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A landmark in drug discovery based on complex natural product synthesis

Scientific reports, 2019-06, Vol.9 (1), p.8656-9, Article 8656

2019

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Enhanced secretion of glucagon-like peptide 1 by biguanide compounds

Biochemical and biophysical research communications, 2002-11, Vol.298 (5), p.779-784

2002

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Metformin causes reduction of food intake and body weight gain and improvement of glucose intolerance in combination with dipeptidyl peptidase IV inhibitor in Zucker fa/fa rats

The Journal of pharmacology and experimental therapeutics, 2004-08, Vol.310 (2), p.614

2004

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Synthesis of the BCD-ring of ciguatoxin 1B using an acetylene cobalt complex and vinylsilane strategy

Tetrahedron, 2002-03, Vol.58 (10), p.1875-1888

2002

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Synthesis of the BCDE rings of ciguatoxin 1B via an acetylene biscobalthexacarbonyl–vinylsilane strategy

Tetrahedron letters, 2001-04, Vol.42 (15), p.2821-2824

2001

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7-But-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one is a novel competitive and selective inhibitor of dipeptidyl peptidase IV with an antihyperglycemic activity

The Journal of pharmacology and experimental therapeutics, 2006-12, Vol.319 (3), p.1253

2006

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Mechanistic studies on the hydrosilylation of an acetylene cobalt complex; trapping an active catalyst Co2(CO)6 causing olefin-isomerization and O-silylation

Tetrahedron, 2002-08, Vol.58 (32), p.6485-6492

2002

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Ten-Gram-Scale Total Synthesis of the Anticancer Drug Candidate E7130 to Supply Clinical Trials

Organic letters, 2024-04, Vol.26 (14), p.2837-2842

2024

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The combination of metformin and a dipeptidyl peptidase IV inhibitor prevents 5-fluorouracil-induced reduction of small intestine weight

European journal of pharmacology, 2004-03, Vol.488 (1), p.213-218

2004

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What Does It Take to Develop Structurally Complex Molecules by Total Synthesis? Rapid Process Development and GMP Manufacturing of E7130 Drug Substance for First-in-Human Clinical Study

Organic process research & development, 2024-06, Vol.28 (6), p.2077-2089

2024

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Sodium Hypophosphite Decomplexation of Acetylenebiscobalthexacarbonyls to cis-Olefins

Synlett, 2002, Vol.2002 (4), p.588-592

2002

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Abstract 4179: E7130 derived from total synthesis of halichondrin as a novel tumor-microenvironment ameliorator

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.4179-4179

2020

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Abstract 4183: Mechanism of action analysis of anti-CAF activity of E7130, a novel tumor-microenvironment ameliorator

Cancer research (Chicago, Ill.), 2020-08, Vol.80 (16_Supplement), p.4183-4183

2020

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E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo [4,5-d]pyridazin-4-one tosylate, is a novel, selective and competitive dipeptidyl peptidase-IV inhibitor

European journal of pharmacology, 2006-10, Vol.548 (1-3), p.181-187

2006

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Selective tissue factor/factor VIIa Inhibitor, ER-410660, and its prodrug, E5539, have anti-venous and anti-arterial thrombotic effects with a low risk of bleeding

Thrombosis research, 2013-08, Vol.132 (2), p.271-279

2013

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O3H-4-4 Finding of selective tissue factor/factor VIIa complex inhibitor as a novel anticoagulant with lower bleeding risk

Journal of Pharmacological Sciences, 2014-02, Vol.124 (suppl), p.136-136

2014

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Abstract 5564: Total synthesis of 6-deoxypladienolide D and assessment of splicing inhibitory activity in a mutant SF3B1 cancer cell line

Cancer research (Chicago, Ill.), 2015-08, Vol.75 (15_Supplement), p.5564-5564

2015

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Acetylene cobalt complex and vinylsilane strategy in the synthesis of ciguatoxin (D)EF analog

Tetrahedron letters, 2000-07, Vol.41 (31), p.5951-5955

2000

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Different C-Glycosidation Products of Glucal with Alkynyl or Propargyl Silanes under Acidic Conditions

Organic letters, 2003-12, Vol.5 (25), p.4883-4885

2003

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E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate, is a novel, selective and competitive dipeptidyl peptidase-IV inhibitor

European journal of pharmacology, 2006-10, Vol.548 (1-3), p.181

2006

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New Synthesis with Acetylene Biscobalthexacarbonyl Complex (2)

Journal of Synthetic Organic Chemistry, Japan, 2000/02/01, Vol.58(2), pp.99-107

2000

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New Synthesis with Acetylene Biscobalthexacarbonyl Complex (1)

Journal of Synthetic Organic Chemistry, Japan, 2000/01/01, Vol.58(1), pp.23-30

2000

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E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4 H-imidazo[4,5- d]pyridazin-4-one tosylate, is a novel, selective and competitive dipeptidyl peptidase-IV inhibitor

European journal of pharmacology, 2006, Vol.548 (1), p.181-187

2006

Volltextzugriff (PDF)

Mechanistic studies on the hydrosilylation of an acetylene cobalt complex; trapping an active catalyst Co 2(CO) 6 causing olefin-isomerization and O-silylation

Tetrahedron, 2002, Vol.58 (32), p.6485-6492

2002

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A landmark in drug discovery based on complex natural product synthesis

Enhanced secretion of glucagon-like peptide 1 by biguanide compounds

Metformin causes reduction of food intake and body weight gain and improvement of glucose intolerance in combination with dipeptidyl peptidase IV inhibitor in Zucker fa/fa rats

Synthesis of the BCD-ring of ciguatoxin 1B using an acetylene cobalt complex and vinylsilane strategy

Synthesis of the BCDE rings of ciguatoxin 1B via an acetylene biscobalthexacarbonyl–vinylsilane strategy

7-But-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin-8-one is a novel competitive and selective inhibitor of dipeptidyl peptidase IV with an antihyperglycemic activity

Mechanistic studies on the hydrosilylation of an acetylene cobalt complex; trapping an active catalyst Co2(CO)6 causing olefin-isomerization and O-silylation

Ten-Gram-Scale Total Synthesis of the Anticancer Drug Candidate E7130 to Supply Clinical Trials

The combination of metformin and a dipeptidyl peptidase IV inhibitor prevents 5-fluorouracil-induced reduction of small intestine weight

What Does It Take to Develop Structurally Complex Molecules by Total Synthesis? Rapid Process Development and GMP Manufacturing of E7130 Drug Substance for First-in-Human Clinical Study

Sodium Hypophosphite Decomplexation of Acetylenebiscobalthexacarbonyls to cis-Olefins

Abstract 4179: E7130 derived from total synthesis of halichondrin as a novel tumor-microenvironment ameliorator

Abstract 4183: Mechanism of action analysis of anti-CAF activity of E7130, a novel tumor-microenvironment ameliorator

E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo [4,5-d]pyridazin-4-one tosylate, is a novel, selective and competitive dipeptidyl peptidase-IV inhibitor

Selective tissue factor/factor VIIa Inhibitor, ER-410660, and its prodrug, E5539, have anti-venous and anti-arterial thrombotic effects with a low risk of bleeding

Total Synthesis of 6‑Deoxypladienolide D and Assessment of Splicing Inhibitory Activity in a Mutant SF3B1 Cancer Cell Line

O3H-4-4 Finding of selective tissue factor/factor VIIa complex inhibitor as a novel anticoagulant with lower bleeding risk

Abstract 5564: Total synthesis of 6-deoxypladienolide D and assessment of splicing inhibitory activity in a mutant SF3B1 cancer cell line

Acetylene cobalt complex and vinylsilane strategy in the synthesis of ciguatoxin (D)EF analog

Different C-Glycosidation Products of Glucal with Alkynyl or Propargyl Silanes under Acidic Conditions

E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyridazin-4-one tosylate, is a novel, selective and competitive dipeptidyl peptidase-IV inhibitor

New Synthesis with Acetylene Biscobalthexacarbonyl Complex (2)

New Synthesis with Acetylene Biscobalthexacarbonyl Complex (1)

E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4 H-imidazo[4,5- d]pyridazin-4-one tosylate, is a novel, selective and competitive dipeptidyl peptidase-IV inhibitor

Mechanistic studies on the hydrosilylation of an acetylene cobalt complex; trapping an active catalyst Co 2(CO) 6 causing olefin-isomerization and O-silylation

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