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Mechanism-Based Inactivation of Human Cytochromes P450s: Experimental Characterization, Reactive Intermediates, and Clinical Implications

Chemical research in toxicology, 2008-01, Vol.21 (1), p.189-205

2008

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The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivation

Drug metabolism and disposition, 2013-04, Vol.41 (4), p.858

2013

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Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases

Drug metabolism and disposition, 2004-06, Vol.32 (6), p.587

2004

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Anandamide metabolism by human liver and kidney microsomal cytochrome p450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides

The Journal of pharmacology and experimental therapeutics, 2007-05, Vol.321 (2), p.590

2007

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Role of the Highly Conserved Threonine in Cytochrome P450 2E1: Prevention of H2O2‑Induced Inactivation during Electron Transfer

Biochemistry (Easton), 2013-07, Vol.52 (27), p.4636-4647

2013

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The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5

The Journal of pharmacology and experimental therapeutics, 2005-04, Vol.313 (1), p.154

2005

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The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9

Drug metabolism and disposition, 2002-06, Vol.30 (6), p.709

2002

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Metabolism of efavirenz and 8-hydroxyefavirenz by P450 2B6 leads to inactivation by two distinct mechanisms

The Journal of pharmacology and experimental therapeutics, 2006-07, Vol.318 (1), p.345

2006

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Mechanistic analysis of the inactivation of cytochrome P450 2B6 by phencyclidine: effects on substrate binding, electron transfer, and uncoupling

Drug metabolism and disposition, 2009-04, Vol.37 (4), p.745

2009

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Differential inhibition of cytochromes P450 3A4 and 3A5 by the newly synthesized coumarin derivatives 7-coumarin propargyl ether and 7-(4-trifluoromethyl)coumarin propargyl ether

Drug metabolism and disposition, 2008-11, Vol.36 (11), p.2234

2008

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The naturally occurring cytochrome P450 (P450) 2B6 K262R mutant of P450 2B6 exhibits alterations in substrate metabolism and inactivation

Drug metabolism and disposition, 2005-06, Vol.33 (6), p.795

2005

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Metabolism of bergamottin by cytochromes P450 2B6 and 3A5

The Journal of pharmacology and experimental therapeutics, 2006-09, Vol.318 (3), p.992

2006

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The mechanism-based inactivation of human cytochrome P450 2B6 by phencyclidine

Drug metabolism and disposition, 2003-01, Vol.31 (1), p.46

2003

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Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6

The Journal of pharmacology and experimental therapeutics, 2002-06, Vol.301 (3), p.945

2002

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Novel reversible inactivation of cytochrome P450 2E1 T303A by tert-butyl acetylene: the role of threonine 303 in proton delivery to the active site of cytochrome P450 2E1

The Journal of pharmacology and experimental therapeutics, 2004-07, Vol.310 (1), p.281

2004

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Synthesis of substituted phenyl diaziridines and characterization as mechanism-based inactivators of human cytochrome P450 2B6

Drug metabolism and disposition, 2006-11, Vol.34 (11), p.1849

2006

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Structure-activity relationship and elucidation of the determinant factor(s) responsible for the mechanism-based inactivation of cytochrome P450 2B6 by substituted phenyl diaziridines

Drug metabolism and disposition, 2006-12, Vol.34 (12), p.2102

2006

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Inactivation of Cytochrome P450 2B1 by Benzyl Isothiocyanate, a Chemopreventative Agent from Cruciferous Vegetables

Chemical research in toxicology, 2000-12, Vol.13 (12), p.1349-1359

2000

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The functional role of threonine-205 in the mechanism-based inactivation of P450 2B1 by two ethynyl substrates: the importance of the F helix in catalysis

The Journal of pharmacology and experimental therapeutics, 2004-12, Vol.311 (3), p.855

2004

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Modification of Serine 360 by a Reactive Intermediate of 17-a-Ethynylestradiol Results in Mechanism-Based Inactivation of Cytochrome P450s 2B1 and 2B6

Chemical research in toxicology, 2008-10, Vol.21 (10), p.1956-1963

2008

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Mechanism-based inactivation of cytochrome P450 3A4 by 17 alpha-ethynylestradiol: evidence for heme destruction and covalent binding to protein

The Journal of pharmacology and experimental therapeutics, 2002-04, Vol.301 (1), p.160

2002

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Modification of Serine 360 by a Reactive Intermediate of 17-α-Ethynylestradiol Results in Mechanism-Based Inactivation of Cytochrome P450s 2B1 and 2B6

Chemical research in toxicology, 2008-10, Vol.21 (10), p.1956-1963

2008

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Inactivation of Cytochrome P450 2E1 by Benzyl Isothiocyanate

Chemical research in toxicology, 1999-07, Vol.12 (7), p.582-587

1999

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Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites

The Journal of pharmacology and experimental therapeutics, 2002-02, Vol.300 (2), p.549

2002

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Mutation of Tyrosine 190 to Alanine Eliminates the Inactivation of Cytochrome P450 2B1 by Peroxynitrite

Chemical research in toxicology, 2003-02, Vol.16 (2), p.129-136

2003

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Mechanism-Based Inactivation of Human Cytochromes P450s: Experimental Characterization, Reactive Intermediates, and Clinical Implications

The inactivation of human CYP2E1 by phenethyl isothiocyanate, a naturally occurring chemopreventive agent, and its oxidative bioactivation

Silybin inactivates cytochromes P450 3A4 and 2C9 and inhibits major hepatic glucuronosyltransferases

Anandamide metabolism by human liver and kidney microsomal cytochrome p450 enzymes to form hydroxyeicosatetraenoic and epoxyeicosatrienoic acid ethanolamides

Role of the Highly Conserved Threonine in Cytochrome P450 2E1: Prevention of H2O2‑Induced Inactivation during Electron Transfer

The grapefruit juice effect is not limited to cytochrome P450 (P450) 3A4: evidence for bergamottin-dependent inactivation, heme destruction, and covalent binding to protein in P450s 2B6 and 3A5

The licorice root derived isoflavan glabridin inhibits the activities of human cytochrome P450S 3A4, 2B6, and 2C9

Metabolism of efavirenz and 8-hydroxyefavirenz by P450 2B6 leads to inactivation by two distinct mechanisms

Mechanistic analysis of the inactivation of cytochrome P450 2B6 by phencyclidine: effects on substrate binding, electron transfer, and uncoupling

Differential inhibition of cytochromes P450 3A4 and 3A5 by the newly synthesized coumarin derivatives 7-coumarin propargyl ether and 7-(4-trifluoromethyl)coumarin propargyl ether

The naturally occurring cytochrome P450 (P450) 2B6 K262R mutant of P450 2B6 exhibits alterations in substrate metabolism and inactivation

Metabolism of bergamottin by cytochromes P450 2B6 and 3A5

The mechanism-based inactivation of human cytochrome P450 2B6 by phencyclidine

Effect of tamoxifen on the enzymatic activity of human cytochrome CYP2B6

Novel reversible inactivation of cytochrome P450 2E1 T303A by tert-butyl acetylene: the role of threonine 303 in proton delivery to the active site of cytochrome P450 2E1

Synthesis of substituted phenyl diaziridines and characterization as mechanism-based inactivators of human cytochrome P450 2B6

Structure-activity relationship and elucidation of the determinant factor(s) responsible for the mechanism-based inactivation of cytochrome P450 2B6 by substituted phenyl diaziridines

Inactivation of Cytochrome P450 2B1 by Benzyl Isothiocyanate, a Chemopreventative Agent from Cruciferous Vegetables

The functional role of threonine-205 in the mechanism-based inactivation of P450 2B1 by two ethynyl substrates: the importance of the F helix in catalysis

Modification of Serine 360 by a Reactive Intermediate of 17-a-Ethynylestradiol Results in Mechanism-Based Inactivation of Cytochrome P450s 2B1 and 2B6

Mechanism-based inactivation of cytochrome P450 3A4 by 17 alpha-ethynylestradiol: evidence for heme destruction and covalent binding to protein

Modification of Serine 360 by a Reactive Intermediate of 17-α-Ethynylestradiol Results in Mechanism-Based Inactivation of Cytochrome P450s 2B1 and 2B6

Inactivation of Cytochrome P450 2E1 by Benzyl Isothiocyanate

Effect of 17-alpha-ethynylestradiol on activities of cytochrome P450 2B (P450 2B) enzymes: characterization of inactivation of P450s 2B1 and 2B6 and identification of metabolites

Mutation of Tyrosine 190 to Alanine Eliminates the Inactivation of Cytochrome P450 2B1 by Peroxynitrite

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