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The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

Nature reviews. Drug discovery, 2010-12, Vol.9 (12), p.929-939

2010

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Drug-Like Properties - Concepts, Structure, Design, and Methods from ADME to Toxicity Optimization (2nd Edition)

Li Di, Edward H Kerns

2, 2016

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High throughput physicochemical profiling for drug discovery

Journal of pharmaceutical sciences, 2001-11, Vol.90 (11), p.1838-1858

Kerns, Edward H.

2001

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Biological assay challenges from compound solubility: strategies for bioassay optimization

Drug discovery today, 2006-05, Vol.11 (9), p.446-451

2006

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Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

Drug discovery today, 2012-08, Vol.17 (15-16), p.905-912

2012

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Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

Molecular pharmaceutics, 2014-06, Vol.11 (6), p.1727-1738

2014

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High throughput artificial membrane permeability assay for blood–brain barrier

European journal of medicinal chemistry, 2003-03, Vol.38 (3), p.223-232

2003

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Comparison of blood–brain barrier permeability assays: in situ brain perfusion, MDR1-MDCKII and PAMPA-BBB

Journal of pharmaceutical sciences, 2009-06, Vol.98 (6), p.1980-1991

2009

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Blood-brain barrier in drug discovery: optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs

1st ed., 2014

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Development and application of high throughput plasma stability assay for drug discovery

International journal of pharmaceutics, 2005-06, Vol.297 (1), p.110-119

2005

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Quantification of cyclocreatine in mouse and rat plasma using hydrophilic-interaction ultra-performance liquid chromatography-tandem mass spectrometry

Journal of pharmaceutical and biomedical analysis, 2017-10, Vol.145, p.629-633

2017

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Combined Application of Parallel Artificial Membrane Permeability Assay and Caco-2 Permeability Assays in Drug Discovery

Journal of pharmaceutical sciences, 2004-06, Vol.93 (6), p.1440-1453

2004

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Drug-like property concepts in pharmaceutical design

Current pharmaceutical design, 2009-07, Vol.15 (19), p.2184-2194

2009

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The Critical Role of Passive Permeability in Designing Successful Drugs

ChemMedChem, 2020-10, Vol.15 (20), p.1862-1874

2020

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Utility of mass spectrometry for pharmaceutical profiling applications

Current drug metabolism, 2006-07, Vol.7 (5), p.457-466

2006

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Identification of a series of benzoxazoles as potent 5-HT6 ligands

Bioorganic & medicinal chemistry letters, 2009-02, Vol.19 (4), p.1115-1117

2009

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Pharmaceutical profiling method for lipophilicity and integrity using liquid chromatography–mass spectrometry

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences, 2003-07, Vol.791 (1), p.381-388

2003

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Profiling drug-like properties in discovery research

Current opinion in chemical biology, 2003-06, Vol.7 (3), p.402-408

2003

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Pharmaceutical profiling in drug discovery

Drug Discovery Today, 2003-04, Vol.8 (7), p.316-323

2003

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Synthesis and Structure–Activity Relationship Studies of 4‑((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase

Journal of medicinal chemistry, 2014-01, Vol.57 (2), p.495-506

2014

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In vitro solubility assays in drug discovery

Current drug metabolism, 2008-11, Vol.9 (9), p.879-885

2008

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Synthesis and Structure–Activity Relationship Studies of N‑Benzyl-2-phenylpyrimidin-4-amine Derivatives as Potent USP1/UAF1 Deubiquitinase Inhibitors with Anticancer Activity against Nonsmall Cell Lung Cancer

Journal of medicinal chemistry, 2014-10, Vol.57 (19), p.8099-8110

2014

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Hybrid triple quadrupole-linear ion trap mass spectrometry in fragmentation mechanism studies: application to structure elucidation of buspirone and one of its metabolites

Journal of mass spectrometry., 2005-08, Vol.40 (8), p.1017-1029

2005

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Insights for Predicting Blood-Brain Barrier Penetration of CNS Targeted Molecules Using QSPR Approaches

Journal of chemical information and modeling, 2010-06, Vol.50 (6), p.1123-1133

2010

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Strategies to assess blood-brain barrier penetration

Expert opinion on drug discovery, 2008-06, Vol.3 (6), p.677-687

2008

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The effect of plasma protein binding on in vivo efficacy: misconceptions in drug discovery

Drug-Like Properties - Concepts, Structure, Design, and Methods from ADME to Toxicity Optimization (2nd Edition)

High throughput physicochemical profiling for drug discovery

Biological assay challenges from compound solubility: strategies for bioassay optimization

Evidence-based approach to assess passive diffusion and carrier-mediated drug transport

Passive Lipoidal Diffusion and Carrier-Mediated Cell Uptake Are Both Important Mechanisms of Membrane Permeation in Drug Disposition

High throughput artificial membrane permeability assay for blood–brain barrier

Comparison of blood–brain barrier permeability assays: in situ brain perfusion, MDR1-MDCKII and PAMPA-BBB

Blood-brain barrier in drug discovery: optimizing brain exposure of CNS drugs and minimizing brain side effects for peripheral drugs

Development and application of high throughput plasma stability assay for drug discovery

Quantification of cyclocreatine in mouse and rat plasma using hydrophilic-interaction ultra-performance liquid chromatography-tandem mass spectrometry

Combined Application of Parallel Artificial Membrane Permeability Assay and Caco-2 Permeability Assays in Drug Discovery

Drug-like property concepts in pharmaceutical design

The Critical Role of Passive Permeability in Designing Successful Drugs

Utility of mass spectrometry for pharmaceutical profiling applications

Identification of a series of benzoxazoles as potent 5-HT6 ligands

Pharmaceutical profiling method for lipophilicity and integrity using liquid chromatography–mass spectrometry

Profiling drug-like properties in discovery research

Pharmaceutical profiling in drug discovery

Synthesis and Structure–Activity Relationship Studies of 4‑((2-Hydroxy-3-methoxybenzyl)amino)benzenesulfonamide Derivatives as Potent and Selective Inhibitors of 12-Lipoxygenase

In vitro solubility assays in drug discovery

Synthesis and Structure–Activity Relationship Studies of N‑Benzyl-2-phenylpyrimidin-4-amine Derivatives as Potent USP1/UAF1 Deubiquitinase Inhibitors with Anticancer Activity against Nonsmall Cell Lung Cancer

Hybrid triple quadrupole-linear ion trap mass spectrometry in fragmentation mechanism studies: application to structure elucidation of buspirone and one of its metabolites

Insights for Predicting Blood-Brain Barrier Penetration of CNS Targeted Molecules Using QSPR Approaches

Strategies to assess blood-brain barrier penetration

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