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Hemoglobin-Based Oxygen Carrier (HBOC) Development in Trauma: Previous Regulatory Challenges, Lessons Learned, and a Path Forward

Oxygen Transport to Tissue XXXIX, p.343-350

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An Overview of Two Human Trials of Perfluorocarbon Emulsions in Noncardiac Surgery

Shock (Augusta, Ga.), 2019-10, Vol.52 (1S Suppl 1), p.116-118

2019

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Clinical Evaluation of MP4CO: A Phase 1b Escalating-Dose, Safety and Tolerability Study in Stable Adult Patients with Sickle Cell Disease

Advances in experimental medicine and biology, 2016, Vol.923, p.23-29

2016

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Evaluation of MP4OX for prevention of perioperative hypotension in patients undergoing primary hip arthroplasty with spinal anesthesia: a randomized, double-blind, multicenter study

Anesthesiology (Philadelphia), 2011-05, Vol.114 (5), p.1048-1063

2011

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A double-blind, randomized, multicenter study of MP4OX for treatment of perioperative hypotension in patients undergoing primary hip arthroplasty under spinal anesthesia

Anesthesia and analgesia, 2011-04, Vol.112 (4), p.759-773

2011

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Perflubron emulsion delays blood transfusions in orthopedic surgery

Anesthesiology (Philadelphia), 1999-11, Vol.91 (5), p.1195-1208

1999

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Hemoglobin-based blood substitutes and risk of myocardial infarction and death

JAMA : the journal of the American Medical Association, 2008-09, Vol.300 (11), p.1295; author reply 1298

2008

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Causes of metabolic acidosis in canine hemorrhagic shock: role of unmeasured ions

Critical care (London, England), 2007-01, Vol.11 (6), p.R130-R130, Article R130

2007

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Randomized safety studies of intravenous perflubron emulsion. II. Effects on immune function in healthy volunteers

Anesthesia and analgesia, 2000-10, Vol.91 (4), p.812-822

2000

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Randomized safety studies of intravenous perflubron emulsion. I. Effects on coagulation function in healthy volunteers

Anesthesia and analgesia, 2000-10, Vol.91 (4), p.804-811

2000

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Oxygen therapeutics ("blood substitutes") where are they, and what can we expect?

Advances in experimental medicine and biology, 2003, Vol.540, p.207

Keipert, Peter E

2003

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Effect of hemoglobin- and Perflubron-based oxygen carriers on common clinical laboratory tests

Clinical chemistry (Baltimore, Md.), 1997-09, Vol.43 (9), p.1732-1737

1997

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Perflubron emulsion (AF0144) augments harvesting of autologous blood: A phase II study in cardiac surgery

Journal of cardiothoracic and vascular anesthesia, 2002-10, Vol.16 (5), p.555-560

2002

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Safety and Tolerability Of MP4CO: A Dose Escalation Study In Stable Patients With Sickle Cell Disease

Blood, 2013-11, Vol.122 (21), p.2205-2205

2013

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Hemodilution and hyperoxia locally change distribution of regional pulmonary perfusion in dogs

American journal of physiology. Heart and circulatory physiology, 1998-02, Vol.274 (2), p.H520-H528

1998

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Evaluation of MP4OX for Prevention of Perioperative Hypotension in Patients Undergoing Primary Hip Arthroplasty with Spinal Anesthesia

Anesthesiology (Philadelphia), 2011-05, Vol.114 (5), p.1048-1063

2011

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A PROSPECTIVE EVALUATION OF THE EFFECTS OF PERFLUBRON EMULSION ON OXYGEN DYNAMICS IN PATIENTS UNDERGOING MODERATE BLOOD LOSS SURGERY

Anesthesiology (Philadelphia), 1998-09, Vol.89 (Supplement), p.396

1998

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Hemoglobin-based blood substitutes and risk of myocardial infarction and death

JAMA : the journal of the American Medical Association, 2008-09, Vol.300 (11), p.1295

2008

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Hemoglobin-Based Oxygen Carrier (HBOC) Development in Trauma: Previous Regulatory Challenges, Lessons Learned, and a Path Forward

Blood Substitutes and Oxygen Biotherapeutics, p.421-425

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Oxygent™, a Perfluorochemical-Based Oxygen Therapeutic for Surgical Patients

Blood Substitutes and Oxygen Biotherapeutics, p.325-334

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A Double-Blind, Randomized, Multicenter Study of MP40X for Treatment of Perioperative Hypotension in Patients Undergoing Primary Hip Arthroplasty Under Spinal Anesthesia

Anesthesia and analgesia, 2011, Vol.112 (4), p.759-773

2011

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Oxygent as a top load to colloid and hyperoxia is more effective in resuscitation from hemorrhagic shock than colloid and hyperoxia alone

Shock (Augusta, Ga.), 2005-09, Vol.24 (3), p.245-254

2005

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A Pilot Study of the Effects of a Perflubron Emulsion, AF 0104, on Mixed Venous Oxygen Tension in Anesthetized Surgical Patients

Anesthesia and analgesia, 1996-01, Vol.82 (1), p.103-107

1996

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The safety profile of Hemospan®: a new oxygen therapeutic designed using maleimide poly(ethylene) glycol conjugation to human hemoglobin

Transfusion alternatives in tranfusion medicine, 2007-12, Vol.9 (4), p.213-225

2007

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Clinical Evaluation of MP4CO: A Phase 1b Escalating-Dose, Safety and Tolerability Study in Stable Adult Patients with Sickle Cell Disease

Blood Substitutes and Oxygen Biotherapeutics, p.319-323

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Hemoglobin-Based Oxygen Carrier (HBOC) Development in Trauma: Previous Regulatory Challenges, Lessons Learned, and a Path Forward

An Overview of Two Human Trials of Perfluorocarbon Emulsions in Noncardiac Surgery

Clinical Evaluation of MP4CO: A Phase 1b Escalating-Dose, Safety and Tolerability Study in Stable Adult Patients with Sickle Cell Disease

Evaluation of MP4OX for prevention of perioperative hypotension in patients undergoing primary hip arthroplasty with spinal anesthesia: a randomized, double-blind, multicenter study

A double-blind, randomized, multicenter study of MP4OX for treatment of perioperative hypotension in patients undergoing primary hip arthroplasty under spinal anesthesia

Perflubron emulsion delays blood transfusions in orthopedic surgery

Hemoglobin-based blood substitutes and risk of myocardial infarction and death

Causes of metabolic acidosis in canine hemorrhagic shock: role of unmeasured ions

Randomized safety studies of intravenous perflubron emulsion. II. Effects on immune function in healthy volunteers

Randomized safety studies of intravenous perflubron emulsion. I. Effects on coagulation function in healthy volunteers

Oxygen therapeutics ("blood substitutes") where are they, and what can we expect?

Effect of hemoglobin- and Perflubron-based oxygen carriers on common clinical laboratory tests

Perflubron emulsion (AF0144) augments harvesting of autologous blood: A phase II study in cardiac surgery

Safety and Tolerability Of MP4CO: A Dose Escalation Study In Stable Patients With Sickle Cell Disease

Hemodilution and hyperoxia locally change distribution of regional pulmonary perfusion in dogs

Evaluation of MP4OX for Prevention of Perioperative Hypotension in Patients Undergoing Primary Hip Arthroplasty with Spinal Anesthesia

A PROSPECTIVE EVALUATION OF THE EFFECTS OF PERFLUBRON EMULSION ON OXYGEN DYNAMICS IN PATIENTS UNDERGOING MODERATE BLOOD LOSS SURGERY

Hemoglobin-based blood substitutes and risk of myocardial infarction and death

Hemoglobin-Based Oxygen Carrier (HBOC) Development in Trauma: Previous Regulatory Challenges, Lessons Learned, and a Path Forward

Oxygent™, a Perfluorochemical-Based Oxygen Therapeutic for Surgical Patients

A Double-Blind, Randomized, Multicenter Study of MP40X for Treatment of Perioperative Hypotension in Patients Undergoing Primary Hip Arthroplasty Under Spinal Anesthesia

Oxygent as a top load to colloid and hyperoxia is more effective in resuscitation from hemorrhagic shock than colloid and hyperoxia alone

A Pilot Study of the Effects of a Perflubron Emulsion, AF 0104, on Mixed Venous Oxygen Tension in Anesthetized Surgical Patients

The safety profile of Hemospan®: a new oxygen therapeutic designed using maleimide poly(ethylene) glycol conjugation to human hemoglobin

Clinical Evaluation of MP4CO: A Phase 1b Escalating-Dose, Safety and Tolerability Study in Stable Adult Patients with Sickle Cell Disease

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