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Synthesis and Antitumor Activity of a Series of [2-Substituted-4,5-bis(aminomethyl)-1,3-Dioxolane]platinum(II) Complexes

Journal of medicinal chemistry, 1994-05, Vol.37 (10), p.1471-1485

1994

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Synthesis and Anti-HIV-1 Activity of a Series of 1-Alkoxy-5-alkyl-6-(arylthio)uracils

Journal of medicinal chemistry, 1997-07, Vol.40 (15), p.2363-2373

1997

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Synthesis and Evaluation of 2-Amino-9-(3-hydroxymethyl-4-alkoxycarbonyloxybut-1-yl)purines as Potential Prodrugs of Penciclovir

Journal of medicinal chemistry, 1998-08, Vol.41 (18), p.3435-3441

1998

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A Phase I study of cis‐malonato[(4R,5R)‐4,5‐bis(aminomethyl)‐1,3‐dioxolane] platinum(II) in patients with advanced malignancies

Cancer, 2001-04, Vol.91 (8), p.1549-1556

2001

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Effect of SKI 306X, a new herbal anti-arthritic agent, in patients with osteoarthritis of the knee: a double-blind placebo controlled study

The American journal of Chinese medicine (1979), 2001, Vol.29 (3-4), p.485-491

2001

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Synthesis and evaluation of 2-amino-6-fluoro-9-(2-hydroxyethoxymethyl)purine esters as potential prodrugs of acyclovir

Bioorganic & medicinal chemistry, 1998-12, Vol.6 (12), p.2525-2530

1998

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Synthesis and evaluation of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines and 2-amino-9-(3-alkoxycarbonyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines as potential prodrugs of penciclovir

Bioorganic & medicinal chemistry, 1999-08, Vol.7 (8), p.1715-1725

1999

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Synthesis and evaluation of 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxymethylbut-1-yl)purine mono- and diesters as potential prodrugs of penciclovir

Bioorganic & medicinal chemistry, 1999-03, Vol.7 (3), p.565-570

1999

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Synthesis and Evaluation of 2-Amino-9-(1,3-dihydroxy-2-propoxymethyl)- 6-fluoropurine Mono- and Diesters as Potential Prodrugs of Ganciclovir

Journal of medicinal chemistry, 1999-01, Vol.42 (2), p.324-328

1999

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Synthesis and evaluation of amino acid esters of 6-deoxypenciclovir as potential prodrugs of penciclovir

Bioorganic & medicinal chemistry, 1999-02, Vol.7 (2), p.419-424

1999

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A convenient approach to the synthesis of 6-substituted 1,5-dialkyluracils and -2-thiouracils

Tetrahedron letters, 1995-08, Vol.36 (35), p.6257-6260

1995

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Antitumor activity of five new platinum complexes having a glycolate leaving ligand

Journal of Korean medical science, 1995-08, Vol.10 (4), p.269-274

1995

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Phase II trial of a novel platinum analog, SKI 2053R, in patients with previously untreated extensive-stage small-cell lung cancer

American journal of clinical oncology, 1999-10, Vol.22 (5), p.495-498

1999

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General pharmacology of the new antiviral agent SK 1899

Arzneimittel-Forschung, 2000-04, Vol.50 (4), p.395-403

2000

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Synthesis and in vitro cytotoxicity of cis-dichloro[(2 S,3 R,4 S)-2-aminomethyl-3,4-( O-isopropylidene)dihydroxy- or -3,4-dihydroxypyrrolidine]platinum(II)

Bioorganic & medicinal chemistry letters, 1996-03, Vol.6 (6), p.643-646

1996

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A Phase I study ofcis-malonato[(4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane] platinum(II) in patients with advanced malignancies

Cancer, 2001-04, Vol.91 (8), p.1549-1556

2001

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Pharmacokinetics and antitumor activity of a new platinum compound, cis-malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]platinum(II), as determined by ex vivo pharmacodynamics

Cancer chemotherapy and pharmacology, 1995, Vol.37 (1-2), p.1-6

1995

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Antiviral activity of 9-[[(ethoxyhydroxyphosphinyl)-methoxy]methoxy]guanine against cytomegalovirus and herpes simplex virus

Antiviral research, 1995-11, Vol.28 (3), p.243-251

1995

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Pharmacokinetics of platinum following the administration of cis-(glycolato-O,O')[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1, 3-dioxolane]platinum(II) in dogs

Anticancer research, 1997-09, Vol.17 (5A), p.3681

1997

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Antitumor activity of cis-malonato[(4R,5R)-4,5-bis(aminomethy1)-2-isopropyl-1,3-dioxolanelplatinum(II), a new platinum analogue, as an anticancer agent

Cancer chemotherapy and pharmacology, 1995-01, Vol.35 (5), p.441-445

1995

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Synthesis of carbon-14 labelled 2-amino-9-(3-hydroxymethyl-4-isopropoxycarbonyloxybut-1-yl)purine (SK1875), a potential prodrug of penciclovir

Journal of labelled compounds & radiopharmaceuticals, 1999-06, Vol.42 (6), p.597-604

1999

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Synthesis and evaluation of amino acid ester prodrugs of penciclovir

Bioorganic & medicinal chemistry letters, 1996-08, Vol.6 (15), p.1849-1854

1996

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Enantioselective synthesis of ( R)- and ( S)-2-alkyl-1,4-butanediols via enantiomerically pure 3-alkyl-5-(menthyloxy)butyrolactones

Tetrahedron letters, 1996-04, Vol.37 (14), p.2429-2432

1996

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Synthesis and anti-HIV-1 activity of a series of 1-(alkoxymethyl)-5-alkyl-6-(arylselenenyl)uracils and -2-thiouracils

Journal of heterocyclic chemistry, 1996-07, Vol.33 (4), p.1275-1283

1996

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Synthesis and in vitro cytotoxicity of cis-(glycolato- O, O′)-[2-substituted-(4 R,5 R)-4,5-bis(aminomethyl)-1,3-dioxolane]platinum (II)

Bioorganic & medicinal chemistry letters, 1996-04, Vol.6 (7), p.771-774

1996

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Synthesis and Antitumor Activity of a Series of [2-Substituted-4,5-bis(aminomethyl)-1,3-Dioxolane]platinum(II) Complexes

Synthesis and Anti-HIV-1 Activity of a Series of 1-Alkoxy-5-alkyl-6-(arylthio)uracils

Synthesis and Evaluation of 2-Amino-9-(3-hydroxymethyl-4-alkoxycarbonyloxybut-1-yl)purines as Potential Prodrugs of Penciclovir

A Phase I study of cis‐malonato[(4R,5R)‐4,5‐bis(aminomethyl)‐1,3‐dioxolane] platinum(II) in patients with advanced malignancies

Effect of SKI 306X, a new herbal anti-arthritic agent, in patients with osteoarthritis of the knee: a double-blind placebo controlled study

Synthesis and evaluation of 2-amino-6-fluoro-9-(2-hydroxyethoxymethyl)purine esters as potential prodrugs of acyclovir

Synthesis and evaluation of 2-amino-9-(3-acyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines and 2-amino-9-(3-alkoxycarbonyloxymethyl-4-alkoxycarbonyloxybut-1-yl)purines as potential prodrugs of penciclovir

Synthesis and evaluation of 2-amino-6-fluoro-9-(4-hydroxy-3-hydroxymethylbut-1-yl)purine mono- and diesters as potential prodrugs of penciclovir

Synthesis and Evaluation of 2-Amino-9-(1,3-dihydroxy-2-propoxymethyl)- 6-fluoropurine Mono- and Diesters as Potential Prodrugs of Ganciclovir

Synthesis and evaluation of amino acid esters of 6-deoxypenciclovir as potential prodrugs of penciclovir

A convenient approach to the synthesis of 6-substituted 1,5-dialkyluracils and -2-thiouracils

Antitumor activity of five new platinum complexes having a glycolate leaving ligand

Phase II trial of a novel platinum analog, SKI 2053R, in patients with previously untreated extensive-stage small-cell lung cancer

General pharmacology of the new antiviral agent SK 1899

Synthesis and in vitro cytotoxicity of cis-dichloro[(2 S,3 R,4 S)-2-aminomethyl-3,4-( O-isopropylidene)dihydroxy- or -3,4-dihydroxypyrrolidine]platinum(II)

A Phase I study ofcis-malonato[(4R,5R)-4,5-bis(aminomethyl)-1,3-dioxolane] platinum(II) in patients with advanced malignancies

Pharmacokinetics and antitumor activity of a new platinum compound, cis-malonato[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane]platinum(II), as determined by ex vivo pharmacodynamics

Antiviral activity of 9-[[(ethoxyhydroxyphosphinyl)-methoxy]methoxy]guanine against cytomegalovirus and herpes simplex virus

Pharmacokinetics of platinum following the administration of cis-(glycolato-O,O')[(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1, 3-dioxolane]platinum(II) in dogs

Antitumor activity of cis-malonato[(4R,5R)-4,5-bis(aminomethy1)-2-isopropyl-1,3-dioxolanelplatinum(II), a new platinum analogue, as an anticancer agent

Synthesis of carbon-14 labelled 2-amino-9-(3-hydroxymethyl-4-isopropoxycarbonyloxybut-1-yl)purine (SK1875), a potential prodrug of penciclovir

Synthesis and evaluation of amino acid ester prodrugs of penciclovir

Enantioselective synthesis of ( R)- and ( S)-2-alkyl-1,4-butanediols via enantiomerically pure 3-alkyl-5-(menthyloxy)butyrolactones

Synthesis and anti-HIV-1 activity of a series of 1-(alkoxymethyl)-5-alkyl-6-(arylselenenyl)uracils and -2-thiouracils

Synthesis and in vitro cytotoxicity of cis-(glycolato- O, O′)-[2-substituted-(4 R,5 R)-4,5-bis(aminomethyl)-1,3-dioxolane]platinum (II)

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