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Mechanism of Quinolone Action and Resistance

Biochemistry (Easton), 2014-03, Vol.53 (10), p.1565-1574

2014

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Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes from Mycobacterium tuberculosis

Proceedings of the National Academy of Sciences - PNAS, 2016-02, Vol.113 (7), p.1706-1713

2016

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Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase

Proceedings of the National Academy of Sciences - PNAS, 2016-02, Vol.113 (7), p.E839-E846

2016

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Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance

Nucleic acids research, 2013-04, Vol.41 (8), p.4628-4639

2013

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Role of the Water-Metal Ion Bridge in Quinolone Interactions with Escherichia coli Gyrase

International journal of molecular sciences, 2023-02, Vol.24 (3), p.2879

2023

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Overcoming Target-Mediated Quinolone Resistance in Topoisomerase IV by Introducing Metal-Ion-Independent Drug–Enzyme Interactions

ACS chemical biology, 2013-12, Vol.8 (12), p.2660-2668

2013

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Bioenergetic effects of mitochondrial-targeted coenzyme Q analogs in endothelial cells

The Journal of pharmacology and experimental therapeutics, 2012-09, Vol.342 (3), p.709-719

2012

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Fluoroquinolone and Quinazolinedione Activities against Wild-Type and Gyrase Mutant Strains of Mycobacterium smegmatis

Antimicrobial Agents and Chemotherapy, 2011-05, Vol.55 (5), p.2335-2343

2011

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Factors Affecting Stereocontrol during Glycosidation of 2,3-Oxazolidinone-Protected 1-Tolylthio-N-acetyl-d-glucosamine

Journal of organic chemistry, 2005-05, Vol.70 (10), p.4195-4198

2005

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Novel Approach for Comparing the Abilities of Quinolones To Restrict the Emergence of Resistant Mutants during Quinolone Exposure

Antimicrobial Agents and Chemotherapy, 2010-01, Vol.54 (1), p.149-156

2010

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A Novel Triphenylphosphonium Carrier to Target Mitochondria without Uncoupling Oxidative Phosphorylation

Journal of medicinal chemistry, 2021-01, Vol.64 (1), p.662-676

2021

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Quinolone-Mediated Bacterial Death

Antimicrobial agents and chemotherapy, 2008-02, Vol.52 (2), p.385-392

2008

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Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats

Pharmacology research & perspectives, 2021-02, Vol.9 (1), p.e00701-n/a

2021

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Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding

The Journal of biological chemistry, 2014-05, Vol.289 (18), p.12300-12312

2014

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Use of Gyrase Resistance Mutants To Guide Selection of 8-Methoxy-Quinazoline-2,4-Diones

Antimicrobial Agents and Chemotherapy, 2008-11, Vol.52 (11), p.3915-3921

2008

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Comparison of In Vitro Activities of Fluoroquinolone-Like 2,4- and 1,3-Diones

Antimicrobial Agents and Chemotherapy, 2010-07, Vol.54 (7), p.3011-3014

2010

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Induction of Mycobacterial Resistance to Quinolone Class Antimicrobials

Antimicrobial Agents and Chemotherapy, 2012-07, Vol.56 (7), p.3879-3887

2012

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Effect of N-1/C-8 Ring Fusion and C-7 Ring Structure on Fluoroquinolone Lethality

Antimicrobial Agents and Chemotherapy, 2010-12, Vol.54 (12), p.5214-5221

2010

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N-Arylacyl O-sulfonated aminoglycosides as novel inhibitors of human neutrophil elastase, cathepsin G and proteinase 3

Glycobiology (Oxford), 2016-07, Vol.26 (7), p.701-709

2016

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Promising antimalarials targeting apicoplast DNA polymerase from Plasmodium falciparum

European journal of medicinal chemistry, 2022-12, Vol.243, p.114751-114751, Article 114751

2022

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Insulin sensitization by small molecules enhancing GLUT4 translocation

Cell chemical biology, 2023-08, Vol.30 (8), p.933-942.e6

2023

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Role of the Water–Metal Ion Bridge in Mediating Interactions between Quinolones and Escherichia coli Topoisomerase IV

Biochemistry (Easton), 2014-09, Vol.53 (34), p.5558-5567

2014

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Drug Interactions with Bacillus anthracis Topoisomerase IV: Biochemical Basis for Quinolone Action and Resistance

Biochemistry (Easton), 2012-01, Vol.51 (1), p.370-381

2012

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Stability of Phenyl-Modified Triphenylphosphonium Conjugates and Interactions with DTPA

ACS omega, 2022-12, Vol.7 (51), p.48332-48339

2022

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Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase

Bioorganic & medicinal chemistry letters, 2018-06, Vol.28 (10), p.1903-1910

2018

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Mechanism of Quinolone Action and Resistance

Crystal structure and stability of gyrase–fluoroquinolone cleaved complexes from Mycobacterium tuberculosis

Fluoroquinolone interactions with Mycobacterium tuberculosis gyrase: Enhancing drug activity against wild-type and resistant gyrase

Topoisomerase IV-quinolone interactions are mediated through a water-metal ion bridge: mechanistic basis of quinolone resistance

Role of the Water-Metal Ion Bridge in Quinolone Interactions with Escherichia coli Gyrase

Overcoming Target-Mediated Quinolone Resistance in Topoisomerase IV by Introducing Metal-Ion-Independent Drug–Enzyme Interactions

Bioenergetic effects of mitochondrial-targeted coenzyme Q analogs in endothelial cells

Fluoroquinolone and Quinazolinedione Activities against Wild-Type and Gyrase Mutant Strains of Mycobacterium smegmatis

Factors Affecting Stereocontrol during Glycosidation of 2,3-Oxazolidinone-Protected 1-Tolylthio-N-acetyl-d-glucosamine

Novel Approach for Comparing the Abilities of Quinolones To Restrict the Emergence of Resistant Mutants during Quinolone Exposure

A Novel Triphenylphosphonium Carrier to Target Mitochondria without Uncoupling Oxidative Phosphorylation

Quinolone-Mediated Bacterial Death

Effect of mitoquinone on liver metabolism and steatosis in obese and diabetic rats

Fluoroquinolone-gyrase-DNA complexes: two modes of drug binding

Use of Gyrase Resistance Mutants To Guide Selection of 8-Methoxy-Quinazoline-2,4-Diones

Comparison of In Vitro Activities of Fluoroquinolone-Like 2,4- and 1,3-Diones

Induction of Mycobacterial Resistance to Quinolone Class Antimicrobials

Effect of N-1/C-8 Ring Fusion and C-7 Ring Structure on Fluoroquinolone Lethality

N-Arylacyl O-sulfonated aminoglycosides as novel inhibitors of human neutrophil elastase, cathepsin G and proteinase 3

Promising antimalarials targeting apicoplast DNA polymerase from Plasmodium falciparum

Insulin sensitization by small molecules enhancing GLUT4 translocation

Role of the Water–Metal Ion Bridge in Mediating Interactions between Quinolones and Escherichia coli Topoisomerase IV

Drug Interactions with Bacillus anthracis Topoisomerase IV: Biochemical Basis for Quinolone Action and Resistance

Stability of Phenyl-Modified Triphenylphosphonium Conjugates and Interactions with DTPA

Design, synthesis, and evaluation of novel N-1 fluoroquinolone derivatives: Probing for binding contact with the active site tyrosine of gyrase

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