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Stellate cells are in utero markers of pancreatic disease in cystic fibrosis

Molecular medicine (Cambridge, Mass.), 2024-08, Vol.30 (1), p.115-29, Article 115

2024

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Investigating adverse genomic and regulatory changes caused by replacement of the full-length CFTR cDNA using Cas9 and AAV

Molecular therapy. Nucleic acids, 2024-03, Vol.35 (1), p.102134, Article 102134

2024

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The impact of genomic distance on enhancer‐promoter interactions at the CFTR locus

Journal of cellular and molecular medicine, 2024-02, Vol.28 (4), p.e18142-n/a

2024

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Cellular heterogeneity in the 16HBE14o− airway epithelial line impacts biological readouts

Physiological reports, 2023-06, Vol.11 (11), p.e15700-n/a

2023

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Transcriptomic analysis of lung development in wildtype and CFTR−/− sheep suggests an early inflammatory signature in the CF distal lung

Functional & integrative genomics, 2023-06, Vol.23 (2), p.135-135, Article 135

2023

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An ectopic enhancer restores CFTR expression through de novo chromatin looping

Gene therapy, 2023-06, Vol.30 (6), p.478-486

2023

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Early developmental phenotypes in the cystic fibrosis sheep model

FASEB bioAdvances, 2023-01, Vol.5 (1), p.13-26

2023

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Cell function and identity revealed by comparative scRNA-seq analysis in human nasal, bronchial and epididymis epithelia

European journal of cell biology, 2022-06, Vol.101 (3), p.151231-151231, Article 151231

2022

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OTX2 regulates CFTR expression during endoderm differentiation and occupies 3′ cis‐regulatory elements

Developmental dynamics, 2021-05, Vol.250 (5), p.684-700

2021

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An atlas of human proximal epididymis reveals cell-specific functions and distinct roles for CFTR

Life science alliance, 2020-11, Vol.3 (11), p.e202000744

2020

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A functional genomics approach to investigate the differentiation of iPSCs into lung epithelium at air‐liquid interface

Journal of cellular and molecular medicine, 2020-09, Vol.24 (17), p.9853-9870

2020

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An organoid model to assay the role of CFTR in the human epididymis epithelium

Cell and tissue research, 2020-08, Vol.381 (2), p.327-336

2020

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Highly Efficient Gene Editing of Cystic Fibrosis Patient-Derived Airway Basal Cells Results in Functional CFTR Correction

Molecular therapy, 2020-07, Vol.28 (7), p.1684-1695

2020

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Functional genomics analysis of human colon organoids identifies key transcription factors

Physiological genomics, 2020-06, Vol.52 (6), p.234-244

2020

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Looping of upstream cis-regulatory elements is required for CFTR expression in human airway epithelial cells

Nucleic acids research, 2020-04, Vol.48 (7), p.3513-3524

2020

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Coordinate regulation of ELF5 and EHF at the chr11p13 CF modifier region

Journal of cellular and molecular medicine, 2019-11, Vol.23 (11), p.7726-7740

2019

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Screening for Regulatory Variants in 460 kb Encompassing the CFTR Locus in Cystic Fibrosis Patients

The Journal of molecular diagnostics : JMD, 2019-01, Vol.21 (1), p.70-80

2019

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Casein Kinase II Phosphorylation of Spt6 Enforces Transcriptional Fidelity by Maintaining Spn1-Spt6 Interaction

Cell reports (Cambridge), 2018-12, Vol.25 (12), p.3476-3489.e5

2018

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Regulatory dynamics of 11p13 suggest a role for EHF in modifying CF lung disease severity

Nucleic acids research, 2017-09, Vol.45 (15), p.8773-8784

2017

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Quantitative Analysis of Dynamic Protein Interactions during Transcription Reveals a Role for Casein Kinase II in Polymerase-associated Factor (PAF) Complex Phosphorylation and Regulation of Histone H2B Monoubiquitylation

The Journal of biological chemistry, 2016-06, Vol.291 (26), p.13410-13420

2016

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Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus

Nucleic acids research, 2016-04, Vol.44 (7), p.3082-3094

2016

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Hepatocyte nuclear factor 1 coordinates multiple processes in a model of intestinal epithelial cell function

Biochimica et biophysica acta, 2016-04, Vol.1859 (4), p.591-598

2016

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Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response

Genes & development, 2015-09, Vol.29 (17), p.1795-1800

2015

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FOXA2 regulates a network of genes involved in critical functions of human intestinal epithelial cells

Physiological genomics, 2015-07, Vol.47 (7), p.290-297

2015

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Architectural proteins CTCF and cohesin have distinct roles in modulating the higher order structure and expression of the CFTR locus

Nucleic acids research, 2014-09, Vol.42 (15), p.9612-9622

2014

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Stellate cells are in utero markers of pancreatic disease in cystic fibrosis

Investigating adverse genomic and regulatory changes caused by replacement of the full-length CFTR cDNA using Cas9 and AAV

The impact of genomic distance on enhancer‐promoter interactions at the CFTR locus

Cellular heterogeneity in the 16HBE14o− airway epithelial line impacts biological readouts

Transcriptomic analysis of lung development in wildtype and CFTR−/− sheep suggests an early inflammatory signature in the CF distal lung

An ectopic enhancer restores CFTR expression through de novo chromatin looping

Early developmental phenotypes in the cystic fibrosis sheep model

Cell function and identity revealed by comparative scRNA-seq analysis in human nasal, bronchial and epididymis epithelia

OTX2 regulates CFTR expression during endoderm differentiation and occupies 3′ cis‐regulatory elements

An atlas of human proximal epididymis reveals cell-specific functions and distinct roles for CFTR

A functional genomics approach to investigate the differentiation of iPSCs into lung epithelium at air‐liquid interface

An organoid model to assay the role of CFTR in the human epididymis epithelium

Highly Efficient Gene Editing of Cystic Fibrosis Patient-Derived Airway Basal Cells Results in Functional CFTR Correction

Functional genomics analysis of human colon organoids identifies key transcription factors

Looping of upstream cis-regulatory elements is required for CFTR expression in human airway epithelial cells

Coordinate regulation of ELF5 and EHF at the chr11p13 CF modifier region

Screening for Regulatory Variants in 460 kb Encompassing the CFTR Locus in Cystic Fibrosis Patients

Casein Kinase II Phosphorylation of Spt6 Enforces Transcriptional Fidelity by Maintaining Spn1-Spt6 Interaction

Regulatory dynamics of 11p13 suggest a role for EHF in modifying CF lung disease severity

Quantitative Analysis of Dynamic Protein Interactions during Transcription Reveals a Role for Casein Kinase II in Polymerase-associated Factor (PAF) Complex Phosphorylation and Regulation of Histone H2B Monoubiquitylation

Differential contribution of cis-regulatory elements to higher order chromatin structure and expression of the CFTR locus

Hepatocyte nuclear factor 1 coordinates multiple processes in a model of intestinal epithelial cell function

Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response

FOXA2 regulates a network of genes involved in critical functions of human intestinal epithelial cells

Architectural proteins CTCF and cohesin have distinct roles in modulating the higher order structure and expression of the CFTR locus

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