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Pluripotent Stem Cell-Derived Human Liver Organoids Enter the Realm of High-Throughput Drug Screening

Gastroenterology (New York, N.Y. 1943), 2021-02, Vol.160 (3), p.653-655

Khetani, Salman R.

2021

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Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes

Toxicological sciences, 2015-06, Vol.145 (2), p.252-262

2015

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Microscale culture of human liver cells for drug development

Nature biotechnology, 2008-01, Vol.26 (1), p.120-126

2008

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Bioengineered Liver Models for Drug Testing and Cell Differentiation Studies

Cellular and molecular gastroenterology and hepatology, 2018-01, Vol.5 (3), p.426-439.e1

2018

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The Role of Liver Zonation in Physiology, Regeneration, and Disease

Seminars in liver disease, 2022-02, Vol.42 (1), p.1-16

2022

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Advances in Engineered Human Liver Platforms for Drug Metabolism Studies

Drug metabolism and disposition, 2018-11, Vol.46 (11), p.1626-1637

2018

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Engineered Liver Platforms for Different Phases of Drug Development

Trends in biotechnology (Regular ed.), 2017-02, Vol.35 (2), p.172-183

2017

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Advances in Engineered Liver Models for Investigating Drug-Induced Liver Injury

BioMed research international, 2016-01, Vol.2016 (2016), p.1-20

2016

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Enhancing the functional maturity of induced pluripotent stem cell–derived human hepatocytes by controlled presentation of cell–cell interactions in vitro

Hepatology (Baltimore, Md.), 2015-04, Vol.61 (4), p.1370-1381

2015

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Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac

Drug metabolism and disposition, 2013-12, Vol.41 (12), p.2024-2032

2013

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Superhydrophobic Coatings with Edible Materials

ACS applied materials & interfaces, 2016-07, Vol.8 (29), p.18664-18668

2016

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Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes

Scientific reports, 2016-06, Vol.6 (1), p.28178-28178, Article 28178

2016

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Physiologically inspired culture medium prolongs the lifetime and insulin sensitivity of human hepatocytes in micropatterned co-cultures

Toxicology (Amsterdam), 2021-02, Vol.449, p.152662-152662, Article 152662

2021

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Intermittent Starvation Extends the Functional Lifetime of Primary Human Hepatocyte Cultures

Toxicological sciences, 2020-04, Vol.174 (2), p.266-277

2020

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Prediction of Drug Clearance and Drug-Drug Interactions in Microscale Cultures of Human Hepatocytes

Drug metabolism and disposition, 2016-01, Vol.44 (1), p.127-136

2016

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Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans

Toxicological sciences, 2013-03, Vol.132 (1), p.107-117

2013

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Establishment of a hepatocyte-kupffer cell coculture model for assessment of proinflammatory cytokine effects on metabolizing enzymes and drug transporters

Drug metabolism and disposition, 2015-05, Vol.43 (5), p.774-785

2015

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Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens

Nature protocols, 2015-12, Vol.10 (12), p.2027-2053

2015

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Bioengineered Liver Models for Investigating Disease Pathogenesis and Regenerative Medicine

Seminars in liver disease, 2021-08, Vol.41 (3), p.368-392

2021

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Microfabrication of liver and heart tissues for drug development

Philosophical transactions of the Royal Society of London. Series B. Biological sciences, 2018-07, Vol.373 (1750), p.20170225

2018

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Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity

Hepatology (Baltimore, Md.), 2021-12, Vol.74 (6), p.3486-3496

2021

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Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac

Drug metabolism and disposition, 2019-01, Vol.47 (1), p.58-66

2019

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Hepatitis C Virus Infection Induces Autocrine Interferon Signaling by Human Liver Endothelial Cells and Release of Exosomes, Which Inhibits Viral Replication

Gastroenterology (New York, N.Y. 1943), 2015-02, Vol.148 (2), p.392-402.e13

2015

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Modulation of human iPSC-derived hepatocyte phenotype via extracellular matrix microarrays

Acta biomaterialia, 2022-11, Vol.153, p.216-230

2022

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Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites

Drug metabolism and disposition, 2010-10, Vol.38 (10), p.1900-1905

2010

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Pluripotent Stem Cell-Derived Human Liver Organoids Enter the Realm of High-Throughput Drug Screening

Prediction of Drug-Induced Liver Injury in Micropatterned Co-cultures Containing iPSC-Derived Human Hepatocytes

Microscale culture of human liver cells for drug development

Bioengineered Liver Models for Drug Testing and Cell Differentiation Studies

The Role of Liver Zonation in Physiology, Regeneration, and Disease

Advances in Engineered Human Liver Platforms for Drug Metabolism Studies

Engineered Liver Platforms for Different Phases of Drug Development

Advances in Engineered Liver Models for Investigating Drug-Induced Liver Injury

Enhancing the functional maturity of induced pluripotent stem cell–derived human hepatocytes by controlled presentation of cell–cell interactions in vitro

Meeting the challenge of predicting hepatic clearance of compounds slowly metabolized by cytochrome P450 using a novel hepatocyte model, HepatoPac

Superhydrophobic Coatings with Edible Materials

Long-term exposure to abnormal glucose levels alters drug metabolism pathways and insulin sensitivity in primary human hepatocytes

Physiologically inspired culture medium prolongs the lifetime and insulin sensitivity of human hepatocytes in micropatterned co-cultures

Intermittent Starvation Extends the Functional Lifetime of Primary Human Hepatocyte Cultures

Prediction of Drug Clearance and Drug-Drug Interactions in Microscale Cultures of Human Hepatocytes

Use of micropatterned cocultures to detect compounds that cause drug-induced liver injury in humans

Establishment of a hepatocyte-kupffer cell coculture model for assessment of proinflammatory cytokine effects on metabolizing enzymes and drug transporters

Micropatterned coculture of primary human hepatocytes and supportive cells for the study of hepatotropic pathogens

Bioengineered Liver Models for Investigating Disease Pathogenesis and Regenerative Medicine

Microfabrication of liver and heart tissues for drug development

Key Characteristics of Human Hepatotoxicants as a Basis for Identification and Characterization of the Causes of Liver Toxicity

Meeting the Challenge of Predicting Hepatic Clearance of Compounds Slowly Metabolized by Cytochrome P450 Using a Novel Hepatocyte Model, HepatoPac

Hepatitis C Virus Infection Induces Autocrine Interferon Signaling by Human Liver Endothelial Cells and Release of Exosomes, Which Inhibits Viral Replication

Modulation of human iPSC-derived hepatocyte phenotype via extracellular matrix microarrays

Assessment of a micropatterned hepatocyte coculture system to generate major human excretory and circulating drug metabolites

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