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Drug discovery in pharmaceutical industry: productivity challenges and trends

Drug discovery today, 2012-10, Vol.17 (19-20), p.1088-1102

Khanna, Ish

2012

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Buprenorphine - an attractive opioid with underutilized potential in treatment of chronic pain

Journal of Pain Research, 2015-01, Vol.8 (Issue 1), p.859-870

2015

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A multimodal disease modifying approach to treat neuropathic pain – inhibition of soluble epoxide hydrolase (sEH)

Drug discovery today, 2015-11, Vol.20 (11), p.1382-1390

2015

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Fatty acid amide hydrolase inhibitors--progress and potential

CNS & neurological disorders drug targets, 2011-08, Vol.10 (5), p.545

2011

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An AMPK activator as a therapeutic option for congenital nephrogenic diabetes insipidus

JCI insight, 2021-04, Vol.6 (8)

2021

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Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists

Bioorganic & medicinal chemistry letters, 2012-05, Vol.22 (9), p.3157-3162

2012

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Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Part 2

Bioorganic & medicinal chemistry letters, 2012-05, Vol.22 (9), p.3163-3167

2012

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A multimodal disease modifying approach to treat neuropathic pain - inhibition of soluble epoxide hydrolase (sEH): Post screen

Drug discovery today, 2015-11, Vol.20 (11), p.1382-1390

2015

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1,2-Diarylimidazoles as Potent, Cyclooxygenase-2 Selective, and Orally Active Antiinflammatory Agents

Journal of medicinal chemistry, 1997-05, Vol.40 (11), p.1634-1647

1997

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1,2-Diarylpyrroles as Potent and Selective Inhibitors of Cyclooxygenase-2

Journal of medicinal chemistry, 1997-05, Vol.40 (11), p.1619-1633

1997

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Discovery of + (2 -{4 -[2 -(5,6,7,8 -tetrahydro -1,8 -naphthyridin -2-yl )ethoxy ]phenyl} -cyclopropyl )acetic acid as potent and selective αvβ3 inhibitor : Design, synthesis, and optimization

Bioorganic & medicinal chemistry, 2007-05, Vol.15 (10), p.3390-3412

2007

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Pain and beyond: fatty acid amides and fatty acid amide hydrolase inhibitors in cardiovascular and metabolic diseases

Drug discovery today, 2009-12, Vol.14 (23-24), p.1098-1111

2009

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Targeting soluble epoxide hydrolase for inflammation and pain - an overview of pharmacology and the inhibitors

Inflammation & allergy drug targets, 2012-04, Vol.11 (2), p.143

2012

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Facile, Regioselective Syntheses of N-Alkylated 2,3-Diaminopyridines and Imidazo[4,5-b]pyridines

Journal of organic chemistry, 1995-02, Vol.60 (4), p.960-965

1995

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Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists

Bioorganic & medicinal chemistry letters, 2015-02, Vol.25 (4), p.887-892

2015

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Discovery of novel, orally available benzimidazoles as melanin concentrating hormone receptor 1 (MCHR1) antagonists

Bioorganic & medicinal chemistry letters, 2010-09, Vol.20 (18), p.5443-5448

2010

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Selective Cyclooxygenase-2 Inhibitors: Heteroaryl Modified 1,2-Diarylimidazoles Are Potent, Orally Active Antiinflammatory Agents

Journal of medicinal chemistry, 2000-08, Vol.43 (16), p.3168-3185

2000

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Synthesis and SAR studies of benzimidazole derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Focus to detune hERG inhibition

MedChemComm, 2011-05, Vol.2 (5), p.385

2011

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Chapter 12 Recent Trends in HDL Modulating Therapies

Annual Reports in Medicinal Chemistry, 2007, Vol.42, p.177-191

2007

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Antimicrobial agents from higher plants: Prenylated flavonoids and other phenols from Glycyrrhiza lepidota

Phytochemistry (Oxford), 1983, Vol.22 (2), p.573-576

1983

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Drug discovery in pharmaceutical industry: productivity challenges and trends

Buprenorphine - an attractive opioid with underutilized potential in treatment of chronic pain

A multimodal disease modifying approach to treat neuropathic pain – inhibition of soluble epoxide hydrolase (sEH)

Fatty acid amide hydrolase inhibitors--progress and potential

An AMPK activator as a therapeutic option for congenital nephrogenic diabetes insipidus

Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists

Design and optimization of quinazoline derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Part 2

A multimodal disease modifying approach to treat neuropathic pain - inhibition of soluble epoxide hydrolase (sEH): Post screen

1,2-Diarylimidazoles as Potent, Cyclooxygenase-2 Selective, and Orally Active Antiinflammatory Agents

1,2-Diarylpyrroles as Potent and Selective Inhibitors of Cyclooxygenase-2

Convergent, parallel synthesis of a series of β-substituted 1,2,4-oxadiazole butanoic acids as potent and selective αvβ3 receptor antagonists

Discovery of + (2 -{4 -[2 -(5,6,7,8 -tetrahydro -1,8 -naphthyridin -2-yl )ethoxy ]phenyl} -cyclopropyl )acetic acid as potent and selective αvβ3 inhibitor : Design, synthesis, and optimization

Pain and beyond: fatty acid amides and fatty acid amide hydrolase inhibitors in cardiovascular and metabolic diseases

Targeting soluble epoxide hydrolase for inflammation and pain - an overview of pharmacology and the inhibitors

Facile, Regioselective Syntheses of N-Alkylated 2,3-Diaminopyridines and Imidazo[4,5-b]pyridines

Optimisation of in silico derived 2-aminobenzimidazole hits as unprecedented selective kappa opioid receptor agonists

Discovery of novel, orally available benzimidazoles as melanin concentrating hormone receptor 1 (MCHR1) antagonists

Selective Cyclooxygenase-2 Inhibitors: Heteroaryl Modified 1,2-Diarylimidazoles Are Potent, Orally Active Antiinflammatory Agents

Synthesis and SAR studies of benzimidazole derivatives as melanin concentrating hormone receptor 1 (MCHR1) antagonists: Focus to detune hERG inhibition

Chapter 12 Recent Trends in HDL Modulating Therapies

Antimicrobial agents from higher plants: Prenylated flavonoids and other phenols from Glycyrrhiza lepidota

Discovery of +(2-{4-[2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethoxy]phenyl}-cyclopropyl)acetic acid as potent and selective α vβ 3 inhibitor: Design, synthesis, and optimization

Convergent, parallel synthesis of a series of beta-substituted 1,2,4-oxadiazole butanoic acids as potent and selective alpha(v)beta3 receptor antagonists

Convergent, parallel synthesis of a series of beta -substituted 1,2,4- oxadiazole butanoic acids as potent and selective alpha sub(v) beta sub(3) receptor antagonists

Convergent, parallel synthesis of a series of β-substituted 1,2,4-oxadiazole butanoic acids as potent and selective α vβ 3 receptor antagonists

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