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CBP-Mediated Acetylation of Importin α Mediates Calcium-Dependent Nucleocytoplasmic Transport of Selective Proteins in Drosophila Neurons

Molecules and Cells, 2022, 45(11), , pp.855-867

2022

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The indole derivative NecroX-7 improves nonalcoholic steatohepatitis in ob/ob mice through suppression of mitochondrial ROS/RNS and inflammation

Liver international, 2015-04, Vol.35 (4), p.1341-1353

2015

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The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism

Nature communications, 2023-09, Vol.14 (1), p.5728-5728, Article 5728

2023

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In vitro broad-spectrum antiviral activity of MIT-001, a mitochondria-targeted reactive oxygen species scavenger, against severe acute respiratory syndrome coronavirus 2 and multiple zoonotic viruses

Virus research, 2024-04, Vol.342, p.199325-199325, Article 199325

2024

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Therapeutic Potential of a Novel Necrosis Inhibitor, 7-Amino-Indole, in Myocardial Ischemia–Reperfusion Injury

Hypertension (Dallas, Tex. 1979), 2018-06, Vol.71 (6), p.1143-1155

2018

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Mitigating Age-Related Ovarian Dysfunction with the Anti-Inflammatory Agent MIT-001

International journal of molecular sciences, 2023-10, Vol.24 (20), p.15158

2023

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Airway epithelial phosphoinositide 3-kinase-δ contributes to the modulation of fungi-induced innate immune response

Thorax, 2018-08, Vol.73 (8), p.758-768

2018

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MIT-001 Restores Human Placenta-Derived Mesenchymal Stem Cells by Enhancing Mitochondrial Quiescence and Cytoskeletal Organization

International journal of molecular sciences, 2021-05, Vol.22 (10), p.5062

2021

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Pharmacokinetics and Tolerability of LC28-0126, a Novel Necrosis Inhibitor, After Multiple Ascending Doses: A Phase I Randomized, Double-blind, Placebo-controlled Study in Healthy Male Subjects

Clinical therapeutics, 2020-10, Vol.42 (10), p.1946-1954.e2

2020

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Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis

Virulence, 2020-12, Vol.11 (1), p.1225-1239

2020

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The Effect of Necrosis Inhibitor on Dextran Sulfate Sodium Induced Chronic Colitis Model in Mice

Pharmaceutics, 2023-01, Vol.15 (1), p.222

2023

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An indole derivative protects against acetaminophen-induced liver injury by directly binding to N-acetyl-p-benzoquinone imine in mice

Antioxidants & redox signaling, 2013-05, Vol.18 (14), p.1713-1722

2013

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NecroX as a novel class of mitochondrial reactive oxygen species and ONOO− scavenger

Archives of Pharmacal Research, 2010, 33(11), , pp.1813-1823

2010

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Germ Line Deletion of the CD1 Locus Exacerbates Diabetes in the NOD Mouse

Proceedings of the National Academy of Sciences - PNAS, 2001-06, Vol.98 (12), p.6777-6782

2001

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NecroX-7 prevents oxidative stress-induced cardiomyopathy by inhibition of NADPH oxidase activity in rats

Toxicology and applied pharmacology, 2012-08, Vol.263 (1), p.1-6

2012

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Evaluation of the Safety and Efficacy for Oral Mucositis Prevention of MIT-001 in Auto HSCT

Blood, 2023-11, Vol.142 (Supplement 1), p.2227-2227

2023

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NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNFα/Dcn/TGFβ1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts

The Korean journal of physiology & pharmacology, 2016-01, Vol.20 (3), p.305-314

2016

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NecroX Improves Polyhexamethylene Guanidine-induced Lung Injury by Regulating Mitochondrial Oxidative Stress and Endoplasmic Reticulum Stress

American journal of respiratory cell and molecular biology, 2023-07, Vol.69 (1), p.57-72

2023

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Drug Signature-based Finding of Additional Clinical Use of LC28-0126 for Neutrophilic Bronchial Asthma

Scientific reports, 2015-12, Vol.5 (1), p.17784-17784, Article 17784

2015

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Engagement of CD99 Induces Apoptosis Through a Calcineurin-Independent Pathway in Ewing's Sarcoma Cells

The American journal of pathology, 1998-12, Vol.153 (6), p.1937-1945

1998

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The Free Radical Scavenger NecroX-7 Attenuates Acute Graft-versus-Host Disease via Reciprocal Regulation of Th1/Regulatory T Cells and Inhibition of HMGB1 Release

The Journal of immunology (1950), 2015-06, Vol.194 (11), p.5223-5232

2015

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CBP-Mediated Acetylation of Importin α Mediates Calcium-Dependent Nucleocytoplasmic Transport of Selective Proteins in Drosophila Neurons

Molecules and cells, 2022, Vol.45 (11), p.855-867

2022

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Neuroprotective effect of NecroX-5 against retinal degeneration in rodents

Neuroreport, 2016-10, Vol.27 (15), p.1128-1133

2016

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Engagement of CD99 Induces Up-Regulation of TCR and MHC Class I and II Molecules on the Surface of Human Thymocytes

The Journal of immunology (1950), 1998-07, Vol.161 (2), p.749-754

1998

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Control of the Autoimmune Response by Type 2 Nitric Oxide Synthase

The Journal of immunology (1950), 2001-09, Vol.167 (5), p.3000-3006

2001

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CBP-Mediated Acetylation of Importin α Mediates Calcium-Dependent Nucleocytoplasmic Transport of Selective Proteins in Drosophila Neurons

The indole derivative NecroX-7 improves nonalcoholic steatohepatitis in ob/ob mice through suppression of mitochondrial ROS/RNS and inflammation

The lipoprotein-associated phospholipase A2 inhibitor Darapladib sensitises cancer cells to ferroptosis by remodelling lipid metabolism

In vitro broad-spectrum antiviral activity of MIT-001, a mitochondria-targeted reactive oxygen species scavenger, against severe acute respiratory syndrome coronavirus 2 and multiple zoonotic viruses

Therapeutic Potential of a Novel Necrosis Inhibitor, 7-Amino-Indole, in Myocardial Ischemia–Reperfusion Injury

Mitigating Age-Related Ovarian Dysfunction with the Anti-Inflammatory Agent MIT-001

Airway epithelial phosphoinositide 3-kinase-δ contributes to the modulation of fungi-induced innate immune response

MIT-001 Restores Human Placenta-Derived Mesenchymal Stem Cells by Enhancing Mitochondrial Quiescence and Cytoskeletal Organization

Pharmacokinetics and Tolerability of LC28-0126, a Novel Necrosis Inhibitor, After Multiple Ascending Doses: A Phase I Randomized, Double-blind, Placebo-controlled Study in Healthy Male Subjects

Sirtuin 3 is essential for host defense against Mycobacterium abscessus infection through regulation of mitochondrial homeostasis

The Effect of Necrosis Inhibitor on Dextran Sulfate Sodium Induced Chronic Colitis Model in Mice

An indole derivative protects against acetaminophen-induced liver injury by directly binding to N-acetyl-p-benzoquinone imine in mice

NecroX as a novel class of mitochondrial reactive oxygen species and ONOO− scavenger

Germ Line Deletion of the CD1 Locus Exacerbates Diabetes in the NOD Mouse

NecroX-7 prevents oxidative stress-induced cardiomyopathy by inhibition of NADPH oxidase activity in rats

Evaluation of the Safety and Efficacy for Oral Mucositis Prevention of MIT-001 in Auto HSCT

NecroX-5 exerts anti-inflammatory and anti-fibrotic effects via modulation of the TNFα/Dcn/TGFβ1/Smad2 pathway in hypoxia/reoxygenation-treated rat hearts

NecroX Improves Polyhexamethylene Guanidine-induced Lung Injury by Regulating Mitochondrial Oxidative Stress and Endoplasmic Reticulum Stress

Drug Signature-based Finding of Additional Clinical Use of LC28-0126 for Neutrophilic Bronchial Asthma

Engagement of CD99 Induces Apoptosis Through a Calcineurin-Independent Pathway in Ewing's Sarcoma Cells

The Free Radical Scavenger NecroX-7 Attenuates Acute Graft-versus-Host Disease via Reciprocal Regulation of Th1/Regulatory T Cells and Inhibition of HMGB1 Release

CBP-Mediated Acetylation of Importin α Mediates Calcium-Dependent Nucleocytoplasmic Transport of Selective Proteins in Drosophila Neurons

Neuroprotective effect of NecroX-5 against retinal degeneration in rodents

Engagement of CD99 Induces Up-Regulation of TCR and MHC Class I and II Molecules on the Surface of Human Thymocytes

Control of the Autoimmune Response by Type 2 Nitric Oxide Synthase

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