tk+/- cells: Summary of 4 compounds (Mitomycin C, Cyclophosphamide, Colchicine and Diethylstilboestrol) with clastogenic and aneugenic mode of action: Cytotoxicity Measures in the In Vitro Micronucleus Test

Mutation research. Genetic toxicology and environmental mutagenesis, 2010, Vol.702 (2), p.193-198

2010

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Using Ovality to Predict Nonmutagenic, Orally Efficacious Pyridazine Amides as Cell Specific Spleen Tyrosine Kinase Inhibitors

Journal of medicinal chemistry, 2014-03, Vol.57 (6), p.2683-2691

2014

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Corrigendum to “Report from the in vitro micronucleus assay working group” [Mutat. Res. 540 (2003) 153–163]

Mutation research. Genetic toxicology and environmental mutagenesis, 2004-11, Vol.564 (1), p.97-100

2004

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Evaluation of the GreenScreen GADD45α-GFP indicator assay with non-proprietary and proprietary compounds

Mutation research. Genetic toxicology and environmental mutagenesis, 2009-01, Vol.672 (1), p.10-16

2009

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Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase

Bioorganic & medicinal chemistry letters, 2011-06, Vol.21 (11), p.3237-3242

2011

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The mechanism of the solute-induced chain interdigitation in phosphatidylcholine vesicles and characterization of the isothermal phase transitions by means of dynamic light scattering

Biochimica et biophysica acta, 1992-11, Vol.1111 (2), p.263-269

1992

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Identification of a Kinase Profile that Predicts Chromosome Damage Induced by Small Molecule Kinase Inhibitors: e1000446

PLoS computational biology, 2009-07, Vol.5 (7)

2009

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Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien

Chemie ingenieur technik, 2007-07, Vol.79 (7), p.1052-1058

2007

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Response to “Genotoxic carcinogen or not genotoxic carcinogen? That is the question. Additional analysis of data from Olaharski et al.”

Mutation research. Genetic toxicology and environmental mutagenesis, 2009-01, Vol.672 (1), p.20-20

2009

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Evaluation of the GreenScreen GADD45a-GFP indicator assay with non-proprietary and proprietary compounds

Mutation research. Genetic toxicology and environmental mutagenesis, 2009-01, Vol.672 (1), p.10-16

2009

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Suppression of mutagenic activity of a series of 5HT2C receptor agonists by the incorporation of a gem-dimethyl group: SAR using the Ames test and a DNA unwinding assay

Mutagenesis, 1998-07, Vol.13 (4), p.397-403

1998

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Direct measurement of ion distributions between lipid membranes with X-ray diffraction

Biochimica et biophysica acta, 1996-03, Vol.1279 (2), p.181-189

Kirchner, Stephan

1996

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In vitro micronucleus assay with Chinese hamster V79 cells — results of a collaborative study with in situ exposure to 26 chemical substances

Mutation research, 2000-07, Vol.468 (2), p.137-163

2000

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New aspects of photogenotoxicity testing: Prevalidation of the photo-micronucleus test and the photo-comet assay

Toxicology (Amsterdam), 2006-09, Vol.226 (1), p.24-25

2006

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Kinases as Antitargets in Genotoxicity

Polypharmacology in Drug Discovery, 2012, p.63-81

2012

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Discovery of 3‑Pyridyl Isoindolin-1-one Derivatives as Potent, Selective, and Orally Active Aldosterone Synthase (CYP11B2) Inhibitors

Computational toxicology in drug development

Cardiac Safety of Kinase Inhibitors – Improving Understanding and Prediction of Liabilities in Drug Discovery Using Human Stem Cell-Derived Models

Report from the in vitro micronucleus assay working group

Identification of a kinase profile that predicts chromosome damage induced by small molecule kinase inhibitors

Mouse Lymphoma Thymidine Kinase Gene Mutation Assay: International Workshop on Genotoxicity Tests Workgroup Report—Plymouth, UK 2002

Comparison of different cytotoxicity measures for the in vitro micronucleus test (MNVit) in L5178Y tk +/− cells: Summary of 4 compounds (Mitomycin C, Cyclophosphamide, Colchicine and Diethylstilboestrol) with clastogenic and aneugenic mode of action

Specific Correction of Alternative Survival Motor Neuron 2 Splicing by Small Molecules: Discovery of a Potential Novel Medicine To Treat Spinal Muscular Atrophy

Comparison of different cytotoxicity measures for the in vitro micronucleus test (MNVit) in L5178Y tk^sup +/-^ cells: Summary of 4 compounds (Mitomycin C, Cyclophosphamide, Colchicine and Diethylstilboestrol) with clastogenic and aneugenic mode of action

How to reduce false positive results when undertaking in vitro genotoxicity testing and thus avoid unnecessary follow-up animal tests: Report of an ECVAM Workshop

Using Ovality to Predict Nonmutagenic, Orally Efficacious Pyridazine Amides as Cell Specific Spleen Tyrosine Kinase Inhibitors

Corrigendum to “Report from the in vitro micronucleus assay working group” [Mutat. Res. 540 (2003) 153–163]

Evaluation of the GreenScreen GADD45α-GFP indicator assay with non-proprietary and proprietary compounds

Orally active aminopyridines as inhibitors of tetrameric fructose-1,6-bisphosphatase

The mechanism of the solute-induced chain interdigitation in phosphatidylcholine vesicles and characterization of the isothermal phase transitions by means of dynamic light scattering

Identification of a Kinase Profile that Predicts Chromosome Damage Induced by Small Molecule Kinase Inhibitors: e1000446

Dynamische Membranbegasung im Bioreaktor zur Intensivierung der Sauerstoffversorgung empfindlicher Zelllinien

Response to “Genotoxic carcinogen or not genotoxic carcinogen? That is the question. Additional analysis of data from Olaharski et al.”

Evaluation of the GreenScreen GADD45a-GFP indicator assay with non-proprietary and proprietary compounds

Suppression of mutagenic activity of a series of 5HT2C receptor agonists by the incorporation of a gem-dimethyl group: SAR using the Ames test and a DNA unwinding assay

Direct measurement of ion distributions between lipid membranes with X-ray diffraction

In vitro micronucleus assay with Chinese hamster V79 cells — results of a collaborative study with in situ exposure to 26 chemical substances

New aspects of photogenotoxicity testing: Prevalidation of the photo-micronucleus test and the photo-comet assay

Kinases as Antitargets in Genotoxicity

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