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In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans

Drug metabolism and disposition, 2012-01, Vol.40 (1), p.130-138

2012

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Brief Report: Intestinal Dysbiosis in Ankylosing Spondylitis

Arthritis & rheumatology (Hoboken, N.J.), 2015-03, Vol.67 (3), p.686-691

2015

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Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective

Clinical pharmacology and therapeutics, 2018-11, Vol.104 (5), p.916-932

2018

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Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?

Drug metabolism and disposition, 2018-11, Vol.46 (11), p.1658-1669

2018

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The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613

Antioxidants & redox signaling, 2013-08, Vol.19 (5), p.465-481

2013

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Managing the challenge of chemically reactive metabolites in drug development

Nature reviews. Drug discovery, 2011-04, Vol.10 (4), p.292-306

2011

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In Vitro Approach to Assess the Potential for Risk of Idiosyncratic Adverse Reactions Caused by Candidate Drugs

Chemical research in toxicology, 2012-08, Vol.25 (8), p.1616-1632

2012

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Genetic analysis of ALS cases in the isolated island population of Malta

European journal of human genetics : EJHG, 2021-04, Vol.29 (4), p.604-614

2021

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Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes

Toxicology in vitro, 2014-03, Vol.28 (2), p.171-181

2014

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Best practices in DNA methylation: lessons from inflammatory bowel disease, psoriasis and ankylosing spondylitis

Arthritis research & therapy, 2019-06, Vol.21 (1), p.133-133, Article 133

2019

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Quantification of Drug-Induced Inhibition of Canalicular Cholyl-l-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging

Toxicological sciences, 2015-11, Vol.148 (1), p.48-59

2015

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Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis

PLoS genetics, 2020-08, Vol.16 (8), p.e1008906-e1008906

2020

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Human biology-based drug safety evaluation: scientific rationale, current status and future challenges

Expert opinion on drug metabolism & toxicology, 2017-05, Vol.13 (5), p.567-574

Kenna, J. Gerry

2017

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In vitro pharmacologic profiling aids systemic toxicity assessment of chemicals

Toxicology and applied pharmacology, 2024-11, Vol.492, p.117131, Article 117131

2024

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Human Blood CD1c + Dendritic Cells Promote Th1 and Th17 Effector Function in Memory CD4 + T Cells

Frontiers in immunology, 2017-08, Vol.8, p.971-971

2017

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Genotype by sex interactions in ankylosing spondylitis

Nature genetics, 2023-01, Vol.55 (1), p.14-16

2023

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Looking Beyond Th17 Cells: A Role for Tr1 Cells in Ankylosing Spondylitis?

Frontiers in immunology, 2020-12, Vol.11, p.608900-608900

2020

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A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans

Toxicological sciences, 2014-01, Vol.137 (1), p.189-211

2014

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RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis-Novel Targets for Therapy?

Frontiers in immunology, 2019-01, Vol.9, p.3132-3132

2019

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Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients

The Journal of pharmacology and experimental therapeutics, 2014-08, Vol.350 (2), p.387-402

2014

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Watershed- and reach-scale drivers of phosphorus retention and release by streambed sediment in a western Lake Erie watershed during summer

The Science of the total environment, 2023-03, Vol.863, p.160804-160804, Article 160804

2023

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Whole-exome re-sequencing in a family quartet identifies POP1 mutations as the cause of a novel skeletal dysplasia

PLoS genetics, 2011-03, Vol.7 (3), p.e1002027-e1002027

2011

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Better science for safer medicines: the human imperative

Journal of the Royal Society of Medicine, 2018-12, Vol.111 (12), p.433-438

2018

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Blockade of PD-1/PD-L1 promotes adoptive T-cell immunotherapy in a tolerogenic environment

PloS one, 2015-03, Vol.10 (3), p.e0119483-e0119483

2015

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In vitro inhibition of the bile salt export pump correlates with risk of cholestatic drug-induced liver injury in humans

Brief Report: Intestinal Dysbiosis in Ankylosing Spondylitis

Can Bile Salt Export Pump Inhibition Testing in Drug Discovery and Development Reduce Liver Injury Risk? An International Transporter Consortium Perspective

Do In Vitro Assays Predict Drug Candidate Idiosyncratic Drug-Induced Liver Injury Risk?

The gasotransmitter hydrogen sulfide induces nrf2-target genes by inactivating the keap1 ubiquitin ligase substrate adaptor through formation of a disulfide bond between cys-226 and cys-613

Managing the challenge of chemically reactive metabolites in drug development

In Vitro Approach to Assess the Potential for Risk of Idiosyncratic Adverse Reactions Caused by Candidate Drugs

Genetic analysis of ALS cases in the isolated island population of Malta

Evaluation of the use of imaging parameters for the detection of compound-induced hepatotoxicity in 384-well cultures of HepG2 cells and cryopreserved primary human hepatocytes

Best practices in DNA methylation: lessons from inflammatory bowel disease, psoriasis and ankylosing spondylitis

Quantification of Drug-Induced Inhibition of Canalicular Cholyl-l-Lysyl-Fluorescein Excretion From Hepatocytes by High Content Cell Imaging

Epistatic interactions between killer immunoglobulin-like receptors and human leukocyte antigen ligands are associated with ankylosing spondylitis

Human biology-based drug safety evaluation: scientific rationale, current status and future challenges

In vitro pharmacologic profiling aids systemic toxicity assessment of chemicals

Human Blood CD1c + Dendritic Cells Promote Th1 and Th17 Effector Function in Memory CD4 + T Cells

Genotype by sex interactions in ankylosing spondylitis

Looking Beyond Th17 Cells: A Role for Tr1 Cells in Ankylosing Spondylitis?

A correlation between the in vitro drug toxicity of drugs to cell lines that express human P450s and their propensity to cause liver injury in humans

Genome-wide association study in Turkish and Iranian populations identify rare familial Mediterranean fever gene (MEFV) polymorphisms associated with ankylosing spondylitis

RUNX3 and T-Bet in Immunopathogenesis of Ankylosing Spondylitis-Novel Targets for Therapy?

Mass spectrometric characterization of circulating covalent protein adducts derived from a drug acyl glucuronide metabolite: multiple albumin adductions in diclofenac patients

Watershed- and reach-scale drivers of phosphorus retention and release by streambed sediment in a western Lake Erie watershed during summer

Whole-exome re-sequencing in a family quartet identifies POP1 mutations as the cause of a novel skeletal dysplasia

Better science for safer medicines: the human imperative

Blockade of PD-1/PD-L1 promotes adoptive T-cell immunotherapy in a tolerogenic environment

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