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Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992

Molecular pharmacology, 2018-08, Vol.94 (2), p.926-937

2018

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VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels

Molecular pharmacology, 2022-05, Vol.101 (5), p.357-370

2022

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The β3 Subunit Contributes to Vascular Calcium Channel Upregulation and Hypertension in Angiotensin II–Infused C57BL/6 Mice

Hypertension (Dallas, Tex. 1979), 2013-01, Vol.61 (1), p.137-142

2013

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Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels

ACS chemical neuroscience, 2019-01, Vol.10 (1), p.358-370

2019

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The LRRC8 volume‐regulated anion channel inhibitor, DCPIB, inhibits mitochondrial respiration independently of the channel

Physiological reports, 2019-12, Vol.7 (23), p.e14303-n/a

2019

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A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function

Proceedings of the National Academy of Sciences - PNAS, 2023-01, Vol.120 (4), p.e2212338120-e2212338120

2023

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Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063

The Journal of pharmacology and experimental therapeutics, 2019-09, Vol.370 (3), p.350

2019

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Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590

Molecular pharmacology, 2017-09, Vol.92 (3), p.338-346

2017

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BK Channels in Rat and Human Pulmonary Smooth Muscle Cells are BKα-β1 Functional Complexes Lacking the Oxygen-Sensitive Stress Axis Regulated Exon Insert

Pulmonary circulation, 2016-12, Vol.6 (4), p.563-575

2016

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The shifting landscape of K ATP channelopathies and the need for ‘sharper’ therapeutics

Future medicinal chemistry, 2016-05, Vol.8 (7), p.789-802

2016

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The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics

Future medicinal chemistry, 2016-05, Vol.8 (7), p.789-802

2016

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ROMK inhibitor actions in the nephron probed with diuretics

American journal of physiology. Renal physiology, 2016-04, Vol.310 (8), p.F732-F737

2016

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Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics

Current opinion in pharmacology, 2014-04, Vol.15, p.7-15

2014

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Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes aegypti Kir1 (AeKir) Channel and Larvicides

ChemMedChem, 2021-01, Vol.16 (2), p.319-327

2021

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Plight of the pore polar bar(rier)

Channels (Austin, Tex.), 2017-11, Vol.11 (6), p.502-503

2017

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ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels

ACS chemical neuroscience, 2016-07, Vol.7 (7), p.1013-1023

2016

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Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity

Evidence-based complementary and alternative medicine, 2015-01, Vol.2015, p.148791-9

2015

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ROMK (Kir1.1) pharmacology comes of age

Channels (Austin, Tex.), 2015-05, Vol.9 (3), p.119-120

2015

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Discovery and Characterization of 2‑Nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)‑N‑(pyridin-4-ylmethyl)anilines as Novel Inhibitors of the Aedes aegypti Kir1 (AeKir1) Channel

ACS infectious diseases, 2019-06, Vol.5 (6), p.917-931

2019

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Intracellular Ca2+ Silences L-Type Ca2+ Channels in Mesenteric Veins: Mechanism of Venous Smooth Muscle Resistance to Calcium Channel Blockers

Circulation research, 2010-03, Vol.106 (4), p.739-747

2010

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Discovery and in Vitro Optimization of 3‑Sulfamoylbenzamides as ROMK Inhibitors

ACS medicinal chemistry letters, 2018-02, Vol.9 (2), p.125-130

2018

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Mrg19 depletion increases S. cerevisiae lifespan by augmenting ROS defence

FEBS letters, 2005-12, Vol.579 (30), p.6809-6813

2005

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Development of novel therapeutics for treating edema and SeSAME/EAST syndrome targeting heteromeric Kir4.1/5.1 potassium channels

The FASEB journal, 2020-04, Vol.34 (S1), p.1-1

2020

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BK channels in rat and human pulmonary smooth muscle cells are BKα-β 1 functional complexes lacking the oxygen-sensitive stress axis regulated exon insert

Pulmonary circulation, 2016-12, Vol.6 (4), p.563-575

2016

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VU590 inhibits Kir1.1 and Kir7.1 potassium channels through distinct molecular mechanisms

The FASEB journal, 2017-04, Vol.31 (S1)

2017

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Discovery, Characterization, and Effects on Renal Fluid and Electrolyte Excretion of the Kir4.1 Potassium Channel Pore Blocker, VU0134992

VU6036720: The First Potent and Selective In Vitro Inhibitor of Heteromeric Kir4.1/5.1 Inward Rectifier Potassium Channels

The β3 Subunit Contributes to Vascular Calcium Channel Upregulation and Hypertension in Angiotensin II–Infused C57BL/6 Mice

Discovery and Characterization of VU0529331, a Synthetic Small-Molecule Activator of Homomeric G Protein-Gated, Inwardly Rectifying, Potassium (GIRK) Channels

The LRRC8 volume‐regulated anion channel inhibitor, DCPIB, inhibits mitochondrial respiration independently of the channel

A selective inhibitor of the sperm-specific potassium channel SLO3 impairs human sperm function

Structure-Activity Relationships, Pharmacokinetics, and Pharmacodynamics of the Kir6.2/SUR1-Specific Channel Opener VU0071063

Pore Polarity and Charge Determine Differential Block of Kir1.1 and Kir7.1 Potassium Channels by Small-Molecule Inhibitor VU590

BK Channels in Rat and Human Pulmonary Smooth Muscle Cells are BKα-β1 Functional Complexes Lacking the Oxygen-Sensitive Stress Axis Regulated Exon Insert

The shifting landscape of K ATP channelopathies and the need for ‘sharper’ therapeutics

The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics

ROMK inhibitor actions in the nephron probed with diuretics

Cardiac and renal inward rectifier potassium channel pharmacology: emerging tools for integrative physiology and therapeutics

Further SAR on the (Phenylsulfonyl)piperazine Scaffold as Inhibitors of the Aedes aegypti Kir1 (AeKir) Channel and Larvicides

Plight of the pore polar bar(rier)

ML418: The First Selective, Sub-Micromolar Pore Blocker of Kir7.1 Potassium Channels

Tocotrienol-Rich Fraction from Rice Bran Demonstrates Potent Radiation Protection Activity

ROMK (Kir1.1) pharmacology comes of age

Discovery and Characterization of 2‑Nitro-5-(4-(phenylsulfonyl)piperazin-1-yl)‑N‑(pyridin-4-ylmethyl)anilines as Novel Inhibitors of the Aedes aegypti Kir1 (AeKir1) Channel

Intracellular Ca2+ Silences L-Type Ca2+ Channels in Mesenteric Veins: Mechanism of Venous Smooth Muscle Resistance to Calcium Channel Blockers

Discovery and in Vitro Optimization of 3‑Sulfamoylbenzamides as ROMK Inhibitors

Mrg19 depletion increases S. cerevisiae lifespan by augmenting ROS defence

Development of novel therapeutics for treating edema and SeSAME/EAST syndrome targeting heteromeric Kir4.1/5.1 potassium channels

BK channels in rat and human pulmonary smooth muscle cells are BKα-β 1 functional complexes lacking the oxygen-sensitive stress axis regulated exon insert

VU590 inhibits Kir1.1 and Kir7.1 potassium channels through distinct molecular mechanisms

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