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Thromboxane A2 signalling in humans: a 'Tail' of two receptors

Biochemical Society transactions, 2001-11, Vol.29 (Pt 6), p.641-654

Kinsella, B T

2001

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Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase

The Journal of biological chemistry, 1992-11, Vol.267 (33), p.23575-23582

1992

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Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA

The Journal of biological chemistry, 1991-05, Vol.266 (15), p.9786-9794

1991

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The thromboxane receptor antagonist NTP42 improves haemodynamics, inhibits remodelling, and restores function within the cardiopulmonary system in preclinical pulmonary arterial hypertension models

European heart journal, 2021-10, Vol.42 (Supplement_1)

2021

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Posttranslational Modification of Ha-ras p21 by Farnesyl Versus Geranylgeranyl Isoprenoids is Determined by the COOH-Terminal Amino Acid

Proceedings of the National Academy of Sciences - PNAS, 1991-10, Vol.88 (20), p.8934-8938

1991

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rab GTP-binding proteins implicated in vesicular transport are isoprenylated in vitro at cysteines within a novel carboxyl-terminal motif

The Journal of biological chemistry, 1991-05, Vol.266 (13), p.8540-8544

1991

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The effects of the statins lovastatin and cerivastatin on signalling by the prostanoid IP‐receptor

British journal of pharmacology, 2001-04, Vol.132 (8), p.1639-1649

2001

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Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling

The Journal of biological chemistry, 2001-09, Vol.276 (36), p.33596

2001

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Thromboxane A(2) receptor mediated activation of the mitogen activated protein kinase cascades in human uterine smooth muscle cells

Biochimica et biophysica acta, 2001-05, Vol.1539 (1-2), p.147

2001

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rab GTP-binding proteins with three different carboxyl-terminal cysteine motifs are modified in vivo by 20-carbon isoprenoids

The Journal of biological chemistry, 1992-02, Vol.267 (6), p.3940-3945

1992

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Investigation of the role of the carboxyl-terminal tails of the alpha and beta isoforms of the human thromboxane A(2) receptor (TP) in mediating receptor:effector coupling

Biochimica et biophysica acta, 2000-04, Vol.1496 (2-3), p.164

2000

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The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling

The Journal of biological chemistry, 1999-08, Vol.274 (34), p.23707-23718

1999

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Estrogen Increases Expression of the Human Prostacyclin Receptor within the Vasculature through an ERα-Dependent Mechanism

Journal of molecular biology, 2010-02, Vol.396 (3), p.473-486

2010

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Regulation of the human prostanoid TPα and TPβ receptor isoforms mediated through activation of the EP1 and IP receptors

British journal of pharmacology, 2000-10, Vol.131 (3), p.601-609

2000

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Phosphorylation and regulated expression of the human thromboxane A2 receptor

The Journal of biological chemistry, 1994-11, Vol.269 (47), p.29914-29919

1994

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Molecular cloning and characterization of a Candida tsukubaensis alpha-glucosidase gene in the yeast Saccharomyces cerevisiae

Current genetics, 1991-07, Vol.20 (1-2), p.45-52

1991

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Analysis of the expression and secretion of the Candida tsukubaensis α‐glucosidase gene in the yeast Saccharomyces cerevisiae

Yeast (Chichester, England), 1991-07, Vol.7 (5), p.445-454

1991

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Transcriptional Regulation of the Human Prostacyclin Receptor Gene Is Dependent on Sp1, PU.1 and Oct-1 in Megakaryocytes and Endothelial Cells

Journal of molecular biology, 2009-02, Vol.386 (3), p.579-597

2009

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Primary structure and processing of the Candida tsukubaensis α-glucosidase : homology with the rabbit intestinal sucrase-isomaltase complex and human lysosomal α-glucosidase

European journal of biochemistry, 1991-12, Vol.202 (2), p.657-664

1991

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Thromboxane A2 receptor mediated activation of the mitogen activated protein kinase cascades in human uterine smooth muscle cells

Biochimica et biophysica acta. Molecular cell research, 2001-05, Vol.1539 (1-2), p.147-162

2001

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The α, but Not the β, Isoform of the Human Thromboxane A2 Receptor Is a Target for Prostacyclin-mediated Desensitization

The Journal of biological chemistry, 2000-07, Vol.275 (27), p.20412-20423

2000

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Outcomes of Chemoradiotherapy With 5-Fluorouracil and Mitomycin C for Anal Cancer in Immunocompetent Versus Immunodeficient Patients

International journal of radiation oncology, biology, physics, 2009-09, Vol.75 (1), p.143-149

2009

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The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for nitric oxide-mediated desensitization. Independent modulation of Tp alpha signaling by nitric oxide and prostacyclin

The Journal of biological chemistry, 2003-12, Vol.278 (51), p.51190

2003

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Design, Synthesis, and SAR Study of a Series of N-Alkyl-N'-[2-(aryloxy)-5-nitrobenzenesulfonyl]ureas and -cyanoguanidine as Selective Antagonists of the TP alpha and TP beta Isoforms of the Human Thromboxane A sub(2) Receptor

Journal of medicinal chemistry, 2007-08, Vol.50 (16), p.3928-3936

2007

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Transcription from the rat 45S ribosomal DNA promoter does not require the factor UBF

Gene expression, 1993, Vol.3 (3), p.229-236

1993

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Thromboxane A2 signalling in humans: a 'Tail' of two receptors

Purification and characterization of Rac 2. A cytosolic GTP-binding protein that regulates human neutrophil NADPH oxidase

Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by rac1, rac2, and ralA

The thromboxane receptor antagonist NTP42 improves haemodynamics, inhibits remodelling, and restores function within the cardiopulmonary system in preclinical pulmonary arterial hypertension models

Posttranslational Modification of Ha-ras p21 by Farnesyl Versus Geranylgeranyl Isoprenoids is Determined by the COOH-Terminal Amino Acid

rab GTP-binding proteins implicated in vesicular transport are isoprenylated in vitro at cysteines within a novel carboxyl-terminal motif

The effects of the statins lovastatin and cerivastatin on signalling by the prostanoid IP‐receptor

Protein kinase A-mediated phosphorylation of serine 357 of the mouse prostacyclin receptor regulates its coupling to G(s)-, to G(i)-, and to G(q)-coupled effector signaling

Thromboxane A(2) receptor mediated activation of the mitogen activated protein kinase cascades in human uterine smooth muscle cells

rab GTP-binding proteins with three different carboxyl-terminal cysteine motifs are modified in vivo by 20-carbon isoprenoids

Investigation of the role of the carboxyl-terminal tails of the alpha and beta isoforms of the human thromboxane A(2) receptor (TP) in mediating receptor:effector coupling

The prostacyclin receptor is isoprenylated. Isoprenylation is required for efficient receptor-effector coupling

Estrogen Increases Expression of the Human Prostacyclin Receptor within the Vasculature through an ERα-Dependent Mechanism

Regulation of the human prostanoid TPα and TPβ receptor isoforms mediated through activation of the EP1 and IP receptors

Phosphorylation and regulated expression of the human thromboxane A2 receptor

Molecular cloning and characterization of a Candida tsukubaensis alpha-glucosidase gene in the yeast Saccharomyces cerevisiae

Analysis of the expression and secretion of the Candida tsukubaensis α‐glucosidase gene in the yeast Saccharomyces cerevisiae

Transcriptional Regulation of the Human Prostacyclin Receptor Gene Is Dependent on Sp1, PU.1 and Oct-1 in Megakaryocytes and Endothelial Cells

Primary structure and processing of the Candida tsukubaensis α-glucosidase : homology with the rabbit intestinal sucrase-isomaltase complex and human lysosomal α-glucosidase

Thromboxane A2 receptor mediated activation of the mitogen activated protein kinase cascades in human uterine smooth muscle cells

The α, but Not the β, Isoform of the Human Thromboxane A2 Receptor Is a Target for Prostacyclin-mediated Desensitization

Outcomes of Chemoradiotherapy With 5-Fluorouracil and Mitomycin C for Anal Cancer in Immunocompetent Versus Immunodeficient Patients

The alpha, but not the beta, isoform of the human thromboxane A2 receptor is a target for nitric oxide-mediated desensitization. Independent modulation of Tp alpha signaling by nitric oxide and prostacyclin

Design, Synthesis, and SAR Study of a Series of N-Alkyl-N'-[2-(aryloxy)-5-nitrobenzenesulfonyl]ureas and -cyanoguanidine as Selective Antagonists of the TP alpha and TP beta Isoforms of the Human Thromboxane A sub(2) Receptor

Transcription from the rat 45S ribosomal DNA promoter does not require the factor UBF

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