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GDF15 as a central mediator for integrated stress response and a promising therapeutic molecule for metabolic disorders and NASH

Biochimica et biophysica acta. General subjects, 2021-03, Vol.1865 (3), p.129834-129834, Article 129834

2021

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Targeting of Secretory Proteins as a Therapeutic Strategy for Treatment of Nonalcoholic Steatohepatitis (NASH)

International journal of molecular sciences, 2020-03, Vol.21 (7), p.2296

2020

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Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

Nature medicine, 2013-01, Vol.19 (1), p.83-92

2013

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Acute exercise induces FGF21 expression in mice and in healthy humans

PloS one, 2013-05, Vol.8 (5), p.e63517-e63517

2013

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Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition

Autophagy, 2017-10, Vol.13 (10), p.1767-1781

2017

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Pathogenesis of Nonalcoholic Steatohepatitis and Hormone-Based Therapeutic Approaches

Frontiers in endocrinology (Lausanne), 2018-08, Vol.9, p.485-485

2018

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A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes

Nature communications, 2018-04, Vol.9 (1), p.1438-14, Article 1438

2018

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FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs

Journal of endocrinology, 2015-07, Vol.226 (1), p.R1-R16

2015

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FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases

Diabetes and Metabolism Journal, 2014, 38(4), 144, pp.245-251

2014

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An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer

Nature communications, 2021-01, Vol.12 (1), p.183-183, Article 183

2021

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Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice

Scientific reports, 2018-05, Vol.8 (1), p.6789-14, Article 6789

2018

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Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress

Diabetologia, 2015-04, Vol.58 (4), p.809-818

2015

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Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway

FEBS letters, 2010-02, Vol.584 (4), p.707-712

2010

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Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress

Autophagy, 2023-07, Vol.19 (7), p.2111-2142

2023

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Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation

Biochemical and biophysical research communications, 2013-10, Vol.440 (1), p.76-81

2013

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Hepatitis B virus X protein induces lipogenic transcription factor SREBP1 and fatty acid synthase through the activation of nuclear receptor LXRα

Biochemical journal, 2008-12, Vol.416 (2), p.219-230

2008

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TFEB-GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response

Nature metabolism, 2021-03, Vol.3 (3), p.410

2021

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Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3

PloS one, 2010-03, Vol.5 (3), p.e8649-e8649

2010

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Snail acetylation by autophagy‐derived acetyl‐coenzyme A promotes invasion and metastasis of KRAS‐LKB1 co‐mutated lung cancer cells

Cancer communications (London, England), 2022-08, Vol.42 (8), p.716-749

2022

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Cell non-autonomous effect of hepatic growth differentiation factor 15 on the thyroid gland

Frontiers in endocrinology (Lausanne), 2022-08, Vol.13, p.966644-966644

2022

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Autophagy--a key player in cellular and body metabolism

Nature reviews. Endocrinology, 2014-06, Vol.10 (6), p.322

2014

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Hepatitis C virus NS5A protein increases hepatic lipid accumulation via induction of activation and expression of PPARgamma

FEBS letters, 2009-09, Vol.583 (17), p.2720-2726

2009

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SHP (small heterodimer partner) suppresses the transcriptional activity and nuclear localization of Hedgehog signalling protein Gli1

Biochemical journal, 2010-05, Vol.427 (3), p.413-422

2010

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Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes

The Journal of clinical investigation, 2014-08, Vol.124 (8), p.3311-3324

2014

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Autophagy as a crosstalk mediator of metabolic organs in regulation of energy metabolism

Reviews in endocrine & metabolic disorders, 2014-03, Vol.15 (1), p.11-20

2014

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GDF15 as a central mediator for integrated stress response and a promising therapeutic molecule for metabolic disorders and NASH

Targeting of Secretory Proteins as a Therapeutic Strategy for Treatment of Nonalcoholic Steatohepatitis (NASH)

Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine

Acute exercise induces FGF21 expression in mice and in healthy humans

Ezetimibe ameliorates steatohepatitis via AMP activated protein kinase-TFEB-mediated activation of autophagy and NLRP3 inflammasome inhibition

Pathogenesis of Nonalcoholic Steatohepatitis and Hormone-Based Therapeutic Approaches

A novel autophagy enhancer as a therapeutic agent against metabolic syndrome and diabetes

FGF21 as a mediator of adaptive responses to stress and metabolic benefits of anti-diabetic drugs

FGF21 as a Stress Hormone: The Roles of FGF21 in Stress Adaptation and the Treatment of Metabolic Diseases

An autophagy enhancer ameliorates diabetes of human IAPP-transgenic mice through clearance of amyloidogenic oligomer

Growth differentiation factor 15 ameliorates nonalcoholic steatohepatitis and related metabolic disorders in mice

Fibroblast growth factor 21 participates in adaptation to endoplasmic reticulum stress and attenuates obesity-induced hepatic metabolic stress

Curcumin inhibits hepatitis C virus replication via suppressing the Akt-SREBP-1 pathway

Phosphorylation of EIF2S1 (eukaryotic translation initiation factor 2 subunit alpha) is indispensable for nuclear translocation of TFEB and TFE3 during ER stress

Metformin-induced inhibition of the mitochondrial respiratory chain increases FGF21 expression via ATF4 activation

Hepatitis B virus X protein induces lipogenic transcription factor SREBP1 and fatty acid synthase through the activation of nuclear receptor LXRα

TFEB-GDF15 axis protects against obesity and insulin resistance as a lysosomal stress response

Hepatitis B virus X protein impairs hepatic insulin signaling through degradation of IRS1 and induction of SOCS3

Snail acetylation by autophagy‐derived acetyl‐coenzyme A promotes invasion and metastasis of KRAS‐LKB1 co‐mutated lung cancer cells

Cell non-autonomous effect of hepatic growth differentiation factor 15 on the thyroid gland

Autophagy--a key player in cellular and body metabolism

Hepatitis C virus NS5A protein increases hepatic lipid accumulation via induction of activation and expression of PPARgamma

SHP (small heterodimer partner) suppresses the transcriptional activity and nuclear localization of Hedgehog signalling protein Gli1

Amyloidogenic peptide oligomer accumulation in autophagy-deficient β cells induces diabetes

Autophagy as a crosstalk mediator of metabolic organs in regulation of energy metabolism

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