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Acyclic purine phosphonate analogs as antiviral agents. Synthesis and structure-activity relationships

Journal of medicinal chemistry, 1990-04, Vol.33 (4), p.1207-1213

1990

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Synthesis of a phosphonate isostere of ganciclovir monophosphate: A highly cytomegalovirus active phosphonate nucleotide analogue

Tetrahedron letters, 1990, Vol.31 (23), p.3257-3260

1990

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SYNTHESIS AND IN VITRO ACTIVITY OF C-2 QUATERNARY HETEROCYCLIC ALKYLTHIO CARBAPENEMS

The Journal of Antibiotics, 1987/12/25, Vol.40(12), pp.1707-1715

1987

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A synthesis of a spirocyclopropane-1,1'-carbapenem

Heterocycles, 1987-05, Vol.26 (5), p.1193-1196

1987

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Facile, highly stereoselective synthesis of 2′,3′-dideoxy- and 2′,3′-didehydro-2′,3t'-dideoxy nucleosides via a furanoid glycal intermediate

Tetrahedron letters, 1992-09, Vol.33 (39), p.5733-5736

1992

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Me3Al-TMSOSO2CF3 a new reagent for conversion of carbonyl to geminal dimethyl functionality : regiospecific synthesis of alkylated a ring of arotinoids

Tetrahedron letters, 1994-05, Vol.35 (19), p.3017-3020

1994

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A facile synthesis of 1-hydroxy-2- phosphonocyclobutenedione

Tetrahedron letters, 1992-07, Vol.33 (28), p.3961-3962

1992

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A new class of acyclic phosphonate nucleotide analogs: Phosphonate isosteres of acyclovir and ganciclovir monophosphates as antiviral agents

Journal of medicinal chemistry, 1991-07, Vol.34 (7), p.2286-2294

1991

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Synthesis and influenza neuraminidase inhibitory activity of aromatic analogues of sialic acid

Bioorganic & medicinal chemistry letters, 1995-10, Vol.5 (19), p.2251-2254

1995

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Regiospecific and highly stereoselective electrophilic addition to furanoid glycals: synthesis of phosphonate nucleotide analogs with potent activity against HIV

Journal of organic chemistry, 1991-04, Vol.56 (8), p.2642-2647

1991

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Stereoselective synthesis of 1-β-methylcarbapenem

Tetrahedron letters, 1987, Vol.28 (5), p.507-510

1987

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A novel synthesis of 1-OXA-HPMPA: a potent antiviral agent against herpesviruses

Tetrahedron letters, 1992, Vol.33 (1), p.25-28

1992

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(2R, 4S, 5S)-1-(tetrahydro-4-hydroxy-5-methoxy-2-furanyl)thymine: a potent selective inhibitor of herpes simplex thymidine kinase

Bioorganic & medicinal chemistry letters, 1993-08, Vol.3 (8), p.1571-1576

1993

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Novel synthesis of quinolone-3-sulfonic acid derivatives

Heterocycles, 1988, Vol.27 (5), p.1119-1122

1988

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Synthesis of a phosphonate isostere of acyclovir monophosphate : a herpesvirus active phosphonate nucleotide analogue

Heterocycles, 1990-09, Vol.31 (9), p.1571-1574

1990

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Synthesis of 9-[(Phosphonomethoxy)methyl]guanine and 9-[2-Hydroxy-1-(phosphonomethoxy)ethyl]guanine

Nucleosides & nucleotides, 1990-06, Vol.9 (4), p.579-585

1990

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Phosphonate Isosteres of 2′,3′-Didehydro-2,3-dideoxynucleoside Monophosphates: Synthesis and Anti-HIV Activity

Nucleosides & nucleotides, 1991-01, Vol.10 (1-3), p.371-375

1991

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“Me 3Al-TMSOSO 2CF 3” A new reagent for conversion of carbonyl to geminal dimethyl functionality: Regiospecific synthesis of alkylated A ring of arotinoids

Tetrahedron letters, 1994, Vol.35 (19), p.3017-3020

1994

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Synthesis and HIV activity of phosphonate isosteres of D4T monophosphate

Bioorganic & medicinal chemistry letters, 1992, Vol.2 (5), p.367-370

1992

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Facile, highly stereoselective synthesis of 2',3'-dideoxy- and 2',3'-didehydro-2',3'-dideoxy nucleosides via a furanoid glycal intermediate

Tetrahedron letters, 1992-09, Vol.33 (39), p.5733-5736

1992

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Synthesis and antiviral activity of (S)-9-(4-hydroxy-3-(phosphonomethoxy) butyl)guanine

Journal of medicinal chemistry, 1990-01, Vol.33 (6), p.1797-1800

1990

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Synthesis and anti-HIV activity of 9-[(2R-5R)-2,5-dihydro-5-(phosphonomethoxy)-2-furanyl]-2,6-diaminopurine

Bioorganic & medicinal chemistry letters, 1992, Vol.2 (4), p.307-310

1992

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Synthesis and antiviral activity of (S)-9-[4-hydroxy-3-(phosphonomethoxy)butyl]guanine

Journal of medicinal chemistry, 1990-06, Vol.33 (6), p.1797-1800

1990

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Synthesis of a Phosphonate Isostere of Acycylovir Monophosphate: A Herpesvirus Active Phosphonate Nucleotide Analogue

Heterocycles, 1990, Vol.31 (9), p.1571

1990

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Synthesis and in vitro activity of 1β-methyl C-2 quaternary heterocyclic alkylthio carbapenems

Journal of medicinal chemistry, 1989-03, Vol.32 (3), p.601-604

1989

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Acyclic purine phosphonate analogs as antiviral agents. Synthesis and structure-activity relationships

Synthesis of a phosphonate isostere of ganciclovir monophosphate: A highly cytomegalovirus active phosphonate nucleotide analogue

SYNTHESIS AND IN VITRO ACTIVITY OF C-2 QUATERNARY HETEROCYCLIC ALKYLTHIO CARBAPENEMS

A synthesis of a spirocyclopropane-1,1'-carbapenem

Facile, highly stereoselective synthesis of 2′,3′-dideoxy- and 2′,3′-didehydro-2′,3t'-dideoxy nucleosides via a furanoid glycal intermediate

Me3Al-TMSOSO2CF3 a new reagent for conversion of carbonyl to geminal dimethyl functionality : regiospecific synthesis of alkylated a ring of arotinoids

A facile synthesis of 1-hydroxy-2- phosphonocyclobutenedione

A new class of acyclic phosphonate nucleotide analogs: Phosphonate isosteres of acyclovir and ganciclovir monophosphates as antiviral agents

Synthesis and influenza neuraminidase inhibitory activity of aromatic analogues of sialic acid

Regiospecific and highly stereoselective electrophilic addition to furanoid glycals: synthesis of phosphonate nucleotide analogs with potent activity against HIV

Stereoselective synthesis of 1-β-methylcarbapenem

A novel synthesis of 1-OXA-HPMPA: a potent antiviral agent against herpesviruses

(2R, 4S, 5S)-1-(tetrahydro-4-hydroxy-5-methoxy-2-furanyl)thymine: a potent selective inhibitor of herpes simplex thymidine kinase

Novel synthesis of quinolone-3-sulfonic acid derivatives

Synthesis of a phosphonate isostere of acyclovir monophosphate : a herpesvirus active phosphonate nucleotide analogue

Synthesis of 9-[(Phosphonomethoxy)methyl]guanine and 9-[2-Hydroxy-1-(phosphonomethoxy)ethyl]guanine

Phosphonate Isosteres of 2′,3′-Didehydro-2,3-dideoxynucleoside Monophosphates: Synthesis and Anti-HIV Activity

“Me 3Al-TMSOSO 2CF 3” A new reagent for conversion of carbonyl to geminal dimethyl functionality: Regiospecific synthesis of alkylated A ring of arotinoids

Synthesis and HIV activity of phosphonate isosteres of D4T monophosphate

Facile, highly stereoselective synthesis of 2',3'-dideoxy- and 2',3'-didehydro-2',3'-dideoxy nucleosides via a furanoid glycal intermediate

Synthesis and antiviral activity of (S)-9-(4-hydroxy-3-(phosphonomethoxy) butyl)guanine

Synthesis and anti-HIV activity of 9-[(2R-5R)-2,5-dihydro-5-(phosphonomethoxy)-2-furanyl]-2,6-diaminopurine

Synthesis and antiviral activity of (S)-9-[4-hydroxy-3-(phosphonomethoxy)butyl]guanine

Synthesis of a Phosphonate Isostere of Acycylovir Monophosphate: A Herpesvirus Active Phosphonate Nucleotide Analogue

Synthesis and in vitro activity of 1β-methyl C-2 quaternary heterocyclic alkylthio carbapenems

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